Long-term environmental enrichment affects microglial morphology in middle age mice.

abstract：:Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided i...

journal_title：Aging

authors： Long XR,Zhang YJ,Zhang MY,Chen K,Zheng XFS,Wang HY

更新日期：2017-06-27 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...

journal_title：Aging

authors： Wang R,Yin C,Li XX,Yang XZ,Yang Y,Zhang MY,Wang HY,Zheng XF

更新日期：2016-06-01 00:00:00

abstract：:Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...

journal_title：Aging

authors： Cui Y,Song Y,Yan S,Cao M,Huang J,Jia D,Liu Y,Zhang S,Fan W,Cai L,Li C,Xing Y

更新日期：2020-10-25 00:00:00

abstract：:Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty...

journal_title：Aging

authors： Chen C,Park J,Wu C,Xue Q,Agogo G,Han L,Hoogendijk EO,Liu Z,Wu Z

更新日期：2020-11-18 00:00:00

abstract：:The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...

journal_title：Aging

authors： Yang L,Fu Q,Miao L,Ding Q,Li X,Wang J,Jiang G,Wang Y

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...

journal_title：Aging

authors： Chen D,Feng X,Lv Z,Xu X,Lu Y,Wu W,Wu H,Liu H,Cao L,Ye S,Chen J,Wu J

更新日期：2019-10-25 00:00:00

abstract：:The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...

journal_title：Aging

authors： Liu J,Yao R,Lu S,Xu R,Zhang H,Wei J,Zhao C,Tang Y,Li C,Liu H,Zhao X,Wei Q,Ma B

更新日期：2020-10-28 00:00:00

abstract：:In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poorer prognosis in CRC ...

journal_title：Aging

authors： Chen C,Wei M,Wang C,Sun D,Liu P,Zhong X,Yu W

更新日期：2020-06-21 00:00:00

abstract：:The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

journal_title：Aging

authors： Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

更新日期：2017-10-20 00:00:00

abstract：:Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member of the RAS protein family, was chosen as a potential regulator of OA chondrocyt...

journal_title：Aging

authors： Lü G,Li L,Wang B,Kuang L

更新日期：2020-02-12 00:00:00

abstract：:Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity against both drug-...

journal_title：Aging

authors： Fiorillo M,Lamb R,Tanowitz HB,Cappello AR,Martinez-Outschoorn UE,Sotgia F,Lisanti MP

更新日期：2016-08-01 00:00:00

abstract：:In humans, the ERBB2 gene amplification and overexpression are biomarkers for invasive breast cancer and a therapeutic target. Also, TOP2α gene aberrations predict the response to anthracycline-based adjuvant chemotherapy. Although feline mammary tumors (FMTs) are good models in comparative oncology, scarce data is av...

journal_title：Aging

authors： Ferreira D,Soares M,Correia J,Adega F,Ferreira F,Chaves R

更新日期：2019-07-12 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...

journal_title：Aging

authors： Zhang G,Xu Y,Zou C,Tang Y,Lu J,Gong Z,Ma G,Zhang W,Jiang P

更新日期：2019-10-30 00:00:00

abstract：BACKGROUND:Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Long noncoding RNA ANRIL (lncRNA-ANRIL) is critical in vascular homeostasis. Metformin produces multiple beneficial effects in atherosclerosis. However, the underlying mechanisms need to be elucidated. METHODS ...

journal_title：Aging

authors： Hu DJ,Li ZY,Zhu YT,Li CC

更新日期：2020-12-19 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...

journal_title：Aging

authors： Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

更新日期：2020-07-02 00:00:00

abstract：:To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was rel...

journal_title：Aging

authors： Song Y,Jin D,Chen J,Luo Z,Chen G,Yang Y,Liu X

更新日期：2020-06-24 00:00:00

abstract：:The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

journal_title：Aging

authors： Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

更新日期：2020-01-21 00:00:00

abstract：:Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...

journal_title：Aging

authors： Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

更新日期：2016-07-01 00:00:00

abstract：:In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...

journal_title：Aging

authors： Jiang X,Chen D

更新日期：2020-10-20 00:00:00

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...

journal_title：Aging

authors： Villota C,Varas-Godoy M,Jeldes E,Campos A,Villegas J,Borgna V,Burzio LO,Burzio VA

更新日期：2018-12-30 00:00:00

abstract：:Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...

journal_title：Aging

authors： Wang J,Wei H,Huang Y,Chen D,Zeng G,Lian Y,Huang Y

更新日期：2019-08-13 00:00:00

abstract：:Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donors >60 years of age, we found tha...

journal_title：Aging

authors： Müller-Durovic B,Grählert J,Devine OP,Akbar AN,Hess C

更新日期：2019-01-27 00:00:00

abstract：:Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

journal_title：Aging

authors： Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

更新日期：2018-10-25 00:00:00

abstract：:Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

journal_title：Aging

authors： Ren W,Guan W,Zhang J,Wang F,Xu G

更新日期：2019-04-14 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...

journal_title：Aging

authors： Yang H,Jiang Y,Zhang Y,Xu Y,Zhang C,Han J,Su F,Liu X,Mi K,Liu B,Shang D

更新日期：2019-12-18 00:00:00

abstract：:The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin a...

journal_title：Aging

authors： Qi Z,Ji H,Le M,Li H,Wieland A,Bauer S,Liu L,Wink M,Herr I

更新日期：2021-01-20 00:00:00

abstract：:The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

journal_title：Aging

authors： Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

更新日期：2020-11-20 00:00:00

abstract：:We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at ad...

journal_title：Aging

authors： Zhang C,Xu G,Xu Y,Wu H,Guo X,Mao M,Baklaushev VP,Chekhonin VP,Peltzer K,Bai Y,Wang G,Ma W,Wang X

更新日期：2020-08-27 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00