Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression.

Abstract:

:Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in BC tissues and cell lines. The overexpressed circSEMA5A was correlated with malignant characteristics of BC. In vitro data indicated that circSEMA5A promoted proliferation, suppressed apoptosis, facilitated migration, accelerated invasion, enhanced angiogenesis and promotes glycolysis of BC. Mechanistically, circSEMA5A served as a miRNA sponge for miR-330-5p to upregulates Enolase 1 (ENO1) expression and facilitated the activation of Akt and β-catenin signaling pathways. Then, we showed that circSEMA5A exerted its biological functions partially via miR-330-5p/ENO1 signaling. Moreover, circSEMA5A raised SEMA5A expression by recruiting EIF4A3 to enhance the mRNA stability of SEMA5A, and thereby accelerated BC angiogenesis. To sum up, circSEMA5A is upregulated in BC and facilitates BC progression by mediating miR-330-5p/ENO1 signaling and upregulating SEMA5A expression.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Wang L,Li H,Qiao Q,Ge Y,Ma L,Wang Q

doi

10.18632/aging.103971

subject

Has Abstract

pub_date

2020-11-07 00:00:00

pages

21674-21686

issue

21

issn

1945-4589

pii

103971

journal_volume

12

pub_type

杂志文章

相关文献

Aging-US文献大全
  • Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring.

    abstract:UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100484

    authors: Vitale G,Brugts MP,Ogliari G,Castaldi D,Fatti LM,Varewijck AJ,Lamberts SW,Monti D,Bucci L,Cevenini E,Cavagnini F,Franceschi C,Hofland LJ,Mari D,Janssen J

    更新日期:2012-09-01 00:00:00

  • Aging induces a step-like change in the motor ability structure of athletes.

    abstract::Many studies have investigated how aging decreases human strength and endurance. However, understanding the effect of aging on human motor ability requires more than knowledge of the separate temporal profile of individual motor function because the structure of human motor ability is multi-dimensional. We address the...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102126

    authors: Panday SB,Pathak P,Moon J,Ahn J

    更新日期:2019-07-30 00:00:00

  • Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.

    abstract::Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202453

    authors: Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

    更新日期:2020-12-29 00:00:00

  • COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway.

    abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102300

    authors: Long R,Liu Z,Li J,Yu H

    更新日期:2019-10-17 00:00:00

  • Pan-metastatic cancer analysis of prognostic factors and a prognosis-based metastatic cancer classification system.

    abstract::We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at ad...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103467

    authors: Zhang C,Xu G,Xu Y,Wu H,Guo X,Mao M,Baklaushev VP,Chekhonin VP,Peltzer K,Bai Y,Wang G,Ma W,Wang X

    更新日期:2020-08-27 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103566

    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00

  • Knockdown of CENPF inhibits the progression of lung adenocarcinoma mediated by ERβ2/5 pathway.

    abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202303

    authors: Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

    更新日期:2021-01-10 00:00:00

  • The role of commensal microbes in the lifespan of Drosophila melanogaster.

    abstract::Commensal microbes have mutualistic relationships with their host and mainly live in the host intestine. There are many studies on the relationships between commensal microbes and host physiology. However, there are inconsistent results on the effects of commensal microbes on host lifespan. To clarify this controversy...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102073

    authors: Lee HY,Lee SH,Lee JH,Lee WJ,Min KJ

    更新日期:2019-07-12 00:00:00

  • System level characterization of small molecule drugs and their affected long noncoding RNAs.

    abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102581

    authors: Yang H,Jiang Y,Zhang Y,Xu Y,Zhang C,Han J,Su F,Liu X,Mi K,Liu B,Shang D

    更新日期:2019-12-18 00:00:00

  • Predicting chromosome 1p/19q codeletion by RNA expression profile: a comparison of current prediction models.

    abstract:BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101795

    authors: Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

    更新日期:2019-02-02 00:00:00

  • MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat.

    abstract::Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103692

    authors: Chen Y,Li J,Ma B,Li N,Wang S,Sun Z,Xue C,Han Q,Wei J,Zhao RC

    更新日期:2020-09-23 00:00:00

  • Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

    abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103459

    authors: Honkonen M,Vääräniemi K,Saijonmaa O,Nyman A,Tikkakoski AJ,Koskela J,Lehtimäki T,Kähönen M,Mustonen J,Fyhrquist F,Pörsti I

    更新日期:2020-06-23 00:00:00

  • Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation.

    abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102324

    authors: Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

    更新日期:2019-10-06 00:00:00

  • MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

    abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101948

    authors: Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

    更新日期:2019-05-07 00:00:00

  • Can Serum Cystatin C predict long-term survival in cardiac surgery patients?

    abstract::Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101403

    authors: Rovella V,Marrone G,Dessì M,Ferrannini M,Toschi N,Pellegrino A,Casasco M,Di Daniele N,Noce A

    更新日期:2018-03-27 00:00:00

  • Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions.

    abstract::Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103348

    authors: Deng Z,Zhou L,Wang Y,Liao S,Huang Y,Shan Y,Tan S,Zeng Q,Peng L,Huang H,Lu Z

    更新日期:2020-06-22 00:00:00

  • Quantitative acetylome and phosphorylome analysis reveals Girdin affects pancreatic cancer progression through regulating Cortactin.

    abstract::The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103032

    authors: Yang L,Fu Q,Miao L,Ding Q,Li X,Wang J,Jiang G,Wang Y

    更新日期:2020-05-05 00:00:00

  • Age-associated epigenetic modifications in human DNA increase its immunogenicity.

    abstract::Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks of aging. However, the underlying mechanisms are not well understood. Age-associated alterations in the DNA either due to oxidative damage, defects in DNA repair or epigenetic modifications such as methylation that lead ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100121

    authors: Agrawal A,Tay J,Yang GE,Agrawal S,Gupta S

    更新日期:2010-03-20 00:00:00

  • Identification of a hippocampal lncRNA-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion.

    abstract::Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103901

    authors: Yao ZH,Wang J,Shen BZ,Li YT,Yao XL,Zhang SF,Zhang Y,Hu JC,Xie YC

    更新日期:2020-10-11 00:00:00

  • Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.

    abstract::Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103537

    authors: Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

    更新日期:2020-08-29 00:00:00

  • Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.

    abstract::Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102765

    authors: Bo H,Liu Z,Tang R,Gong G,Wang X,Zhang H,Zhu F,Zhou D,Zhu W,Tan Y,Fan L

    更新日期:2020-02-06 00:00:00

  • Increased intrinsic default-mode network activity as a compensatory mechanism in aMCI: a resting-state functional connectivity MRI study.

    abstract::Numerous studies have investigated the differences in the mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state functional magnetic resonance imaging. However, whether the mean FC is increased, decreased or unchanged in aMCI patien...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102986

    authors: Liang J,Li Y,Liu H,Zhang S,Wang M,Chu Y,Ye J,Xi Q,Zhao X

    更新日期:2020-04-01 00:00:00

  • The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells.

    abstract::Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP). There are contrasting studies on the role of the SASP in cancer. Studies suggested that cancer cells may misuse the senescent secretome for their growth. Other investig...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102172

    authors: Alessio N,Aprile D,Squillaro T,Di Bernardo G,Finicelli M,Melone MA,Peluso G,Galderisi U

    更新日期:2019-08-14 00:00:00

  • Effects of enriched branched-chain amino acid supplementation on sarcopenia.

    abstract::To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103576

    authors: Ko CH,Wu SJ,Wang ST,Chang YF,Chang CS,Kuan TS,Chuang HY,Chang CM,Chou W,Wu CH

    更新日期:2020-07-26 00:00:00

  • Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.

    abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction remain largely unknown. Here, we show that mitochondrial fragmentation contributes to PASMC dysfunction through enhancement of endoplasmic reticulum...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103892

    authors: Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

    更新日期:2020-11-18 00:00:00

  • Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes.

    abstract::Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101117

    authors: Reifsnyder PC,Flurkey K,Te A,Harrison DE

    更新日期:2016-11-30 00:00:00

  • Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates.

    abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101148

    authors: Djelti F,Dhenain M,Terrien J,Picq JL,Hardy I,Champeval D,Perret M,Schenker E,Epelbaum J,Aujard F

    更新日期:2016-12-28 00:00:00

  • Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.

    abstract::Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202305

    authors: Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T

    更新日期:2020-12-19 00:00:00

  • Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

    abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103465

    authors: Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

    更新日期:2020-08-05 00:00:00

  • Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes.

    abstract::Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown longevity, anti-aging and metabolic health effects. We previously reported that the LPD has a renoprotective effect against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. However, it is uncle...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102902

    authors: Kitada M,Ogura Y,Monno I,Xu J,Koya D

    更新日期:2020-03-06 00:00:00