Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.

abstract：BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...

journal_title：Aging

authors： Wu C,Chen R,Xu L,Chen Y,Wang Y,Huang G,Liu J

更新日期：2020-07-08 00:00:00

abstract：:One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...

journal_title：Aging

authors： Obukhova LA,Skulachev VP,Kolosova NG

更新日期：2009-04-22 00:00:00

abstract：:Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swe...

journal_title：Aging

authors： Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar S

更新日期：2020-12-21 00:00:00

abstract：:In this meta-analysis, we systematically investigated the correlation between single nucleotide polymorphisms (SNPs) and pancreatic cancer (PC) risk. We searched PubMed, Network Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), an...

journal_title：Aging

authors： Ye ZM,Li LJ,Luo MB,Qing HY,Zheng JH,Zhang C,Lu YX,Tang YM

更新日期：2020-11-20 00:00:00

abstract：:This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

journal_title：Aging

authors： Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

更新日期：2021-01-20 00:00:00

abstract：:Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...

journal_title：Aging

authors： Kato K,Zweig R,Schechter CB,Verghese J,Barzilai N,Atzmon G

更新日期：2013-03-01 00:00:00

abstract：:Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to pl...

journal_title：Aging

authors： Evola CM,Hudson TL,Huang L,Corbett AM,Mayes DA

更新日期：2018-08-31 00:00:00

abstract：:Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the esta...

journal_title：Aging

authors： Xu W,Zhang C,Li JQ,Tan CC,Cao XP,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-05-22 00:00:00

abstract：:Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in B...

journal_title：Aging

authors： Wang L,Li H,Qiao Q,Ge Y,Ma L,Wang Q

更新日期：2020-11-07 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...

journal_title：Aging

authors： Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

更新日期：2020-07-02 00:00:00

abstract：:Mesenchymal-to-endothelial transition (MEndT) is one of the mechanisms that influences cardiac fibrosis, which is a key process in cardiac remodeling. It has been reported that autophagy inhibits endothelial cell transition. However, whether autophagy could modulate MEndT in cardiac fibrosis has not yet been investiga...

journal_title：Aging

authors： Hu J,Kong S,Dong T,Lin Z,Zhang Q,Chen X,Gong Y,Fan X,He M,Zhou H

更新日期：2020-11-13 00:00:00

abstract：:Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...

journal_title：Aging

authors： Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

更新日期：2012-10-01 00:00:00

abstract：:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

journal_title：Aging

authors： Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

更新日期：2019-02-05 00:00:00

abstract：:Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

journal_title：Aging

authors： Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

更新日期：2019-09-12 00:00:00

abstract：:Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...

journal_title：Aging

authors： Fujie S,Hasegawa N,Sanada K,Hamaoka T,Maeda S,Padilla J,Martinez-Lemus LA,Iemitsu M

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is important in tumor invasiveness and metastasis. We aimed to determine prognostic value of six key EMT markers (CDH1, CDH2, SNAI1, SNAI2, VIM, TWIST1) in clear cell renal cell carcinoma (ccRCC). A total of 533 ccRCC patients with RNASeq data from The Cancer Genome Atlas (TC...

journal_title：Aging

authors： Xu H,Xu WH,Ren F,Wang J,Wang HK,Cao DL,Shi GH,Qu YY,Zhang HL,Ye DW

更新日期：2020-01-08 00:00:00

abstract：:Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese po...

journal_title：Aging

authors： Gao XL,Jia ZM,Zhao FF,An DD,Wang B,Cheng EJ,Chen Y,Gong JN,Liu D,Huang YQ,Yang JJ,Wang SJ

更新日期：2020-02-29 00:00:00

abstract：:SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulate...

journal_title：Aging

authors： Liu A,Zhang S,Li W,Xu B,Lei R,Zhu S

更新日期：2020-01-11 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...

journal_title：Aging

authors： Liao Y,Feng Y,Wang B,Wang H,Huang J,Wu Y,Wu Z,Chen X,Yang C,Fu X,Sun H

更新日期：2020-10-14 00:00:00

abstract：:Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...

journal_title：Aging

authors： Jin D,Zhang R,Chen H,Li C

更新日期：2020-06-13 00:00:00

abstract：:The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

journal_title：Aging

authors： Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

更新日期：2020-11-20 00:00:00

abstract：:There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...

journal_title：Aging

authors： Zarnani K,Nichols TE,Alfaro-Almagro F,Fagerlund B,Lauritzen M,Rostrup E,Smith SM

更新日期：2019-08-26 00:00:00

abstract：:To investigate the association of homocysteine concentration with intracranial atherosclerotic stenosis (ICAS), we assessed 933 acute ischemic stroke patients (346 with ICAS, 587 without ICAS) and 798 non-stroke controls (175 with ICAS, 623 without ICAS) with magnetic resonance angiography (MRA). Homocysteine concentr...

journal_title：Aging

authors： Liu Y,Song JH,Hou XH,Ma YH,Shen XN,Xu W,Sun FR,Dong Q,Yu JT,Tan L,Chi S

更新日期：2019-06-12 00:00:00

abstract：:The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechani...

journal_title：Aging

authors： Blagosklonny MV,Campisi J,Sinclair DA,Bartke A,Blasco MA,Bonner WM,Bohr VA,Brosh RM Jr,Brunet A,Depinho RA,Donehower LA,Finch CE,Finkel T,Gorospe M,Gudkov AV,Hall MN,Hekimi S,Helfand SL,Karlseder J,Kenyon C,Kroeme

更新日期：2010-03-01 00:00:00

abstract：:Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

journal_title：Aging

authors： Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

更新日期：2020-11-26 00:00:00

abstract：:Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...

journal_title：Aging

authors： Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis-related fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher ...

journal_title：Aging

authors： Wang Y,Yang Q,Shen S,Zhang L,Xiang Y,Weng X

更新日期：2020-07-21 00:00:00

abstract：:Hutchinson-Gilford Progeria (HGPS) and Werner syndromes are diseases that clinically resemble some aspects of accelerated aging. HGPS is caused by mutations in theLMNA gene resulting in post-translational processing defects that trigger Progeria in children. Werner syndrome, arising from mutations in the WRN helicase ...

journal_title：Aging

authors： Dreesen O,Stewart CL

更新日期：2011-09-01 00:00:00

abstract：:Multiple sclerosis is among the most serious inflammatory demyelinating diseases (IDD). Interleukin-23A (IL23A) regulates and coordinates the activities of immune cells by interacting with its receptor IL23R and plays key roles in the pathogenesis of immune inflammatory diseases. IDD, deemed to be a kind of autoimmune...

journal_title：Aging

authors： Li FF,Zhu XD,Yan P,Jin MH,Yue H,Zhang Q,Fu J,Liu SL

更新日期：2016-11-26 00:00:00