Abstract:
:Family with sequence similarity 83, member A (FAM83A), as a potential tumor promoter, was reported to contribute to the progression of several malignant tumors. However, the significance of FAM83A in invasion and metastasis of non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that FAM83A expression was significantly increased in NSCLC tissues. High expression of FAM83A was positively associated with tumor metastasis and poor survival of NSCLC patients. Functional experiments revealed that FAM83A knockdown could suppress NSCLC cell migration and invasion both in vivo and in vitro. While opposite results were observed in FAM83A-transfected cells. Mechanically, we found that FAM83A promoted NSCLC cell migration and invasion by inducing epithelial-mesenchymal transition (EMT) via PI3K/ATK/Snail signaling. Rescue experiment demonstrated that inhibition of either AKT or Snail could partially counteract the promoting effect of FAM83A overexpression in NSCLC metastasis. Taken together, our findings are the first time to demonstrate that increased expression of FAM83A in NSCLC was correlated with EMT and tumor metastasis, which may provide a novel therapeutic target in NSCLC treatment.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Zhou F,Geng J,Xu S,Meng Q,Chen K,Liu F,Yang F,Pan B,Yu Ydoi
10.18632/aging.102163subject
Has Abstractpub_date
2019-08-24 00:00:00pages
6069-6088issue
16issn
1945-4589pii
102163journal_volume
11pub_type
杂志文章相关文献
Aging-US文献大全abstract::The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100529
更新日期:2012-12-01 00:00:00
abstract::Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202174
更新日期:2020-11-25 00:00:00
abstract::Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102856
更新日期:2020-02-26 00:00:00
abstract::Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103491
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.202195
更新日期:2020-12-15 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is important in tumor invasiveness and metastasis. We aimed to determine prognostic value of six key EMT markers (CDH1, CDH2, SNAI1, SNAI2, VIM, TWIST1) in clear cell renal cell carcinoma (ccRCC). A total of 533 ccRCC patients with RNASeq data from The Cancer Genome Atlas (TC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102660
更新日期:2020-01-08 00:00:00
abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103465
更新日期:2020-08-05 00:00:00
abstract::Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102315
更新日期:2019-09-28 00:00:00
abstract::The ventral hypothalamus (VHT) integrates several physiological cues to maintain glucose homeostasis and energy balance. Aging is associated with increased glucose intolerance but the underlying mechanisms responsible for age-related metabolic decline, including neuronal signaling in the VHT, remain elusive. We have s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101157
更新日期:2017-01-20 00:00:00
abstract::Di (2-ethylhexyl) phthalate (DEHP), an estrogen-like compound that is a ubiquitous environmental contaminant, has been reported to adversely affect human and mammalian reproduction. Many studies have found that exposure to DEHP during pregnancy perturbs female germ cell meiosis and is detrimental to oogenesis. Previou...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101715
更新日期:2018-12-26 00:00:00
abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202497
更新日期:2021-01-11 00:00:00
abstract::The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103118
更新日期:2020-04-28 00:00:00
abstract::The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103024
更新日期:2020-04-09 00:00:00
abstract:AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100503
更新日期:2012-11-01 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102581
更新日期:2019-12-18 00:00:00
abstract::Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101037
更新日期:2016-09-28 00:00:00
abstract::Aging is associated with impaired angiogenesis and lung alveolar regeneration, which contributes to the increased susceptibility to chronic lung diseases (CLD). We have reported that the Wnt ligand co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), stimulates angiogenesis and lung alveolar regener...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101722
更新日期:2019-01-05 00:00:00
abstract::Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100105
更新日期:2009-12-12 00:00:00
abstract:PURPOSE:To develop a decision tree algorithm-based classification system for personalized management of hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. RESULTS:The HVTT-PVTT score could differentiate two groups of patients (< 3 and ≥ 3 points) with different survival outcomes (7.4 vs 4.6 mo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102403
更新日期:2019-11-03 00:00:00
abstract::Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103276
更新日期:2020-05-21 00:00:00
abstract::Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104179
更新日期:2020-11-13 00:00:00
abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104111
更新日期:2020-10-20 00:00:00
abstract::Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor involved. Here, we provide evidence to support these latter two roles of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103961
更新日期:2020-09-24 00:00:00
abstract::Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100326
更新日期:2011-05-01 00:00:00
abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101908
更新日期:2019-04-14 00:00:00
abstract::TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102928
更新日期:2020-03-25 00:00:00
abstract::An intriguing area of research has demonstrated the ability of extracellular vesicles (EVs) as biological vehicles for microRNAs (miRNAs) transfer. Mesenchymal stem cells (MSCs) produce large amounts of EVs. Rat models of ischemia/reperfusion (I/R) were established to explore the expression profile of thioredoxin-inte...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102792
更新日期:2020-07-13 00:00:00
abstract::Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101117
更新日期:2016-11-30 00:00:00
abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101601
更新日期:2018-10-25 00:00:00