Abstract:
:DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth inhibition. With such misconceptions, cellular senescence cannot be linked to organismal aging. Also, the relation between cancer and senescence is distorted. Here I discuss why the link between arrest and senescence is semi-coincidental and how senescence is related to aging and cancer.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Blagosklonny MVdoi
10.18632/aging.100281subject
Has Abstractpub_date
2011-02-01 00:00:00pages
94-101issue
2issn
1945-4589pii
100281journal_volume
3pub_type
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