Abstract:
:Children are more resistant to gingivitis than are adults. To determine possible differences in their periodontal floras, an experimental gingivitis study, identical in design to one reported earlier with young adults, was conducted with four 4- to 6-year-old children. The incidence of sites that developed gingival index scores of 2 in children was less than one-third of the incidence observed in adults. The composition of the flora of each child was statistically significantly different from that of any other child or adult. The floras of the children as a group were statistically significantly different from those of the adults. Children had 3-fold greater proportions of Leptotrichia species, 2.5-fold greater proportions of Capnocytophaga species, 2.3-fold greater proportions of Selenomonas species, 2-fold greater proportions of bacterial species that require formate and fumarate, and 1.5-fold greater proportions of Bacteroides species. Adults had greater proportions of Fusobacterium, Eubacterium, and Lactobacillus species. Fusobacterium nucleatum, Actinomyces WVa 963, Selenomonas D04, and Treponema socranskii were predominant species that correlated with increasing gingival index scores in both children and adults.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Moore WE,Holdeman LV,Smibert RM,Cato EP,Burmeister JA,Palcanis KG,Ranney RRdoi
10.1128/IAI.46.1.1-6.1984subject
Has Abstractpub_date
1984-10-01 00:00:00pages
1-6issue
1eissn
0019-9567issn
1098-5522journal_volume
46pub_type
杂志文章abstract::We have isolated full-length cDNAs encoding two distinct types of CuZn superoxide dismutases (SODs) from the filarial nematode parasite Brugia pahangi. The derived amino acid sequences suggested that one class of cDNAs represented a cytoplasmic form of SOD and the second class represented an extracellular (EC) variant...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.3.961-967.1994
更新日期:1994-03-01 00:00:00
abstract::Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce different disease manifestations in infected mice. Whereas serotype B causes more severe arthritis and reaches higher densities in the blood of mice than serotype A, serotype A invades the central nervous system earlier than serotype B duri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4637-4645.1999
更新日期:1999-09-01 00:00:00
abstract::A Clostridium difficile isolate was found to produce an actin-specific ADP-ribosyltransferase (CDT) homologous to the enzymatic components of Clostridium perfringens iota toxin and Clostridium spiroforme toxin (M. R. Popoff, E. J. Rubin, D. M. Gill, and P. Boquet, Infect. Immun. 56:2299-2306, 1988). The CDT locus from...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.4.1402-1407.1997
更新日期:1997-04-01 00:00:00
abstract::The results of this study show that recombinant interleukin-8 (IL-8) enhances the intracellular killing of Mycobacterium fortuitum by human granulocytes. This chemokine did not stimulate the phagocytosis of M. fortuitum by granulocytes at various bacterium-to-cell ratios. The killing process was not affected by the NA...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3111-3116.1993
更新日期:1993-08-01 00:00:00
abstract::Detailed structural studies were undertaken on five isolates of bovine rotavirus which showed variability in the migration patterns of their genome segments on electrophoresis in polyacrylamide gels. The individual genome segments of each isolate were characterized by partial digestion of terminally radiolabeled RNA w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.2.492-497.1982
更新日期:1982-05-01 00:00:00
abstract::Kinetic, microscopic, and biochemical studies show that virulent Ti (tumor inducing)-plasmid-containing strains of Agrobacterium attach to normal tobacco and carrot tissue culture cells. Kinetic studies showed that virulent strains of A. tumefaciens attach to the plant tissue culture cells in increasing numbers during...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.2.516-522.1978
更新日期:1978-11-01 00:00:00
abstract::While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.5204-5207.2005
更新日期:2005-08-01 00:00:00
abstract::Saccharomyces boulardii is a nonpathogenic yeast used in the treatment of Clostridium difficile diarrhea and colitis. We have reported that S. boulardii inhibits C. difficile toxin A enteritis in rats by releasing a 54-kDa protease which digests the toxin A molecule and its brush border membrane (BBM) receptor (I. Cas...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.1.302-307.1999
更新日期:1999-01-01 00:00:00
abstract::The P2 porin protein is the most abundant protein in the outer membrane of Haemophilus influenzae type b (Hib). Biochemical and immunochemical techniques were used to characterize the P2 proteins from a number of different Hib strains. P2 proteins from Hib outer membrane vesicles were resolved by sodium dodecyl sulfat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.11.3270-3275.1989
更新日期:1989-11-01 00:00:00
abstract::Splenic lymphocytes from cytomegalovirus-infected mice lost their in vitro proliferative responses to cytomegalovirus antigen within 3 h after in vivo treatment with antilymphocyte globulin and prednisolone. The response was inhibited when the agents were administered separately or together, and inhibition persisted t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Burkholderia pseudomallei is a facultative intracellular gram-negative bacterium that can survive and multiply inside macrophages. One of the mechanisms by which B. pseudomallei escapes macrophage killing is by interfering with the expression of inducible nitric oxide synthase (iNOS). However, the bacterial components...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00285-07
更新日期:2007-09-01 00:00:00
abstract::Host resistance to African trypanosomiasis is partially dependent on an early and strong T-independent B-cell response against the variant surface glycoprotein (VSG) coat expressed by trypanosomes. The repetitive array of surface epitopes displayed by a monotypic surface coat, in which identical VSG molecules are clos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2690-2697.2005
更新日期:2005-05-01 00:00:00
abstract::The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.284-285.1974
更新日期:1974-07-01 00:00:00
abstract::Human gingival fibroblasts were exposed in culture to cell extracts of different black-pigmented Bacteroides species, and their growth was monitored by determining thymidine uptake and counting cells. Of the Bacteroides species tested (B. gingivalis, B. asaccharolyticus, and B. intermedius), B. gingivalis gave the ext...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.1.201-205.1987
更新日期:1987-01-01 00:00:00
abstract::Monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans produce distinct capsular reactions and have biological activities that are determined by serotype specificity. In the present study, polyclonal rabbit anticapsular antibodies were cross-absorbed to produce serotype specificities similar t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.2.1189-1191.2001
更新日期:2001-02-01 00:00:00
abstract::The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.6058-6062.2003
更新日期:2003-10-01 00:00:00
abstract::Bacillus anthracis is surrounded by a polypeptide capsule composed of poly-gamma-d-glutamic acid (gammaDPGA). In a previous study, we reported that a monoclonal antibody (MAb F26G3) reactive with the capsular polypeptide is protective in a murine model of pulmonary anthrax. The present study examined a library of six ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01133-06
更新日期:2007-01-01 00:00:00
abstract::Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and inf...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05806-11
更新日期:2011-12-01 00:00:00
abstract::Three dominant proteins (41, 48, and 49 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in purified preparations of the extracellular aspartyl proteinase (AP) of Candida albicans. All three proteins bound to the specific carboxyl proteinase ligand, pepstatin A, and were assoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.5.2030-2036.1993
更新日期:1993-05-01 00:00:00
abstract::The cytotoxic effects of bacterial lipopolysaccharides (LPS) on mouse leukocytes have been examined in vivo and in vitro. Intraperitoneal injection of LPS into C57BL/6 mice greatly reduced the recovery of mononuclear cells; LPS was cytotoxic for macrophages, but had a mitogenic effect on lymphocytes. Similar effects o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.1.310-319.1978
更新日期:1978-07-01 00:00:00
abstract::In meningococcal septic shock, the dominant inducer of inflammation is lipopolysaccharide (LPS) in the outer membrane of Neisseria meningitidis, while interleukin-10 (IL-10) is the principal anti-inflammatory cytokine. We have used microarrays and Ingenuity Pathway Analysis to study the global effects of IL-10 on gene...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00386-12
更新日期:2012-11-01 00:00:00
abstract::We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00901-13
更新日期:2014-05-01 00:00:00
abstract::The dermotropism of Cryptococcus neoformans SLHA in congenitally athymic (nu/nu) and doubly immunodeficient beige-athymic (bg/bg-nu/nu) mice is described. Both bg/bg-nu/nu and nu/nu mice developed cutaneous cryptococcosis within 7 to 12 days following intravenous challenge with 10(4) encapsulated yeast cells. Macrosco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.5.1785-1789.1991
更新日期:1991-05-01 00:00:00
abstract::Knowledge of the in vivo physiology and metabolism of Streptococcus pneumoniae is limited, even though pneumococci rely on efficient acquisition and metabolism of the host nutrients for growth and survival. Because the nutrient-limited, hypoxic host tissues favor mixed-acid fermentation, we studied the role of the pne...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00178-09
更新日期:2009-12-01 00:00:00
abstract::The complement system plays a key role in resistance to cryptococcosis. In the present study, we examined several factors that influence the binding of C3 cleavage fragments to Cryptococcus neoformans. Binding of C3 was determined by using normal human serum supplemented with 125I-labeled C3. Incubation of encapsulate...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.1.1-5.1986
更新日期:1986-04-01 00:00:00
abstract::The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also influence activation of the MyD88-dependent and -independent signaling pathways of TLR4. To address this possibility, human...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2940-2950.2005
更新日期:2005-05-01 00:00:00
abstract::The actions of polymyxin B, rabbit polymorphonuclear lysosome extracts, 14 polycationic peptides (including defensin NP-2, cecropin P1, lactoferricin B, and active peptides from cationic protein 18 and bactenecin), EDTA, and Tris on Brucella spp. were studied, with other gram-negative bacteria as controls. Brucella sp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.3054-3061.1995
更新日期:1995-08-01 00:00:00
abstract::We utilized magnetic resonance imaging to visualize lesions in the lungs of guinea pigs infected by low-dose aerosol exposure to Mycobacterium tuberculosis. Lesions were prominent in such images, and colorized three-dimensional reconstructions of images revealed a very uniform distribution in the lungs. Lesion numbers...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5963-5971.2004
更新日期:2004-10-01 00:00:00
abstract::A T antigen preparation free of trypsin was obtained by application of CNBr-Sepharose linked to pure trypsin. Purification on an ion exchange chromatography column results in an electrophoretically homogeneous preparation of T protein. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.993-994.1976
更新日期:1976-03-01 00:00:00
abstract::A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.8.4183-4190.1999
更新日期:1999-08-01 00:00:00