Abstract:
:The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest.
journal_name
Aging (Albany NY)journal_title
Agingauthors
McCubrey JA,Demidenko ZNdoi
10.18632/aging.100529subject
Has Abstractpub_date
2012-12-01 00:00:00pages
887-93issue
12issn
1945-4589pii
100529journal_volume
4pub_type
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