Abstract:
:In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeostasis of extracellular matrix (ECM) metabolism in tert-butyl hydroperoxide (TBHP)-treated chondrocytes. Molecular docking analysis showed a -CDOCKER interaction energy value of 203.76 kcal/mol for interactions between SAC and nuclear factor erythroid 2-related factor 2 (Nrf2). SAC increased the nuclear translocation of Nrf2 and activated the Nrf2/HO1 signaling pathway in TBHP-treated chondrocytes. Furthermore, Nrf2 knockdown abrogated the antiapoptotic, antisenescence, and ECM regulatory effects of SAC in TBHP-treated chondrocytes. SAC treatment also significantly reduced cartilage ossification and erosion, joint-space narrowing, synovial thickening and hypercellularity in DMM model mice. Collectively, these findings show that SAC ameliorates OA pathology in TBHP-treated chondrocytes and DMM model mice by activating the Nrf2/HO1 signaling pathway.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang Xdoi
10.18632/aging.103757subject
Has Abstractpub_date
2020-10-07 00:00:00pages
19254-19272issue
19issn
1945-4589pii
103757journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract:UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100484
更新日期:2012-09-01 00:00:00
abstract::Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101037
更新日期:2016-09-28 00:00:00
abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104028
更新日期:2020-11-16 00:00:00
abstract::Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103137
更新日期:2020-05-11 00:00:00
abstract::Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102765
更新日期:2020-02-06 00:00:00
abstract::Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100958
更新日期:2016-05-01 00:00:00
abstract::Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103901
更新日期:2020-10-11 00:00:00
abstract::Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101671
更新日期:2018-12-06 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102548
更新日期:2019-12-10 00:00:00
abstract::The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103118
更新日期:2020-04-28 00:00:00
abstract::Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100492
更新日期:2012-10-01 00:00:00
abstract::A poor outcome for pancreatic ductal adenocarcinoma (PDAC) patients is still a challenge worldwide. The aim of our study is to investigate the potential of key laminin subunits for being used both as a diagnostic and prognostic biomarker for PDAC patients. We evaluated the mRNA expression and prognostic value of lamin...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102007
更新日期:2019-06-10 00:00:00
abstract::Little is known on how well senescence markers in vitro and in situ correlate within individual donors. We studied correlations between the same and different in vitro markers. Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal f...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101389
更新日期:2018-02-28 00:00:00
abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101855
更新日期:2019-03-12 00:00:00
abstract::Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102657
更新日期:2020-01-12 00:00:00
abstract::Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104122
更新日期:2020-11-12 00:00:00
abstract::Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103044
更新日期:2020-04-14 00:00:00
abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101878
更新日期:2019-03-28 00:00:00
abstract::To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103569
更新日期:2020-07-25 00:00:00
abstract::Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. Caspase recruitment domain family member 6 (CARD6) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102561
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102539
更新日期:2019-12-19 00:00:00
abstract::Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103348
更新日期:2020-06-22 00:00:00
abstract::In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103402
更新日期:2020-07-03 00:00:00
abstract::Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101145
更新日期:2016-12-20 00:00:00
abstract::To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103576
更新日期:2020-07-26 00:00:00
abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102804
更新日期:2020-02-15 00:00:00
abstract::Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100879
更新日期:2016-01-01 00:00:00
abstract::There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102858
更新日期:2020-02-24 00:00:00
abstract::Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system re...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104176
更新日期:2020-11-24 00:00:00
abstract::Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown longevity, anti-aging and metabolic health effects. We previously reported that the LPD has a renoprotective effect against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. However, it is uncle...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102902
更新日期:2020-03-06 00:00:00