Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

abstract：OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...

journal_title：Aging

authors： Chen K,Li L,Qu S,Pan X,Sun Y,Wan F,Yu B,Zhou L,Zhu X

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...

journal_title：Aging

authors： Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

更新日期：2019-10-31 00:00:00

abstract：:The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...

journal_title：Aging

authors： Wang H,Guo B,Hui Q,Lin F,Tao K

更新日期：2020-04-20 00:00:00

abstract：:Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP). There are contrasting studies on the role of the SASP in cancer. Studies suggested that cancer cells may misuse the senescent secretome for their growth. Other investig...

journal_title：Aging

authors： Alessio N,Aprile D,Squillaro T,Di Bernardo G,Finicelli M,Melone MA,Peluso G,Galderisi U

更新日期：2019-08-14 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...

journal_title：Aging

authors： Chen Y,Li J,Ma B,Li N,Wang S,Sun Z,Xue C,Han Q,Wei J,Zhao RC

更新日期：2020-09-23 00:00:00

abstract：:Qigesan (QGS) has been used to effectively treat esophageal cancer (EC) for decades in China, but the mechanism by which it suppresses EC metastasis remains unknown. In this study, we examined the effects of QGS on EC cell mobility. Using immunohistochemistry and immunofluorescence, expression of Gas6 and Axl, which p...

journal_title：Aging

authors： Kong L,Lu X,Chen X,Wu Y,Zhang Y,Shi H,Li J

更新日期：2020-05-20 00:00:00

abstract：:DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis. Although a few...

journal_title：Aging

authors： Zhang TJ,Zhang LC,Xu ZJ,Zhou JD

更新日期：2020-06-26 00:00:00

abstract：:Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

journal_title：Aging

authors： Chen Y,Fu D,Zhao H,Cheng W,Xu F

更新日期：2020-05-21 00:00:00

abstract：AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...

journal_title：Aging

authors： Siu CW,Lee YK,Ho JC,Lai WH,Chan YC,Ng KM,Wong LY,Au KW,Lau YM,Zhang J,Lay KW,Colman A,Tse HF

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...

journal_title：Aging

authors： Zhu Y,Bo H,Chen Z,Li J,He D,Xiao M,Xiang L,Jin L,Zhou J,Gong L,Zhou Y,Zhou M,Xiong W,Xing X,Li R,Cao K

更新日期：2020-11-04 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

journal_title：Aging

authors： Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

更新日期：2020-12-09 00:00:00

abstract：:Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized. While demonstrating that CCs promoted oocyte aging by releasing soluble Fas ligand (sFasL), our recent study suggested that CCs might secrete other factors to med...

journal_title：Aging

authors： Kong QQ,Wang J,Xiao B,Lin FH,Zhu J,Sun GY,Luo MJ,Tan JH

更新日期：2018-07-26 00:00:00

abstract：BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...

journal_title：Aging

authors： Yerrakalva D,Hajna S,Wijndaele K,Westgate K,Khaw KT,Wareham N,Griffin SJ,Brage S

更新日期：2021-01-11 00:00:00

abstract：:Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H2O2 induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA damage response (DDR) acti...

journal_title：Aging

authors： Borodkina A,Shatrova A,Abushik P,Nikolsky N,Burova E

更新日期：2014-06-01 00:00:00

abstract：:Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...

journal_title：Aging

authors： Cui Y,Song Y,Yan S,Cao M,Huang J,Jia D,Liu Y,Zhang S,Fan W,Cai L,Li C,Xing Y

更新日期：2020-10-25 00:00:00

abstract：:Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...

journal_title：Aging

authors： Rajapakse D,Chen M,Curtis TM,Xu H

更新日期：2017-10-09 00:00:00

abstract：:Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 from a cohort of 1579 East Asian indiv...

journal_title：Aging

authors： Li T,Quan H,Zhang H,Lin L,Lin L,Ou Q,Chen K

更新日期：2020-06-12 00:00:00

abstract：:Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche. However, among the six isoforms, the isoforms providing tumor microenvironment and their regulatory network are still unclarified. Based on bioinformatics analysis of hundreds of HCC transcriptome datasets from public databases, we...

journal_title：Aging

authors： Liu Y,Zhang J,Chen Y,Sohel H,Ke X,Chen J,Li YX

更新日期：2020-01-05 00:00:00

abstract：:Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

journal_title：Aging

authors： Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

更新日期：2018-10-11 00:00:00

abstract：:Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...

journal_title：Aging

authors： Wu Y,Pei Y,Yang Z,Li K,Lou X,Cui W

更新日期：2020-10-29 00:00:00

abstract：:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. W...

journal_title：Aging

authors： Hur JH,Cho J,Walker DW

更新日期：2010-01-26 00:00:00

abstract：:Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...

journal_title：Aging

authors： Li Y,Dai Z,Huang G,Jin Y,Ning Z,Shen J

更新日期：2020-01-12 00:00:00

abstract：:The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apopt...

journal_title：Aging

authors： Zhang N,Xing Y,Yu Y,Liu C,Jin B,Huo L,Kong D,Yang Z,Zhang X,Zheng R,Jia Z,Kang L,Zhang W

更新日期：2020-05-28 00:00:00

abstract：:Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...

journal_title：Aging

authors： Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

更新日期：2020-08-29 00:00:00

abstract：:Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...

journal_title：Aging

authors： Zhu L,Zhong Q,Yang T,Xiao X

更新日期：2019-12-21 00:00:00

abstract：:Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...

journal_title：Aging

authors： Baehr LM,West DW,Marcotte G,Marshall AG,De Sousa LG,Baar K,Bodine SC

更新日期：2016-01-01 00:00:00

abstract：:Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation. Oxidative stress plays a role in the pathogenesis of osteoporosis. Aucubin (AU), an iridoid glycoside, was previously shown to promote osteoblast differentiation. We investigated the effects of AU on MG63 human o...

journal_title：Aging

authors： Li Y,Zhang Y,Zhang X,Lu W,Liu X,Hu M,Wang D

更新日期：2020-02-05 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：:Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvest...

journal_title：Aging

authors： Xia B,de Belle JS

更新日期：2016-05-01 00:00:00

abstract：:There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...

journal_title：Aging

authors： Zarnani K,Nichols TE,Alfaro-Almagro F,Fagerlund B,Lauritzen M,Rostrup E,Smith SM

更新日期：2019-08-26 00:00:00