Abstract:
:Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, Western blot, RT-PCR, as well as oncogenic function assay were performed. We found that the cell proliferation, colony formation, invasion and migration were decreased after LINC00857 knockdown in EAC cell lines. We also found that knockdown LINC00857 could induce apoptosis. Mechanistically, we found that the MET, STAT3, c-Myc and p-CREB proteins were decreased after LINC00857 knockdown. Our study suggests that LINC00857 may play an important oncogenic role in EAC via STAT3 and MET signaling.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Su W,Wang L,Niu F,Zou L,Guo C,Wang Z,Yang X,Wu J,Lu Y,Zhang J,Beer DG,Yang Z,Chen Gdoi
10.18632/aging.101953subject
Has Abstractpub_date
2019-05-13 00:00:00pages
2812-2821issue
9issn
1945-4589pii
101953journal_volume
11pub_type
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