Abstract:
:Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and non-motor symptoms in early PD remains to be elucidated. 171 consecutive early PD patients were recruited from tertiary clinics and genotyped for Rep1. Multivariable regression analyses were performed to examine associations between Rep1 alleles and non-motor outcome scores. Longer Rep1 alleles significantly associated with higher total Non-Motor Symptom Scale (NMSS) scores (p=.006) and Hospital Anxiety and Depression Scale (HADS) depression subscale scores (p=.002), after adjusting for covariates and Bonferroni correction. We demonstrated that SNCA Rep1 allele length influences overall non-motor symptom burden and depression in early PD patients. Further functional studies to evaluate the role of Rep1 in non-dopaminergic systems may unravel new therapeutic targets for non-motor symptoms in PD.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Yong AC,Tan YJ,Zhao Y,Lu Z,Ng EY,Ng SY,Chia NS,Choi X,Heng D,Neo S,Xu Z,Tay KY,Au WL,Tan EK,Tan LC,Ng ASdoi
10.18632/aging.104111subject
Has Abstractpub_date
2020-10-20 00:00:00pages
20880-20887issue
20issn
1945-4589pii
104111journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101878
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102397
更新日期:2019-10-31 00:00:00
abstract::Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. Caspase recruitment domain family member 6 (CARD6) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102561
更新日期:2019-12-16 00:00:00
abstract::Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102529
更新日期:2019-12-20 00:00:00
abstract::Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102678
更新日期:2020-01-09 00:00:00
abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100523
更新日期:2012-12-01 00:00:00
abstract::To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103569
更新日期:2020-07-25 00:00:00
abstract::Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103393
更新日期:2020-07-02 00:00:00
abstract::Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically age...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100999
更新日期:2016-07-01 00:00:00
abstract::Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103137
更新日期:2020-05-11 00:00:00
abstract::Mounting studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development and occurrence of several human diseases. However, the role of LINC00461 in osteoarthritis (OA) remains obscure. A CCK-8 assay was performed to detect cell viability, and qRT-PCR analysis was used to measure mRNA exp...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102839
更新日期:2020-03-10 00:00:00
abstract::Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103005
更新日期:2020-05-21 00:00:00
abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102539
更新日期:2019-12-19 00:00:00
abstract::Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202174
更新日期:2020-11-25 00:00:00
abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102110
更新日期:2019-07-22 00:00:00
abstract::Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese po...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102725
更新日期:2020-02-29 00:00:00
abstract::Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103972
更新日期:2020-11-10 00:00:00
abstract::PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100029
更新日期:2009-03-03 00:00:00
abstract::Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101867
更新日期:2019-03-26 00:00:00
abstract::DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100281
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202388
更新日期:2021-01-20 00:00:00
abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101711
更新日期:2018-12-30 00:00:00
abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102035
更新日期:2019-06-19 00:00:00
abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103649
更新日期:2020-09-14 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102581
更新日期:2019-12-18 00:00:00
abstract::There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102151
更新日期:2019-08-26 00:00:00
abstract:BACKGROUND:As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because pat...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103167
更新日期:2020-04-30 00:00:00
abstract::Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.102475
更新日期:2019-11-25 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103773
更新日期:2020-09-04 00:00:00