Abstract:
:Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenesis. In this study, we found that the expression of miR-345-5p decreased during adipogenic differentiation, and overexpression of miR-345-5p reduced lipid accumulation in adipocytes and the expression of adipocyte related genes essential to lipogenic transcription, fatty acid synthesis and fatty acid transport. In addition, miR-345-5p directly targeted the 3'UTR of vascular endothelial growth factor B, and miR-345-5p mimic inhibited the expression of vascular endothelial growth factor B at both mRNA and protein levels. In conclusion, our results demonstrate that miR-345-5p inhibits adipocyte differentiation via targeting vascular endothelial growth factor B.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Liu X,He Y,Feng Z,Sheng J,Dong A,Zhang M,Cao Ldoi
10.18632/aging.103649subject
Has Abstractpub_date
2020-09-14 00:00:00pages
17114-17121issue
17issn
1945-4589pii
103649journal_volume
12pub_type
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