Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan.

abstract：:SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice and human patients. However, the role of SIRT6 in regulating vascular endothelia...

journal_title：Aging

authors： Xu S,Yin M,Koroleva M,Mastrangelo MA,Zhang W,Bai P,Little PJ,Jin ZG

更新日期：2016-05-01 00:00:00

abstract：:Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice on high-fat diet. In eighteen-month old mice randomly assigned to control, high-fat (HF), or high-fat+20% RS2 (HFRS) diet for 16 weeks, RS2 r...

journal_title：Aging

authors： Zhang Y,Chen L,Hu M,Kim JJ,Lin R,Xu J,Fan L,Qi Y,Wang L,Liu W,Deng Y,Si J,Chen S

更新日期：2020-05-25 00:00:00

abstract：:lncRNA can interact with miRNA as a ceRNA to participate in the regulation of target gene expression, thus playing an important role in the development of malignant tumors. In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. Additionally, OGFRP1 is signific...

journal_title：Aging

authors： Yan K,Hou L,Liu T,Jiao W,Ma Q,Fang Z,Zhang S,Song D,Liu J,Gao X,Fan Y

更新日期：2020-05-19 00:00:00

abstract：:Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular en...

journal_title：Aging

authors： McRobb LS,McKay MJ,Gamble JR,Grace M,Moutrie V,Santos ED,Lee VS,Zhao Z,Molloy MP,Stoodley MA

更新日期：2017-04-01 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...

journal_title：Aging

authors： Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U

更新日期：2014-06-01 00:00:00

abstract：:Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

journal_title：Aging

authors： Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

更新日期：2020-12-29 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：:Advanced age and apolipoprotein E (APOE) ε4 allele are both associated with increased risk of the Alzheimer's disease (AD). However, the extent of the joint contribution of APOE ε4 allele and age on the brain white matter integrity, cognition and their relationship are unclear. We assessed the age-related variation di...

journal_title：Aging

authors： Sun J,Zhu Z,Chen K,Wei D,Li X,Li H,Zhang J,Chen X,Chen Y,Zhang Z

更新日期：2020-06-22 00:00:00

abstract：:Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...

journal_title：Aging

authors： Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

更新日期：2012-05-01 00:00:00

abstract：:The loss of regenerative capacity of tissues is one of the major characteristics of aging. Liver represents a powerful system for investigations of mechanisms by which aging reduces regenerative capacity of tissues. The studies within last five years revealed critical role of epigenetic silencing in the inhibition of ...

journal_title：Aging

authors： Jin J,Wang GL,Timchenko L,Timchenko NA

更新日期：2009-06-22 00:00:00

abstract：:Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytoki...

journal_title：Aging

authors： Martín-Núñez E,Donate-Correa J,Ferri C,López-Castillo Á,Delgado-Molinos A,Hernández-Carballo C,Pérez-Delgado N,Rodríguez-Ramos S,Cerro-López P,Tagua VG,Mora-Fernández C,Navarro-González JF

更新日期：2020-01-27 00:00:00

abstract：:In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported th...

journal_title：Aging

authors： Halicka HD,Zhao H,Li J,Traganos F,Studzinski GP,Darzynkiewicz Z

更新日期：2012-04-01 00:00:00

abstract：:Patients with end-stage renal disease (ESRD) display phenotypic features of premature biological aging, characterized by disproportionately high morbidity and mortality at a younger age. Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is...

journal_title：Aging

authors： Sumida K,Han Z,Dashputre AA,Potukuchi PK,Kovesdy CP

更新日期：2020-07-13 00:00:00

abstract：:Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...

journal_title：Aging

authors： Jang IY,Park JH,Kim JH,Lee S,Lee E,Lee JY,Park SJ,Kim DA,Hamrick MW,Kim BJ

更新日期：2020-11-13 00:00:00

abstract：:In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19). We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020 and February 2020. Ninety-two patients were treat...

journal_title：Aging

authors： Zheng KL,Xu Y,Guo YF,Diao L,Kong XY,Wan XJ,Zhao F,Ning FZ,Wang LB,Qiao F,Zhao JM,Zhou JH,Zhong YQ,Wu SX,Chen Y,Jin G,Dong YC

更新日期：2020-10-08 00:00:00

abstract：:One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...

journal_title：Aging

authors： Niu J,Wang Y,Wang J,Bin L,Hu X

更新日期：2016-12-28 00:00:00

abstract：:Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...

journal_title：Aging

authors： Wu Y,Pei Y,Yang Z,Li K,Lou X,Cui W

更新日期：2020-10-29 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...

journal_title：Aging

authors： Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

更新日期：2020-02-19 00:00:00

abstract：:Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...

journal_title：Aging

authors： Zheng Z,Li X,You H,Zheng X,Ruan X

更新日期：2020-05-21 00:00:00

abstract：BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...

journal_title：Aging

authors： Chen D,Feng X,Lv Z,Xu X,Lu Y,Wu W,Wu H,Liu H,Cao L,Ye S,Chen J,Wu J

更新日期：2019-10-25 00:00:00

abstract：:Increase in life span in RasGrf1-deficient mice revealed that RasGrf1 deficiency promotes longevity. Interestingly, RasGrf1 is one of parentally imprinted genes transcribed from paternally-derived chromosome. Erasure of its imprinting results in RasGrf1 downregulation and has been demonstrated in a population of pluri...

journal_title：Aging

authors： Ratajczak MZ,Kucia M,Liu R,Shin DM,Bryndza E,Masternak MM,Tarnowski M,Ratajczak J,Bartke A

更新日期：2011-07-01 00:00:00

abstract：:Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...

journal_title：Aging

authors： Han B,Zhang H,Zhu Y,Han X,Wang Z,Gao Z,Yuan Y,Tian R,Zhang F,Niu R

更新日期：2020-07-10 00:00:00

abstract：BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...

journal_title：Aging

authors： Wenjing L,Yuanzheng F,Li JY,Tang LV,Yu H

更新日期：2020-12-15 00:00:00

abstract：:Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...

journal_title：Aging

authors： Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...

journal_title：Aging

authors： Zhou J,Lei J,Wang J,Lian CL,Hua L,Yang LC,Wu SG

更新日期：2020-04-22 00:00:00

abstract：:We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...

journal_title：Aging

authors： Chen J,Li M,Zhu X,Chen L,Yang S,Zhang C,Wu T,Feng X,Wang Y,Chen Q

更新日期：2020-02-07 00:00:00

abstract：:The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...

journal_title：Aging

authors： Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

更新日期：2018-12-08 00:00:00

abstract：:Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...

journal_title：Aging

authors： Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

更新日期：2020-06-02 00:00:00