Abstract:
:Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a correlation with isolate pathogenicity. To investigate the role the capsule plays in G. parasuis virulence and host interaction, a capsule mutant of the serovar 5 strain HS069 was generated (HS069Δcap) through allelic exchange following natural transformation. HS069Δcap was unable to cause signs of systemic disease during a pig challenge study and had increased sensitivity to complement killing and phagocytosis by alveolar macrophages. Compared with the parent strain, HS069Δcap produced more robust biofilm and adhered equivalently to 3D4/31 cells; however, it was unable to persistently colonize the nasal cavity of inoculated pigs, with all pigs clearing HS069Δcap by 5 days postchallenge. Our results indicate the importance of the capsular polysaccharide to G. parasuis virulence as well as nasal colonization in pigs.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Eberle KC,Hau SJ,Luan SL,Weinert LA,Stasko JA,Wang J,Peters SE,Langford PR,Rycroft AN,Wren BW,Maskell DJ,Tucker AW,Brockmeier SLdoi
10.1128/IAI.00879-19subject
Has Abstractpub_date
2020-04-20 00:00:00issue
5eissn
0019-9567issn
1098-5522pii
IAI.00879-19journal_volume
88pub_type
杂志文章abstract::Salmonella enterica serovar Enteritidis is a major cause of food-borne diseases associated with consumption of shell eggs. Clinical isolates of S. enterica serovar Enteritidis exhibit a wide spectrum of virulence in mice. A highly virulent isolate (SE2472) was previously shown to be more resistant in vitro than other ...
journal_title:Infection and immunity
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doi:10.1128/iai.70.2.451-461.2002
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journal_title:Infection and immunity
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doi:10.1128/IAI.40.1.46-55.1983
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.64.7.2839-2841.1996
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journal_title:Infection and immunity
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doi:10.1128/IAI.73.2.972-980.2005
更新日期:2005-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.1.1-6.1984
更新日期:1984-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3490-3495.1993
更新日期:1993-08-01 00:00:00
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更新日期:2012-06-01 00:00:00
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更新日期:2021-01-19 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.12.1.76-80.1975
更新日期:1975-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1996-10-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1996-08-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1996-06-01 00:00:00
abstract::Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma m...
journal_title:Infection and immunity
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更新日期:1999-02-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.56.4.751-755.1988
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.4.1608-1610.1995
更新日期:1995-04-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/iai.68.11.6311-6320.2000
更新日期:2000-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.8.2586-2587.1989
更新日期:1989-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1380-1382.1983
更新日期:1983-09-01 00:00:00
abstract::Bacteroides fragilis with enterotoxin-like activity (BFEL) was isolated from the feces of 24- to 48-h-old lambs with acute diarrheal disease on three different sheep ranches in the Northern Rocky Mountain region of the United States. The lamb intestinal loop test was used to enrich for the bacterium before its initial...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.241-244.1984
更新日期:1984-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00