One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...

journal_title：Aging

authors： Xu F,Zhang Q,Wang H

更新日期：2020-07-25 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:The inhibition of mTOR (mechanistic target of rapamycin) by the macrolide rapamycin has many beneficial effects in mice, including extension of lifespan and reduction or prevention of several age-related diseases. At the same time, chronic rapamycin treatment causes impairments in glucose metabolism including hypergly...

journal_title：Aging

authors： Liu Y,Diaz V,Fernandez E,Strong R,Ye L,Baur JA,Lamming DW,Richardson A,Salmon AB

更新日期：2014-09-01 00:00:00

abstract：:Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. In this study, taking advantage o...

journal_title：Aging

authors： Qian L,Zhang H,Gu Y,Li D,He S,Wang H,Cheng Y,Yang W,Yu H,Zhao X,Cai W,Meng L,Jin M,Wang Y,Zhang Y

更新日期：2018-12-04 00:00:00

abstract：AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...

journal_title：Aging

authors： Siu CW,Lee YK,Ho JC,Lai WH,Chan YC,Ng KM,Wong LY,Au KW,Lau YM,Zhang J,Lay KW,Colman A,Tse HF

更新日期：2012-11-01 00:00:00

abstract：:The ventral hypothalamus (VHT) integrates several physiological cues to maintain glucose homeostasis and energy balance. Aging is associated with increased glucose intolerance but the underlying mechanisms responsible for age-related metabolic decline, including neuronal signaling in the VHT, remain elusive. We have s...

journal_title：Aging

authors： Sato K,Idelevich A,Nagano K,Rowe GC,Gori F,Baron R

更新日期：2017-01-20 00:00:00

abstract：:Growing evidence highlighted the tumor mutational burden (TMB) as an important feature of carcinogenesis and therapeutic efficacy in esophageal cancer (EC). Our study aimed to explore the genomic landscape and the correlation between TMB and immune cell infiltration in EC patients with or without radiotherapy. The EC ...

journal_title：Aging

authors： Yuan C,Xiang L,Cao K,Zhang J,Luo Y,Sun W,Zhang N,Ren J,Zhang J,Gong Y,Xie C

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...

journal_title：Aging

authors： Xu D,Chi G,Xu D

更新日期：2020-11-04 00:00:00

abstract：:Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 expose...

journal_title：Aging

authors： Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

更新日期：2021-01-19 00:00:00

abstract：:Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...

journal_title：Aging

authors： Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

更新日期：2020-05-14 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

journal_title：Aging

authors： Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

更新日期：2020-12-09 00:00:00

abstract：:Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

journal_title：Aging

authors： Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

更新日期：2019-05-29 00:00:00

abstract：:Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

journal_title：Aging

authors： Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

更新日期：2019-09-12 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

journal_title：Aging

authors： Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

更新日期：2020-12-30 00:00:00

abstract：:TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

journal_title：Aging

authors： Zhang T,Zhao Y,Zhao Y,Zhou J

更新日期：2020-03-25 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies worldwide with limited treatment options and distinct geographical distribution even in countries such as China. Genetic alterations during its carcinogenesis need urgent elucidation. In this study, we propose an intriguing hypothesis that the hepatitis B X-in...

journal_title：Aging

authors： Yang Z,Jiang X,Li D,Jiang X

更新日期：2020-10-13 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...

journal_title：Aging

authors： Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

更新日期：2020-07-02 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...

journal_title：Aging

authors： Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

更新日期：2020-11-18 00:00:00

abstract：:Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...

journal_title：Aging

authors： Villota C,Varas-Godoy M,Jeldes E,Campos A,Villegas J,Borgna V,Burzio LO,Burzio VA

更新日期：2018-12-30 00:00:00

abstract：:For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...

journal_title：Aging

authors： Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

更新日期：2020-11-16 00:00:00

abstract：:Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...

journal_title：Aging

authors： Huang H,Liu R,Huang Y,Feng Y,Fu Y,Chen L,Chen Z,Cai Y,Zhang Y,Chen Y

更新日期：2020-07-17 00:00:00

abstract：:Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...

journal_title：Aging

authors： Yang Y,Jia Y,Sun Q,Dong H,Zhao R

更新日期：2019-03-28 00:00:00

abstract：:DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis. Although a few...

journal_title：Aging

authors： Zhang TJ,Zhang LC,Xu ZJ,Zhou JD

更新日期：2020-06-26 00:00:00

abstract：:Increased activation of catabolic pathways, including apoptosis causes sarcopenia. However, the precise molecular mechanism that initiates apoptosis during aging is not well understood. Here, we report that aging alters miRNA expression profile in mouse skeletal muscle as evidenced by miRNA microarray and real-time PC...

journal_title：Aging

authors： Pardo PS,Hajira A,Boriek AM,Mohamed JS

更新日期：2017-03-22 00:00:00

abstract：:Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system re...

journal_title：Aging

authors： Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

更新日期：2020-11-24 00:00:00

abstract：:Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. ...

journal_title：Aging

authors： Gat-Yablonski G,Finka A,Pinto G,Quadroni M,Shtaif B,Goloubinoff P

更新日期：2016-08-01 00:00:00

abstract：:Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...

journal_title：Aging

authors： Ma X,Bian Y,Yuan H,Chen N,Pan Y,Zhou W,Gao S,Du X,Hao S,Yan Z,Li X,Liu K,Xu F,Wang Y,Du Y

更新日期：2020-05-20 00:00:00