Abstract:
:Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular endothelium are particularly susceptible to radiation and play an important role in brain homeostasis, we investigated radiation-induced senescence in brain microvascular endothelial cells (EC). Using biotinylation to label surface proteins, streptavidin enrichment and proteomic analysis, we analyzed the surface proteome of stress-induced senescent EC in culture. An array of both recognized and novel senescence-associated proteins were identified. Most notably, we identified and validated the novel radiation-stimulated down-regulation of the protease, a disintegrin and metalloprotease 10 (ADAM10). ADAM10 is an important modulator of amyloid beta protein production, accumulation of which is central to the pathologies of Alzheimer's disease and cerebral amyloid angiopathy. Concurrently, we identified and validated increased surface expression of ADAM10 proteolytic targets with roles in neural proliferation and survival, inflammation and immune activation (L1CAM, NEO1, NEST, TLR2, DDX58). ADAM10 may be a key molecule linking radiation, senescence and endothelial dysfunction with increased risk of premature neurodegenerative diseases normally associated with aging.
journal_name
Aging (Albany NY)journal_title
Agingauthors
McRobb LS,McKay MJ,Gamble JR,Grace M,Moutrie V,Santos ED,Lee VS,Zhao Z,Molloy MP,Stoodley MAdoi
10.18632/aging.101225subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1248-1268issue
4issn
1945-4589pii
101225journal_volume
9pub_type
杂志文章相关文献
Aging-US文献大全abstract::Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101145
更新日期:2016-12-20 00:00:00
abstract::Epigenetic regulation of various genomic functions, including gene expression, provide mechanisms whereby an organism can dynamically respond to changes in its environment and modify gene expression accordingly. One epigenetic mechanism implicated in human aging and age-related disorders is DNA methylation. Isolated p...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101187
更新日期:2017-02-28 00:00:00
abstract::There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101496
更新日期:2018-07-18 00:00:00
abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.202195
更新日期:2020-12-15 00:00:00
abstract::Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101790
更新日期:2019-02-06 00:00:00
abstract::The C. elegans germline and somatic gonad are actively developing until the animal reaches adulthood, and then continue to undergo striking changes as the animal ages. Reported changes include a depletion of available sperm, a decrease in oocyte quality up till mid-life, a reduction in germline nuclei, a decrease in f...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100448
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102292
更新日期:2019-10-25 00:00:00
abstract::Family with sequence similarity 83, member A (FAM83A), as a potential tumor promoter, was reported to contribute to the progression of several malignant tumors. However, the significance of FAM83A in invasion and metastasis of non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that FAM...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102163
更新日期:2019-08-24 00:00:00
abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102324
更新日期:2019-10-06 00:00:00
abstract::In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poorer prognosis in CRC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103334
更新日期:2020-06-21 00:00:00
abstract::Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103909
更新日期:2020-11-16 00:00:00
abstract::Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103972
更新日期:2020-11-10 00:00:00
abstract::Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donors >60 years of age, we found tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101774
更新日期:2019-01-27 00:00:00
abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103649
更新日期:2020-09-14 00:00:00
abstract:OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103860
更新日期:2020-10-01 00:00:00
abstract::We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100813
更新日期:2015-09-01 00:00:00
abstract::The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100529
更新日期:2012-12-01 00:00:00
abstract::The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103024
更新日期:2020-04-09 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract::To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102216
更新日期:2019-09-03 00:00:00
abstract::Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103882
更新日期:2020-11-05 00:00:00
abstract::Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100526
更新日期:2012-12-01 00:00:00
abstract::Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103043
更新日期:2020-04-23 00:00:00
abstract::Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100545
更新日期:2013-03-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is a highly malignant tumor. Many circular RNAs (circRNAs) are reportedly in regulating the progression of NSCLC. To identify potential therapeutic targets for NSCLC, we conducted a bioinformatics analysis of circRNAs differentially expressed between NSCLC tissues and adjacent normal...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103472
更新日期:2020-07-18 00:00:00
abstract::Reduced Na+-K+-ATPase function is reported in various renal diseases. This implies that increase of Na+-K+-ATPase function may be a new target in treatment of renal injury. We previously reported that Na+-K+-ATPase was stabilized by DRm217, a specific antibody against DR region of Na+-K+-ATPase. In this study, we comp...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101815
更新日期:2019-02-26 00:00:00
abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102300
更新日期:2019-10-17 00:00:00
abstract::Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103277
更新日期:2020-05-20 00:00:00
abstract::The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100319
更新日期:2011-04-01 00:00:00
abstract::Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101923
更新日期:2019-04-29 00:00:00