Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis.

abstract：BACKGROUND:Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Long noncoding RNA ANRIL (lncRNA-ANRIL) is critical in vascular homeostasis. Metformin produces multiple beneficial effects in atherosclerosis. However, the underlying mechanisms need to be elucidated. METHODS ...

journal_title：Aging

authors： Hu DJ,Li ZY,Zhu YT,Li CC

更新日期：2020-12-19 00:00:00

abstract：:Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...

journal_title：Aging

authors： Hou Y,Hu Z,Gong X,Yang B

更新日期：2020-09-04 00:00:00

abstract：:N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...

journal_title：Aging

authors： Shaposhnikov MV,Zemskaya NV,Koval LA,Schegoleva EV,Zhavoronkov A,Moskalev AA

更新日期：2018-09-20 00:00:00

abstract：:Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

journal_title：Aging

authors： Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

更新日期：2020-11-26 00:00:00

abstract：:In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported th...

journal_title：Aging

authors： Halicka HD,Zhao H,Li J,Traganos F,Studzinski GP,Darzynkiewicz Z

更新日期：2012-04-01 00:00:00

abstract：:Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...

journal_title：Aging

authors： Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

更新日期：2019-02-24 00:00:00

abstract：:In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...

journal_title：Aging

authors： Jiang X,Chen D

更新日期：2020-10-20 00:00:00

abstract：:For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...

journal_title：Aging

authors： Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

更新日期：2020-11-16 00:00:00

abstract：:Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

journal_title：Aging

authors： Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

更新日期：2019-09-12 00:00:00

abstract：:Patients with end-stage renal disease (ESRD) display phenotypic features of premature biological aging, characterized by disproportionately high morbidity and mortality at a younger age. Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is...

journal_title：Aging

authors： Sumida K,Han Z,Dashputre AA,Potukuchi PK,Kovesdy CP

更新日期：2020-07-13 00:00:00

abstract：:How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...

journal_title：Aging

authors： Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

更新日期：2020-11-18 00:00:00

abstract：:Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins ...

journal_title：Aging

authors： Pomatto LCD,Wong S,Carney C,Shen B,Tower J,Davies KJA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

journal_title：Aging

authors： Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

更新日期：2019-02-02 00:00:00

abstract：:Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swe...

journal_title：Aging

authors： Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar S

更新日期：2020-12-21 00:00:00

abstract：:To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...

journal_title：Aging

authors： Xu F,Zhang Q,Wang H

更新日期：2020-07-25 00:00:00

abstract：:Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...

journal_title：Aging

authors： Ali S,Liu X,Queen NJ,Patel RS,Wilkins RK,Mo X,Cao L

更新日期：2019-04-29 00:00:00

abstract：:Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillat...

journal_title：Aging

authors： Liu L,Song C,Li J,Wang Q,Zhu M,Hu Y,Chen J,Chen C,Zhang JS,Dong N,Chen C

更新日期：2020-01-20 00:00:00

abstract：:We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment o...

journal_title：Aging

authors： Kearney AY,Anchang B,Plevritis S,Felsher DW

更新日期：2015-09-01 00:00:00

abstract：:Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

journal_title：Aging

authors： Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

更新日期：2019-11-13 00:00:00

abstract：:Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...

journal_title：Aging

authors： Fujie S,Hasegawa N,Sanada K,Hamaoka T,Maeda S,Padilla J,Martinez-Lemus LA,Iemitsu M

更新日期：2020-01-09 00:00:00

abstract：:Multiple sclerosis is among the most serious inflammatory demyelinating diseases (IDD). Interleukin-23A (IL23A) regulates and coordinates the activities of immune cells by interacting with its receptor IL23R and plays key roles in the pathogenesis of immune inflammatory diseases. IDD, deemed to be a kind of autoimmune...

journal_title：Aging

authors： Li FF,Zhu XD,Yan P,Jin MH,Yue H,Zhang Q,Fu J,Liu SL

更新日期：2016-11-26 00:00:00

abstract：:Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphism...

journal_title：Aging

authors： Montesanto A,Bonfigli AR,Crocco P,Garagnani P,De Luca M,Boemi M,Marasco E,Pirazzini C,Giuliani C,Franceschi C,Passarino G,Testa R,Olivieri F,Rose G

更新日期：2018-02-04 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：:Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...

journal_title：Aging

authors： Huang JL,Yu C,Su M,Yang SM,Zhang F,Chen YY,Liu JY,Jiang YF,Zhong ZG,Wu DP

更新日期：2019-10-07 00:00:00

abstract：:Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...

journal_title：Aging

authors： Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

更新日期：2019-09-28 00:00:00

abstract：:Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese po...

journal_title：Aging

authors： Gao XL,Jia ZM,Zhao FF,An DD,Wang B,Cheng EJ,Chen Y,Gong JN,Liu D,Huang YQ,Yang JJ,Wang SJ

更新日期：2020-02-29 00:00:00

abstract：:TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

journal_title：Aging

authors： Zhang T,Zhao Y,Zhao Y,Zhou J

更新日期：2020-03-25 00:00:00

abstract：:Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

journal_title：Aging

authors： Guest I,Ilic Z,Scrable H,Sell S

更新日期：2015-12-01 00:00:00

abstract：:The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...

journal_title：Aging

authors： Yang L,Fu Q,Miao L,Ding Q,Li X,Wang J,Jiang G,Wang Y

更新日期：2020-05-05 00:00:00

abstract：:The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

journal_title：Aging

authors： Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

更新日期：2020-01-21 00:00:00