Abstract:
:Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Wong RCB,Lim SY,Hung SSC,Jackson S,Khan S,Van Bergen NJ,De Smit E,Liang HH,Kearns LS,Clarke L,Mackey DA,Hewitt AW,Trounce IA,Pébay Adoi
10.18632/aging.101231subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1341-1350issue
4issn
1945-4589pii
101231journal_volume
9pub_type
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