Cognitive frailty in relation to adverse health outcomes independent of multimorbidity: results from the China health and retirement longitudinal study.

abstract：:To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...

journal_title：Aging

authors： Xu F,Zhang Q,Wang H

更新日期：2020-07-25 00:00:00

abstract：:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

journal_title：Aging

authors： Guo B,Zhang Q,Wang H,Chang P,Tao K

更新日期：2018-04-17 00:00:00

abstract：:Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...

journal_title：Aging

authors： Zhou Z,Wu L,Liu Z,Zhang X,Han S,Zhao N,Bao H,Yuan W,Chen J,Ji J,Shu X

更新日期：2020-05-15 00:00:00

abstract：:The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...

journal_title：Aging

authors： Zucchelli A,Marengoni A,Rizzuto D,Calderón-Larrañaga A,Zucchelli M,Bernabei R,Onder G,Fratiglioni L,Vetrano DL

更新日期：2020-04-28 00:00:00

abstract：:Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...

journal_title：Aging

authors： Liu Y,Ma L,Shangguan F,Zhao X,Wang W,Gao Z,Zhou H,Qu G,Huang Y,An J,Xue J,Yang S,Cao Q

更新日期：2020-09-05 00:00:00

abstract：:Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

journal_title：Aging

authors： Guest I,Ilic Z,Scrable H,Sell S

更新日期：2015-12-01 00:00:00

abstract：:Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...

journal_title：Aging

authors： Huang H,Liu R,Huang Y,Feng Y,Fu Y,Chen L,Chen Z,Cai Y,Zhang Y,Chen Y

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...

journal_title：Aging

authors： Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...

journal_title：Aging

authors： Chen D,Feng X,Lv Z,Xu X,Lu Y,Wu W,Wu H,Liu H,Cao L,Ye S,Chen J,Wu J

更新日期：2019-10-25 00:00:00

abstract：:Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in B...

journal_title：Aging

authors： Wang L,Li H,Qiao Q,Ge Y,Ma L,Wang Q

更新日期：2020-11-07 00:00:00

abstract：:Numerous studies have investigated the differences in the mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state functional magnetic resonance imaging. However, whether the mean FC is increased, decreased or unchanged in aMCI patien...

journal_title：Aging

authors： Liang J,Li Y,Liu H,Zhang S,Wang M,Chu Y,Ye J,Xi Q,Zhao X

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...

journal_title：Aging

authors： Chen K,Li L,Qu S,Pan X,Sun Y,Wan F,Yu B,Zhou L,Zhu X

更新日期：2020-11-24 00:00:00

abstract：:Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have made some progress reporting reduced respiration, dynamic structural m...

journal_title：Aging

authors： Ingram T,Chakrabarti L

更新日期：2016-12-13 00:00:00

abstract：:Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...

journal_title：Aging

authors： Kwon HK,Kim JM,Shin SC,Sung ES,Kim HS,Park GC,Cheon YI,Lee JC,Lee BJ

更新日期：2020-11-05 00:00:00

abstract：:Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...

journal_title：Aging

authors： Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

更新日期：2016-07-01 00:00:00

abstract：:Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

journal_title：Aging

authors： Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

更新日期：2019-10-06 00:00:00

abstract：:Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...

journal_title：Aging

authors： Fujie S,Hasegawa N,Sanada K,Hamaoka T,Maeda S,Padilla J,Martinez-Lemus LA,Iemitsu M

更新日期：2020-01-09 00:00:00

abstract：OBJECTIVE:To explore the correlations among alternative splicing (AS), splicing factors (SF) and survival outcome in adrenocortical carcinoma (ACC) patients. RESULTS:A total of 92 ACC patients were included. Univariate analysis identified 3919 AS events significantly associated with overall survival. Lasso method foll...

journal_title：Aging

authors： Xu N,Ke ZB,Lin XD,Lin F,Chen SH,Wu YP,Chen YH,Wei Y,Zheng QS

更新日期：2020-03-26 00:00:00

abstract：:Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers ...

journal_title：Aging

authors： Peto MV,De la Guardia C,Winslow K,Ho A,Fortney K,Morgen E

更新日期：2017-08-31 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00

abstract：:Epigenetic regulation of various genomic functions, including gene expression, provide mechanisms whereby an organism can dynamically respond to changes in its environment and modify gene expression accordingly. One epigenetic mechanism implicated in human aging and age-related disorders is DNA methylation. Isolated p...

journal_title：Aging

authors： Benton MC,Sutherland HG,Macartney-Coxson D,Haupt LM,Lea RA,Griffiths LR

更新日期：2017-02-28 00:00:00

abstract：:Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...

journal_title：Aging

authors： Fan R,Olbricht G,Baker X,Hou C

更新日期：2016-12-08 00:00:00

abstract：:The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

journal_title：Aging

authors： Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

更新日期：2019-07-22 00:00:00

abstract：:A poor outcome for pancreatic ductal adenocarcinoma (PDAC) patients is still a challenge worldwide. The aim of our study is to investigate the potential of key laminin subunits for being used both as a diagnostic and prognostic biomarker for PDAC patients. We evaluated the mRNA expression and prognostic value of lamin...

journal_title：Aging

authors： Yang C,Liu Z,Zeng X,Wu Q,Liao X,Wang X,Han C,Yu T,Zhu G,Qin W,Peng T

更新日期：2019-06-10 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：:TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

journal_title：Aging

authors： Zhang T,Zhao Y,Zhao Y,Zhou J

更新日期：2020-03-25 00:00:00

abstract：:Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...

journal_title：Aging

authors： Wang C,Zhang X,Ling Q,Zheng S,Xu X

更新日期：2020-12-03 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...

journal_title：Aging

authors： Wang R,Yin C,Li XX,Yang XZ,Yang Y,Zhang MY,Wang HY,Zheng XF

更新日期：2016-06-01 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00