Abstract:
:In pace with the development of gene sequencing technology and transcriptome research, it has been found that 70 to 90% of the human genome is transcribed into RNAs, while only 2% of RNAs encode proteins. This implies that non-coding RNAs (ncRNAs) may exert vital biological functions and a full analysis of non-coding transcriptomes is needed. Over the past decade, the advance in high-throughput sequencing and transcriptome profiling has enabled the identification of circular RNAs (circRNAs) involved in many biological processes and the occurrence and development of diseases. Accumulating evidence has revealed that circRNAs may serve as new biomarkers for diagnosis as well as provide promising therapeutic approaches and novel drug screening strategies for leukemia. A comprehensive understanding of circRNAs in leukemia is a prerequisite for the development of clinical translational research. In this review, we will discuss the general information of circRNAs and focus on the current advances in understanding the association between dysregulated circRNAs and leukemia.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Wu Z,Sun H,Li J,Jin Hdoi
10.18632/aging.102091subject
Has Abstractpub_date
2019-07-15 00:00:00pages
4757-4771issue
13issn
1945-4589pii
102091journal_volume
11pub_type
杂志文章,评审相关文献
Aging-US文献大全abstract::The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101498
更新日期:2018-07-16 00:00:00
abstract::Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101077
更新日期:2016-10-18 00:00:00
abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101948
更新日期:2019-05-07 00:00:00
abstract::Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101867
更新日期:2019-03-26 00:00:00
abstract::We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specifically, we pursued the simultaneous youthful in vivo calibration of two determinan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102148
更新日期:2019-08-15 00:00:00
abstract::Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101070
更新日期:2016-10-16 00:00:00
abstract::The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechani...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100132
更新日期:2010-03-01 00:00:00
abstract::Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100105
更新日期:2009-12-12 00:00:00
abstract::The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101669
更新日期:2018-12-08 00:00:00
abstract::Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103043
更新日期:2020-04-23 00:00:00
abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101065
更新日期:2016-10-14 00:00:00
abstract::Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102315
更新日期:2019-09-28 00:00:00
abstract::Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104179
更新日期:2020-11-13 00:00:00
abstract::Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HS...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101423
更新日期:2018-04-25 00:00:00
abstract::Family with sequence similarity 83, member A (FAM83A), as a potential tumor promoter, was reported to contribute to the progression of several malignant tumors. However, the significance of FAM83A in invasion and metastasis of non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that FAM...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102163
更新日期:2019-08-24 00:00:00
abstract::Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the fli...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101417
更新日期:2018-04-19 00:00:00
abstract::Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100654
更新日期:2014-04-01 00:00:00
abstract::In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103391
更新日期:2020-10-20 00:00:00
abstract::In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poorer prognosis in CRC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103334
更新日期:2020-06-21 00:00:00
abstract::Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101975
更新日期:2019-05-29 00:00:00
abstract::Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103650
更新日期:2020-08-15 00:00:00
abstract::We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.102788
更新日期:2020-02-07 00:00:00
abstract::The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103527
更新日期:2020-06-30 00:00:00
abstract::The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100366
更新日期:2011-08-01 00:00:00
abstract::Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.102475
更新日期:2019-11-25 00:00:00
abstract::Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103878
更新日期:2020-10-29 00:00:00
abstract::Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, with a high fatality rate. To date, there is no model to predict the severity of COVID-19 in elderly patients. In this study, patients who maintained a non-severe condition and patients who progressed to ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103980
更新日期:2020-11-10 00:00:00
abstract::Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102360
更新日期:2019-10-16 00:00:00
abstract::How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104051
更新日期:2020-11-18 00:00:00
abstract::Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death. Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain damage under ischemic conditions. Mitophagy is a mechanism by which damaged mitochondria are removed by autophagy to maintain mitochondrial structure...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102899
更新日期:2020-03-10 00:00:00