Abstract:
:Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation. Oxidative stress plays a role in the pathogenesis of osteoporosis. Aucubin (AU), an iridoid glycoside, was previously shown to promote osteoblast differentiation. We investigated the effects of AU on MG63 human osteoblast-like cells treated with dexamethasone (Dex) or hydrogen peroxide (H2O2) to induce oxidative damage. AU protected MG63 cells against apoptosis, and promoted increased expression of cytokines associated with osteoblast differentiation, including collagen I, osteocalcin (OCN), osteopontin (OPN), and osterix. In Dex- and H2O2-treated MG63 cells, AU also enhanced the expression of anti-oxidative stress-associated factors in the nuclear respiratory factor 2 signaling pathway, including superoxide dismutases 1 and 2, heme oxygenases 1 and 2, and catalase. In vivo, using a Dex-induced mouse model of osteoporosis, AU promoted increased cortical bone thickness, increased bone density, and tighter trabecular bone. Additionally, it stimulated an increase in the expression of collagen I, OCN, OPN, osterix, and phosphorylated Akt and Smads in bone tissue. Finally, AU stimulated the expression of cytokines associated with osteoblast differentiation in bone tissue and serum. Our data indicate AU may have therapeutic efficacy in osteoporosis.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Li Y,Zhang Y,Zhang X,Lu W,Liu X,Hu M,Wang Ddoi
10.18632/aging.102742subject
Has Abstractpub_date
2020-02-05 00:00:00pages
2226-2245issue
3issn
1945-4589pii
102742journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202174
更新日期:2020-11-25 00:00:00
abstract::Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101767
更新日期:2019-01-30 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101790
更新日期:2019-02-06 00:00:00
abstract::According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202382
更新日期:2021-01-10 00:00:00
abstract::Docetaxel is a first-line anticancer drug widely used in the treatment of advanced prostate cancer. However, its therapeutic efficacy is limited by its side effects and the development of chemoresistance by the tumor. Using a gene differential expression microarray, we identified 449 genes differentially expressed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102600
更新日期:2019-12-29 00:00:00
abstract::The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101498
更新日期:2018-07-16 00:00:00
abstract::The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104123
更新日期:2020-11-20 00:00:00
abstract::Inhalation anesthetics have been demonstrated to have protective effects against myocardial ischemia reperfusion injury (MIRI). O-linked GlcNAcylation (O-GlcNAc) modifications have been shown to protect against MIRI. This study aimed to investigate whether O-GlcNAcylation and necroptosis signaling were important for s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104146
更新日期:2020-11-20 00:00:00
abstract::Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103276
更新日期:2020-05-21 00:00:00
abstract::Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101081
更新日期:2016-12-08 00:00:00
abstract::Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102817
更新日期:2020-02-19 00:00:00
abstract::Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102529
更新日期:2019-12-20 00:00:00
abstract:BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103352
更新日期:2020-07-08 00:00:00
abstract::In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis-related fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103643
更新日期:2020-07-21 00:00:00
abstract:PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103111
更新日期:2020-04-22 00:00:00
abstract::The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100928
更新日期:2016-04-01 00:00:00
abstract::Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes, thereby contributing to the development and progression of osteoarthritis (OA). Here, we investigated the effects of IL-18 treatment and inhibition in rat chondrocytes in vitro and in vivo. We used RT-PCR and Western blotting to measure the mR...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102937
更新日期:2020-03-17 00:00:00
abstract::Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103692
更新日期:2020-09-23 00:00:00
abstract::Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104078
更新日期:2020-11-18 00:00:00
abstract::Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103669
更新日期:2021-01-05 00:00:00
abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101908
更新日期:2019-04-14 00:00:00
abstract::Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202305
更新日期:2020-12-19 00:00:00
abstract::Advanced age and apolipoprotein E (APOE) ε4 allele are both associated with increased risk of the Alzheimer's disease (AD). However, the extent of the joint contribution of APOE ε4 allele and age on the brain white matter integrity, cognition and their relationship are unclear. We assessed the age-related variation di...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103367
更新日期:2020-06-22 00:00:00
abstract::Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100668
更新日期:2014-06-01 00:00:00
abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103939
更新日期:2020-10-13 00:00:00
abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202302
更新日期:2020-12-03 00:00:00
abstract::Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101671
更新日期:2018-12-06 00:00:00
abstract::Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100526
更新日期:2012-12-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102377
更新日期:2019-10-30 00:00:00