LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung.


:Aging is associated with impaired angiogenesis and lung alveolar regeneration, which contributes to the increased susceptibility to chronic lung diseases (CLD). We have reported that the Wnt ligand co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), stimulates angiogenesis and lung alveolar regeneration. However, the role of LRP5 in age-related decline in vascular and alveolar morphogenesis remains unclear. In this report, we have demonstrated that vascular and alveolar structures are disrupted in the 24-month (24M) old mouse lungs. The expression of LRP5 and the major angiogenic factors, VEGFR2 and Tie2, is lower in endothelial cells (ECs) isolated from 24M old mouse lungs compared to those from 2M old mouse lungs. Vascular and alveolar formation is attenuated in the hydrogel implanted on the 24M old mouse lungs, while overexpression of LRP5, which restores angiogenic factor expression, reverses vascular and alveolar morphogenesis in the gel. Compensatory lung growth after unilateral pneumonectomy is inhibited in 24M old mice, which is reversed by overexpression of LRP5. These results suggest that LRP5 mediates age-related inhibition of angiogenesis and alveolar morphogenesis. Modulation of LRP5 may be a novel intervention to rejuvenate regenerative ability in aged lung and will lead to the development of efficient strategies for aging-associated CLD.


Aging (Albany NY)




Mammoto A,Muyleart M,Mammoto T




Has Abstract


2019-01-05 00:00:00














  • Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age.

    abstract::Aged subjects display increased susceptibility to mucosal diseases. Retinoic Acid (RA) plays a major role in inducing tolerance in the mucosa. RA acts on Dendritic cells (DCs) to induce mucosal tolerance. Here we compared the response of DCs from aged and young individuals to RA with a view to understand the role of D...


    pub_type: 杂志文章


    authors: Agrawal S,Ganguly S,Tran A,Sundaram P,Agrawal A

    更新日期:2016-06-01 00:00:00

  • Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.

    abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...


    pub_type: 杂志文章


    authors: Ren W,Guan W,Zhang J,Wang F,Xu G

    更新日期:2019-04-14 00:00:00

  • LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.

    abstract::Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...


    pub_type: 杂志文章


    authors: Liu Y,Ma L,Shangguan F,Zhao X,Wang W,Gao Z,Zhou H,Qu G,Huang Y,An J,Xue J,Yang S,Cao Q

    更新日期:2020-09-05 00:00:00

  • Eryptosis as a marker of Parkinson's disease.

    abstract::A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...


    pub_type: 杂志文章


    authors: Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

    更新日期:2014-10-01 00:00:00

  • A novel six-microRNA-based model to improve prognosis prediction of breast cancer.

    abstract::Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...


    pub_type: 杂志文章


    authors: Lai J,Wang H,Pan Z,Su F

    更新日期:2019-01-30 00:00:00

  • Analysis of liver injury factors in 332 patients with COVID-19 in Shanghai, China.

    abstract:OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...


    pub_type: 杂志文章


    authors: Guo H,Zhang Z,Zhang Y,Liu Y,Wang J,Qian Z,Zou Y,Lu H

    更新日期:2020-10-01 00:00:00

  • Circadian clock associates with tumor microenvironment in thoracic cancers.

    abstract::The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct ...


    pub_type: 杂志文章


    authors: Yang Y,Yuan G,Xie H,Wei T,Zhu D,Cui J,Liu X,Shen R,Zhu Y,Yang X

    更新日期:2019-12-23 00:00:00

  • MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle.

    abstract::Increased activation of catabolic pathways, including apoptosis causes sarcopenia. However, the precise molecular mechanism that initiates apoptosis during aging is not well understood. Here, we report that aging alters miRNA expression profile in mouse skeletal muscle as evidenced by miRNA microarray and real-time PC...


    pub_type: 杂志文章


    authors: Pardo PS,Hajira A,Boriek AM,Mohamed JS

    更新日期:2017-03-22 00:00:00

  • Delivery of sFIT-1 engineered MSCs in combination with a continuous low-dose doxorubicin treatment prevents growth of liver cancer.

    abstract::One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...


    pub_type: 杂志文章


    authors: Niu J,Wang Y,Wang J,Bin L,Hu X

    更新日期:2016-12-28 00:00:00

  • Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

    abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...


    pub_type: 杂志文章


    authors: Honkonen M,Vääräniemi K,Saijonmaa O,Nyman A,Tikkakoski AJ,Koskela J,Lehtimäki T,Kähönen M,Mustonen J,Fyhrquist F,Pörsti I

    更新日期:2020-06-23 00:00:00

  • Aging: Dial M for Mitochondria.

    abstract::A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. W...


    pub_type: 杂志文章,评审


    authors: Hur JH,Cho J,Walker DW

    更新日期:2010-01-26 00:00:00

  • Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin.

    abstract::Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive oxygen species (ROS) have been shown to cause cellular senescence in culture, and a...


    pub_type: 杂志文章


    authors: Velarde MC,Flynn JM,Day NU,Melov S,Campisi J

    更新日期:2012-01-01 00:00:00

  • NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma.

    abstract::Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...


    pub_type: 杂志文章


    authors: Zhou WJ,Wang HY,Zhang J,Dai HY,Yao ZX,Zheng Z,Meng-Yan S,Wu K

    更新日期:2020-11-16 00:00:00

  • RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer.

    abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...


    pub_type: 杂志文章


    authors: Liao F,Chen X,Peng P,Dong W

    更新日期:2020-10-08 00:00:00

  • Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...


    pub_type: 杂志文章


    authors: Xu W,Zou H,Wei Z,Song C,Tang C,Yin X,Wang Y,Han S,Cai Y,Han W

    更新日期:2019-06-06 00:00:00

  • Atorvastatin reduces cerebral vasospasm and infarction after aneurysmal subarachnoid hemorrhage in elderly Chinese adults.

    abstract::We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...


    pub_type: 杂志文章,随机对照试验


    authors: Chen J,Li M,Zhu X,Chen L,Yang S,Zhang C,Wu T,Feng X,Wang Y,Chen Q

    更新日期:2020-02-07 00:00:00

  • HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes.

    abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...


    pub_type: 杂志文章


    authors: Villota C,Varas-Godoy M,Jeldes E,Campos A,Villegas J,Borgna V,Burzio LO,Burzio VA

    更新日期:2018-12-30 00:00:00

  • Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling.

    abstract::Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...


    pub_type: 杂志文章


    authors: Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

    更新日期:2021-01-20 00:00:00

  • Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort.

    abstract::Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...


    pub_type: 杂志文章


    authors: Liu WR,Li CY,Xu WH,Liu XJ,Tang HD,Huang HN

    更新日期:2020-07-13 00:00:00

  • MicroRNA-214-3p targets the PLAGL2-MYH9 axis to suppress tumor proliferation and metastasis in human colorectal cancer.

    abstract::Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...


    pub_type: 杂志文章


    authors: Zhou Z,Wu L,Liu Z,Zhang X,Han S,Zhao N,Bao H,Yuan W,Chen J,Ji J,Shu X

    更新日期:2020-05-15 00:00:00

  • Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.

    abstract::Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...


    pub_type: 杂志文章


    authors: Bartley JM,Pan SJ,Keilich SR,Hopkins JW,Al-Naggar IM,Kuchel GA,Haynes L

    更新日期:2016-04-01 00:00:00

  • Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study.

    abstract::Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the esta...


    pub_type: 杂志文章


    authors: Xu W,Zhang C,Li JQ,Tan CC,Cao XP,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2019-05-22 00:00:00

  • Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging.

    abstract::Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...


    pub_type: 杂志文章


    authors: Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

    更新日期:2012-10-01 00:00:00

  • Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

    abstract::Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...


    pub_type: 杂志文章


    authors: Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

    更新日期:2016-05-01 00:00:00

  • Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity.

    abstract::New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct P...


    pub_type: 杂志文章


    authors: Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA

    更新日期:2020-01-04 00:00:00

  • A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation.

    abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...


    pub_type: 杂志文章


    authors: Wang C,Zhang X,Ling Q,Zheng S,Xu X

    更新日期:2020-12-03 00:00:00

  • The IL1β-HER2-CLDN18/CLDN4 axis mediates lung barrier damage in ARDS.

    abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...


    pub_type: 杂志文章


    authors: Ma X,Yu X,Zhou Q

    更新日期:2020-02-15 00:00:00

  • Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality.

    abstract::Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...


    pub_type: 杂志文章


    authors: Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

    更新日期:2020-06-02 00:00:00

  • Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway.

    abstract::Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillat...


    pub_type: 杂志文章


    authors: Liu L,Song C,Li J,Wang Q,Zhu M,Hu Y,Chen J,Chen C,Zhang JS,Dong N,Chen C

    更新日期:2020-01-20 00:00:00

  • Longitudinal plasma metabolomics of aging and sex.

    abstract::Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...


    pub_type: 杂志文章


    authors: Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

    更新日期:2019-02-24 00:00:00