abstract：:Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...

journal_title：Infection and immunity

authors： Xu B,Luo Q,Gong Y,Li J,Cao J

更新日期：2021-01-25 00:00:00

abstract：:Mutation of purR was previously shown to enhance the virulence of Staphylococcus aureus in a murine sepsis model, and this cannot be fully explained by increased expression of genes within the purine biosynthesis pathway. Rather, the increased production of specific S. aureus virulence factors, including alpha toxin a...

journal_title：Infection and immunity

authors： Alkam D,Jenjaroenpun P,Ramirez AM,Beenken KE,Spencer HJ,Smeltzer MS

更新日期：2021-01-19 00:00:00

abstract：:In Pseudomonas aeruginosa, the second messenger cyclic-di-GMP and Gac/Rsm signaling pathways are associated with the transition from acute to chronic infection. Therefore, identification of the molecular mechanisms that govern lifestyle choice in bacteria is very important. Here, we identified a novel cyclic-di-GMP mo...

journal_title：Infection and immunity

authors： Jiao H,Li F,Wang T,Yam JKH,Yang L,Liang H

更新日期：2021-01-19 00:00:00

abstract：:Cell wall proteins with sialidase activity are involved in carbohydrate assimilation, adhesion to mucosal surfaces, and biofilm formation. Gardnerella spp. inhabit the human vaginal microbiome and encode up to three sialidase enzymes, two of which are suspected to be cell wall associated. Here we demonstrate that the ...

journal_title：Infection and immunity

authors： Kurukulasuriya SP,Patterson MH,Hill JE

更新日期：2020-12-23 00:00:00

abstract：:Mucosa-associated invariant T (MAIT) cells are an innate-like T cell subset in mammals that recognize microbial vitamin B metabolites presented by the evolutionarily conserved major histocompatibility complex class I (MHC I)-related molecule, MR1. Emerging data suggest that MAIT cells may be an attractive target for v...

journal_title：Infection and immunity

authors： Vorkas CK,Levy O,Skular M,Li K,Aubé J,Glickman MS

更新日期：2020-12-15 00:00:00

abstract：:Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella est...

journal_title：Infection and immunity

authors： Loomis WP,Delaney MA,Johnson ML,Cookson BT

更新日期：2020-12-15 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in protection against a primary Chlamydia infection is unclear and was a focus of...

journal_title：Infection and immunity

authors： Shillova N,Howe SE,Hyseni B,Ridgell D,Fisher DJ,Konjufca V

更新日期：2020-12-15 00:00:00

abstract：:Lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control of tuberculosis (TB), the leading cause of death from an infectious agent. Improvement or replacement of the BCG vaccine with one that reliably protects all age-groups is urgent. Concerns ...

journal_title：Infection and immunity

authors： Wang Y,Li Z,Wu S,Fleming J,Li C,Zhu G,Chen B,Ren B,Wang X,Du B,Li P,Hu P,Yang J,Liu Y,Zhou C,Zhang XE,Bi L,Zhang H,Yang J,Zhang Z

更新日期：2020-12-14 00:00:00

abstract：:Natural killer (NK) cells are critically involved in the early immune response against various intracellular pathogens, including Coxiella burnetii and Chlamydia psittaciChlamydia-infected NK cells functionally mature, induce cellular immunity, and protect themselves by killing the bacteria in secreted granules. Here,...

journal_title：Infection and immunity

authors： Matthiesen S,Zaeck L,Franzke K,Jahnke R,Fricke C,Mauermeir M,Finke S,Lührmann A,Knittler MR

更新日期：2020-10-19 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a leading diarrheagenic bacterial pathogen among travelers and children in resource-limited regions. Adherence to host intestinal cells mediated by ETEC fimbriae is believed to be a critical first step in ETEC pathogenesis. These fimbriae are categorized into related classes ...

journal_title：Infection and immunity

authors： Liu Y,Shahabudin S,Farid S,Lee LH,McVeigh AL,Maciel M Jr.,,Poole ST,Broadman M,Prouty MG,Savarino SJ

更新日期：2020-10-19 00:00:00

abstract：:The symptoms of Lyme disease are caused by inflammation induced by species of the Borrelia burgdorferisensu lato complex. The various presentations of Lyme disease in the population suggest that differences exist in the intensity and regulation of the host response to the spirochete. Previous work has described correl...

journal_title：Infection and immunity

authors： Siebers EM,Liedhegner ES,Lawlor MW,Schell RF,Nardelli DT

更新日期：2020-10-19 00:00:00

abstract：:Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic ehrlichiosis. In recent reports, we described substantial advances in developing random and targeted gene disruption methods to investigate the functions of E. chaffeensis genes. We reported earlier that the Hima...

journal_title：Infection and immunity

authors： Wang Y,Nair ADS,Alhassan A,Jaworski DC,Liu H,Trinkl K,Hove P,Ganta CK,Burkhardt N,Munderloh UG,Ganta RR

更新日期：2020-09-18 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections. These bacteria undertake a multistage infection cycle involving invasion of and proliferation within urinary tract epithelial cells, leading to the rupture of the host cell and dispersal of the bacteria, some of which have a highly...

journal_title：Infection and immunity

authors： Iosifidis G,Duggin IG

更新日期：2020-08-19 00:00:00

abstract：:Entamoeba histolytica and its reptilian counterpart and encystation model Entamoeba invadens formed a polarized monopodial morphology when treated with pentoxifylline. This morphology was propelled by retrograde flow of the cell surface resulting from a cyclic sol-gel conversion of cytoplasm and a stable bleb at the l...

journal_title：Infection and immunity

authors： Krishnan D,Ghosh SK

更新日期：2020-07-21 00:00:00

abstract：:The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to the OM's ability to function as a molecular permeability barrier tha...

journal_title：Infection and immunity

authors： Giordano NP,Cian MB,Dalebroux ZD

更新日期：2020-06-22 00:00:00

abstract：:Helicobacter pylori colonizes the gastric mucosa and secretes a pore-forming toxin (VacA). Two main types of VacA, m1 and m2, can be distinguished by phylogenetic analysis. Type m1 forms of VacA have been extensively studied, but there has been relatively little study of m2 forms. In this study, we generated H. pylori...

journal_title：Infection and immunity

authors： Caston RR,Sierra JC,Foegeding NJ,Truelock MD,Campbell AM,Frick-Cheng AE,Bimczok D,Wilson KT,McClain MS,Cover TL

更新日期：2020-05-20 00:00:00

abstract：:Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. In addition, B. burgdorferi encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in B. burgdorferi biology remain...

journal_title：Infection and immunity

authors： Thompson C,Mason C,Parrilla S,Ouyang Z

更新日期：2020-05-20 00:00:00

abstract：:Bovine digital dermatitis (BDD), an infectious disease of the bovine foot with a predominant treponemal etiology, is a leading cause of lameness in dairy and beef herds worldwide. BDD is poorly responsive to antimicrobial therapy and exhibits a relapsing clinical course; an effective vaccine is therefore urgently soug...

journal_title：Infection and immunity

authors： Staton GJ,Carter SD,Ainsworth S,Mullin J,Smith RF,Evans NJ

更新日期：2020-04-20 00:00:00

abstract：:Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a corr...

journal_title：Infection and immunity

authors： Eberle KC,Hau SJ,Luan SL,Weinert LA,Stasko JA,Wang J,Peters SE,Langford PR,Rycroft AN,Wren BW,Maskell DJ,Tucker AW,Brockmeier SL

更新日期：2020-04-20 00:00:00

abstract：:Antimicrobial peptides play an important role in host defense against Vibrio cholerae Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strai...

journal_title：Infection and immunity

authors： Samanta P,Mandal RS,Saha RN,Shaw S,Ghosh P,Dutta S,Ghosh A,Imamura D,Morita M,Ohnishi M,Ramamurthy T,Mukhopadhyay AK

更新日期：2020-04-20 00:00:00

abstract：:Human genital Chlamydia infection is a major public health concern due to the serious reproductive system complications. Chlamydia binds several receptor tyrosine kinases (RTKs) on host cells, including the epidermal growth factor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskelet...

journal_title：Infection and immunity

authors： Igietseme JU,Partin J,George Z,Omosun Y,Goldstein J,Joseph K,Ellerson D,Eko FO,Pohl J,Bandea C,Black CM

更新日期：2020-03-23 00:00:00

abstract：:The development of vaccines for prevention of diseases caused by pathogenic species can encounter major obstacles if high sequence diversity is observed between individual strains. Therefore, development might be restricted either to conserved antigens, which are often rare, or to multivalent vaccines, which renders t...

journal_title：Infection and immunity

authors： Nayak A,Schüler W,Seidel S,Gomez I,Meinke A,Comstedt P,Lundberg U

更新日期：2020-03-23 00:00:00

abstract：:Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits the innate immune system to generate a noninflammatory environment during early stages of infection to promote colonization. The ability of Y. pestis to create this early noninflammatory environment is in part due to the ...

journal_title：Infection and immunity

authors： Pulsifer AR,Vashishta A,Reeves SA,Wolfe JK,Palace SG,Proulx MK,Goguen J,Bodduluri SR,Haribabu B,Uriarte SM,Lawrenz MB

更新日期：2020-02-20 00:00:00

abstract：:Neonates are at increased risk for bacterial sepsis. We established that the immune-suppressive cytokine interleukin-27 (IL-27) is elevated in neonatal mice. Similarly, human cord blood-derived macrophages express IL-27 genes and secrete more cytokine than macrophages from adults. In the present work, we hypothesized ...

journal_title：Infection and immunity

authors： Seman BG,Vance JK,Rawson TW,Witt MR,Huckaby AB,Povroznik JM,Bradford SD,Barbier M,Robinson CM

更新日期：2020-02-20 00:00:00

abstract：:While investigating the virulence traits of Staphylococcus aureus adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bov...

journal_title：Infection and immunity

authors： Aziz F,Hisatsune J,Yu L,Kajimura J,Sato'o Y,Ono HK,Masuda K,Yamaoka M,Salasia SIO,Nakane A,Ohge H,Kusunoki Y,Sugai M

更新日期：2020-01-22 00:00:00

abstract：:Cytoadherence-linked asexual gene 9 (Clag9), a conserved Plasmodium protein expressed during the asexual blood stages, is involved in the cytoadherence of infected red blood cells (RBCs) to the endothelial lining of blood vessels. Here, we show that Plasmodium falciparum Clag9 (PfClag9) is a component of the PfClag9-R...

journal_title：Infection and immunity

authors： Chourasia BK,Deshmukh A,Kaur I,Paul G,Panda A,Rathore S,Singh SK,Theisen M,Mohmmed A,Malhotra P

更新日期：2020-01-22 00:00:00

abstract：:The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies that promote fungal killing and also provi...

journal_title：Infection and immunity

authors： Hoy Z,Wright TW,Elliott M,Malone J,Bhagwat S,Wang J,Gigliotti F

更新日期：2020-01-22 00:00:00

abstract：:Antibiotic-resistant Klebsiella pneumoniae isolates constitute a great clinical challenge. One important resistance mechanism in K. pneumoniae is the metallo-β-lactamases (MBLs), which require zinc for their function. Thus, zinc chelation could be a strategy to resensitize K. pneumoniae to β-lactams. However, the pote...

journal_title：Infection and immunity

authors： Karadottir H,Coorens M,Liu Z,Wang Y,Agerberth B,Giske CG,Bergman P

更新日期：2019-12-17 00:00:00

abstract：:Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasi...

journal_title：Infection and immunity

authors： Sultan AS,Rizk AM,Vila T,Ji Y,Masri R,Jabra-Rizk MA

更新日期：2019-11-18 00:00:00

abstract：:Lipopolysaccharides (LPSs) of Gram-negative bacteria comprise lipid A, core, and O-polysaccharide (OPS) components. Studies have demonstrated that LPSs isolated from the pathogenic species Burkholderia pseudomallei and Burkholderia mallei and from less-pathogenic species, such as Burkholderia thailandensis, are potent...

journal_title：Infection and immunity

authors： Sengyee S,Yoon SH,West TE,Ernst RK,Chantratita N

更新日期：2019-11-18 00:00:00

abstract：:Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...

journal_title：Infection and immunity

authors： Rajamanickam A,Munisankar S,Dolla C,Nutman TB,Babu S

更新日期：2019-11-18 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn's disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies are limited. Here we demonstrate that colitis-susceptible Il10-deficient mice dev...

journal_title：Infection and immunity

authors： Ellermann M,Gharaibeh RZ,Fulbright L,Dogan B,Moore LN,Broberg CA,Lopez LR,Rothemich AM,Herzog JW,Rogala A,Gordon IO,Rieder F,Brouwer CR,Simpson KW,Jobin C,Sartor RB,Arthur JC

更新日期：2019-10-18 00:00:00

abstract：:Cutaneous leishmaniasis is characterized by vascular remodeling. Following infection with Leishmania parasites, the vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway mediates lymphangiogenesis, which is critical for lesion resolution. Therefore, we investigated the cellular and ...

journal_title：Infection and immunity

authors： Weinkopff T,Roys H,Bowlin A,Scott P

更新日期：2019-10-18 00:00:00

abstract：:Intracellular bacterial infections affect all vertebrates. Cultured fish are particularly vulnerable because no effective protection measures have been established since such infections emerged approximately 50 years ago. As in other vertebrates, the induction of cell-mediated immunity (CMI) plays an important role in...

journal_title：Infection and immunity

authors： Matsumoto M,Kubota T,Fujita S,Shiozaki K,Kishida S,Yamamoto A

更新日期：2019-10-18 00:00:00

abstract：:It was previously determined that the type II secretion system (T2SS) promotes the ability of Legionella pneumophila to grow in coculture with amoebae. Here, we discerned the stage of intracellular infection that is potentiated by comparing the wild-type and T2SS mutant legionellae for their capacity to parasitize Aca...

journal_title：Infection and immunity

authors： White RC,Truchan HK,Zheng H,Tyson JY,Cianciotto NP

更新日期：2019-10-18 00:00:00

abstract：:Macrophages are critical mediators of innate immunity and must be overcome for bacterial pathogens to cause disease. The Gram-positive bacterium Staphylococcus aureus produces virulence factors that impede macrophages and other immune cells. We previously determined that production of the metabolic cofactor lipoic aci...

journal_title：Infection and immunity

authors： Grayczyk JP,Alonzo F 3rd

更新日期：2019-09-19 00:00:00

abstract：:In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (χ10069) engineered with ΔyopK ΔyopJ Δasd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopENt138-LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae....

journal_title：Infection and immunity

authors： Singh AK,Curtiss R 3rd,Sun W

更新日期：2019-09-19 00:00:00

abstract：:Mycoplasma gallisepticum is an avian respiratory and reproductive tract pathogen that has a significant economic impact on the poultry industry worldwide. Although membrane proteins of Mycoplasma spp. are thought to play crucial roles in host interactions, very few have had their biochemical function defined. In this ...

journal_title：Infection and immunity

authors： Yu Y,Zhang L,Chen Y,Li Y,Wang Z,Li G,Wang G,Xin J

更新日期：2019-08-21 00:00:00

abstract：:Streptococcus suis is one of the most important pathogens affecting the swine industry and is also an emerging zoonotic agent for humans. Two-component signaling systems (TCSs) play important roles in the adaptation of pathogenic bacteria to host environments. In this study, we identified a novel TCS, named TCS09HKRR,...

journal_title：Infection and immunity

authors： Zhong X,Zhang Y,Zhu Y,Dong W,Ma J,Pan Z,Yao H

更新日期：2019-08-21 00:00:00