Abstract:
:The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Kleinschmidt WJ,Van Etten JL,Vidaver AKdoi
10.1128/IAI.10.1.284-285.1974subject
Has Abstractpub_date
1974-07-01 00:00:00pages
284-5issue
1eissn
0019-9567issn
1098-5522journal_volume
10pub_type
杂志文章abstract::In this analysis we have examined in detail the effects of low concentrations of zinc on the growth and dimorphism of Candida albicans. Evidence is presented that micromolar concentrations of zinc added to growth cultures grown at 25 degrees C (i) cause a twofold increase in the final concentration of spheres at satio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.348-354.1979
更新日期:1979-10-01 00:00:00
abstract::Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study this, sera were obtained from five pediatric patients with acute diarrhe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.9.5090-5095.2000
更新日期:2000-09-01 00:00:00
abstract::The purpose of the present study was to analyze Chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. Peripheral blood mononuclear cells of four persons infected with C. pneumoniae Kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of C. pneumoniae Ka...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.5.2196-2199.1993
更新日期:1993-05-01 00:00:00
abstract::Ocular toxoplasmosis is a potentially blinding intraocular inflammation. The intent of this study was to investigate the role of Fas-FasL interaction in a murine model of acquired ocular toxoplasmosis induced by intracameral inoculation of Toxoplasma gondii. Intraocular inflammation, Fas and FasL expression on lymphoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.928-935.1999
更新日期:1999-02-01 00:00:00
abstract::Complement-containing immune complexes can be presented to phagocytes by human erythrocytes bearing complement receptor 1 (CR1). Although this has long been assumed to be a mechanism by which humans are able to protect themselves from "extracellular" bacteria such as pneumococci, there is little direct evidence. In th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01263-09
更新日期:2010-07-01 00:00:00
abstract::The toxicity by inhalation of various gram-negative bacteria, isolated from settings associated with inhalation disease, was studied by a variety of means. These microorganisms were not equally toxic. Citrobacter freundii aerosol challenges of rabbits provoked significant (up to fivefold) increases in plasma haptoglob...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.1.133-138.1983
更新日期:1983-04-01 00:00:00
abstract::Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.598-603.1983
更新日期:1983-08-01 00:00:00
abstract::Intestinal epithelial cells (IECs), including secretory goblet cells, form essential physiochemical barriers that separate luminal bacteria from underlying immune cells in the intestinal mucosa. IECs are common targets for enteric bacterial pathogens, with hosts responding to these microbes through innate toll-like re...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02045-14
更新日期:2014-09-01 00:00:00
abstract::A family of high-molecular-weight (HMW) surface-exposed proteins important in the attachment of nontypeable Haemophilus influenzae (NTHi) to human epithelial cells was previously identified (J. W. St. Geme III, S. Falkow, and S. J. Barenkamp, Proc. Natl. Acad. Sci. USA 90:2875-2879, 1993). In the present investigation...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.10.4460-4468.1994
更新日期:1994-10-01 00:00:00
abstract::By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.1.292-300.1982
更新日期:1982-07-01 00:00:00
abstract::Toxin A (TcdA) and toxin B (TcdB) are major virulence factors of Clostridium difficile. These two toxins intoxicate cultured cells by similar mechanisms, and TcdB generally is more potent than TcdA in cultured cells. The exact reason for this difference is unclear. Here, we report that the cellular effects of TcdA can...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01577-08
更新日期:2009-06-01 00:00:00
abstract::Toxin preparations were obtained by growing Clostridium difficile VPI strain 10463 in 2-liter brain heart infusion dialysis flasks at 37 degrees C for 3 days. The initial step of the purification scheme involved ultrafiltration through an XM-100 membrane filter. Two toxic activities, designated toxins A and B, were se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.1032-1040.1982
更新日期:1982-03-01 00:00:00
abstract::Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.10.6119-6122.2001
更新日期:2001-10-01 00:00:00
abstract::Surface layer proteins (SLPs) are essential for induction of abortion by Campylobacter fetus subsp. fetus in experimentally challenged ewes. These proteins are encoded by multiple sap genes and vary in size and antigenicity. The role of SLP antigenic variation during experimental ovine infection was investigated. Foll...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.1.147-154.2003
更新日期:2003-01-01 00:00:00
abstract::Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P. aeruginosa expresses multiple iron uptake systems, whose role in lung infection deserves further investigation. P. aeruginosa Fe(3+) uptake sy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00098-16
更新日期:2016-07-21 00:00:00
abstract::Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.2.1174-1180.2004
更新日期:2004-02-01 00:00:00
abstract::The compositions of lipopolysaccharides I and II, isolated from Coxiella burnetii phase I and pure phase II cells, respectively, showed drastic and clear-cut differences. Lipopolysaccharide II exhibited a comparatively simple composition. It contained, in addition to glucosamine (from lipid A) and a 2-keto-3-deoxyoctu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.53-57.1982
更新日期:1982-10-01 00:00:00
abstract::Histophilus somni is capable of intracellular survival within professional phagocytic cells, but the mechanism of survival is not understood. The Fic motif within the direct repeat (DR1)/DR2 domains of the IbpA fibrillary network protein of H. somni is cytotoxic to epithelial and phagocytic cells, which may interfere ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00365-18
更新日期:2018-11-20 00:00:00
abstract::Escherichia coli D2 (serotype 07:H-) that was isolated from a child with diarrhea hybridized with an F1845 DNA probe used to detect diffuse adherence. Strain D2 adhered to tissue culture cells (HeLa and HEp-2 cells) in a clustered pattern but did not autoagglutinate on the cell surface and induced the elongation of mi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.7.2917-2929.1994
更新日期:1994-07-01 00:00:00
abstract::Infectious agents are often considered potential triggers of chronic inflammatory disease, including autoimmunity; however, direct evidence is usually lacking. Here we show that following control of acute infection of mice with the myotropic Colombiana strain of Trypanosoma cruzi, parasites persisted in tissue at low ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01497-15
更新日期:2016-03-24 00:00:00
abstract::The level of type-specific antigen (that covalently associated with the cell wall peptidoglycan and that released extracellularly) synthesized by virulent and avirulent strains of type III group B streptococci was quantitated and compared. Additionally, the effect of the physiological age of the cells and the influenc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.217-221.1984
更新日期:1984-05-01 00:00:00
abstract::Iron starvation conditions limited the growth of Salmonella typhi, as evidenced by an increase in the lag phase of a culture and a decrease in the number of bacteria reached in the stationary phase. The analysis of the outer membrane of bacteria grown under these conditions identified new protein components with appar...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.4.1271-1275.1989
更新日期:1989-04-01 00:00:00
abstract::Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for fu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01783-05
更新日期:2006-07-01 00:00:00
abstract::We wished to find a simple, biologically relevant method to evaluate the virulence of dengue viruses for human beings. Since cells of mononuclear phagocyte lineage may be important sites of dengue infection in primates, we evaluated the permissiveness of these cells to dengue virus as a correlate of virus virulence. T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.102-106.1981
更新日期:1981-01-01 00:00:00
abstract::Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.6.3551-3562.2003
更新日期:2003-06-01 00:00:00
abstract::Vibrio cholerae is a monoflagellated gram-negative bacterium that causes the severe diarrheal disease cholera. In contrast to Salmonella enterica serovar Typhimurium infection, which is accompanied by both acute diarrhea and high-level inflammation, V. cholerae infection is largely noninflammatory in human hosts. Bact...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00736-07
更新日期:2008-03-01 00:00:00
abstract::To explore the molecular basis of the T-cell-mediated immune response to Listeria monocytogenes, we cloned and expressed listerial antigens in Escherichia coli using the lambda-ZAP bacteriophage and Bluescript plasmid vectors. A two-stage screening strategy was implemented to identify T-cell-reactive antigens; the fir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2792-2803.1990
更新日期:1990-09-01 00:00:00
abstract::In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6648-6652.2003
更新日期:2003-11-01 00:00:00
abstract::A protein factor which induces high levels of gamma interferon (IFN-gamma) in resting splenic nonadherent cells was isolated from the sera of mice with generalized inflammation caused by endotoxic shock. The factor was highly purified by ammonium sulfate precipitation followed by ion-exchange column chromatography on ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.1.64-70.1993
更新日期:1993-01-01 00:00:00
abstract::Streptolysin-O (SLO) is a thiol-activated, membrane-damaging protein toxin of Mr 69,000 that is produced by most strains of beta-hemolytic group A streptococci. Native, primarily water-soluble toxin molecules bind to cholesterol-containing target membranes to assemble into supramolecular curved rod structures (25 to 1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.52-60.1985
更新日期:1985-01-01 00:00:00