Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A.

abstract：:The relationship between hypersensitivity and cellular resistance to infection with facultative intracellular parasites was studied in mice by using infection-immunity in tularemia as a model system. Delayed hypersensitivity to antigenic fractions of Francisella tularensis was first detected 6 to 7 days after immuniza...

journal_title：Infection and immunity

authors： Claflin JL,Larson CL

更新日期：1972-03-01 00:00:00

abstract：:In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor...

journal_title：Infection and immunity

authors： Delfino D,Cianci L,Lupis E,Celeste A,Petrelli ML,Curró F,Cusumano V,Teti G

更新日期：1997-06-01 00:00:00

abstract：:High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of genes in hosts infected in vivo, which result in radically different clinical outcomes. We present an analysis of the g...

journal_title：Infection and immunity

authors： Schaecher K,Kumar S,Yadava A,Vahey M,Ockenhouse CF

更新日期：2005-09-01 00:00:00

abstract：:A study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid, the falloff in antitoxin appears to be fractionally constant for each individual, and over periods of 5 to 6 yea...

journal_title：Infection and immunity

authors： Trinca JC

更新日期：1974-07-01 00:00:00

abstract：:Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasi...

journal_title：Infection and immunity

authors： Sultan AS,Rizk AM,Vila T,Ji Y,Masri R,Jabra-Rizk MA

更新日期：2019-11-18 00:00:00

abstract：:Four strains of Staphylococcus aureus of a phage type other than the second group, isolated from patients with impetigo and Ritter's disease, were found to produce an exotoxin similar to those reported by Melish et al. (1972), Kapral and Miller (1971), and Arbuthnott et al. (1973). This toxin could elicit a general ex...

journal_title：Infection and immunity

authors： Kondo I,Sakurai S,Sarai Y

更新日期：1974-10-01 00:00:00

abstract：:Heart and muscle tissues appear to be specific target organs for the in vivo inhibition of protein synthesis by diphtheria toxin. ...

journal_title：Infection and immunity

authors： Bowman CG,Imhoff JG,Bonventre PF

更新日期：1970-11-01 00:00:00

abstract：:Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria, occurring in many, but not all, genera in the Alphaproteobacteria, Betaprote...

journal_title：Infection and immunity

authors： Cianciotto NP,White RC

更新日期：2017-04-21 00:00:00

abstract：:The viaB locus coding for the Vi antigen of Salmonella typhi Ty2 was cloned on a 40.6-kilobase fragment into the cosmid vector pHC79. The live, oral, attenuated Vi-negative S. typhi Ty21a vaccine strain was transformed with the recombinant cosmid encoding the viaB locus. Homologous recombination of the viaB locus into...

journal_title：Infection and immunity

authors： Cryz SJ Jr,Fürer E,Baron LS,Noon KF,Rubin FA,Kopecko DJ

更新日期：1989-12-01 00:00:00

abstract：:Salmonellae possess the ability to adhere to and invade macrophages and in so doing trigger a number of intracellular events that are associated with cellular activation. As an initial approach to defining the mechanisms by which invasive salmonellae alter macrophage function, we have explored the impact of Salmonella...

journal_title：Infection and immunity

authors： Mizel SB,Kucera LS,Richardson SH,Ciacci F,Iyer NP

更新日期：1995-05-01 00:00:00

abstract：:In Shigella flexneri a 220-kilobase plasmid encodes the ability to invade nonprofessional phagocytes by a mechanism similar to phagocytosis. In this report, the continuous macrophage cell line J774 was used to study the intracellular fate of both invasive and noninvasive strains. pWR100, the virulence plasmid of S. fl...

journal_title：Infection and immunity

authors： Clerc PL,Ryter A,Mounier J,Sansonetti PJ

更新日期：1987-03-01 00:00:00

abstract：:In this report, we demonstrate that the variable antigens present on the surface of Plasmodium knowlesi-infected erythrocytes could not be found on the surface of merozoites. A number of technical problems had to be solved to make such a comparative study possible, including the purification of merozoites by affinity ...

journal_title：Infection and immunity

authors： Hommel M,David PH

更新日期：1981-07-01 00:00:00

abstract：:Cord factor (trehalose 6,6'-dimycolate[TDM] ), a mixture of 6,6'-diesters of alpha, alpha-D-trehalose with natural mycolic acids, has been described as having immunoregulatory and antitumor activities in vivo, although the relevant mechanisms of action remain unelucidated. In this work, we measured the effects of TDM ...

journal_title：Infection and immunity

authors： Kierszenbaum F,Zenian A,Wirth JJ

更新日期：1984-02-01 00:00:00

abstract：:The ability of Streptococcus salivarius strain TOVE-R to inhibit the ecological emergence of virulent representatives of the most prevalent human mutans streptococci on the teeth of specific pathogen-free Osborne-Mendel rats was studied. Rats which were infected by TOVE-R, or either S. mutans 10449S or S. sobrinus 671...

journal_title：Infection and immunity

authors： Tanzer JM,Kurasz AB,Clive J

更新日期：1985-07-01 00:00:00

abstract：:Lipopolysaccharides (LPS), either in the free form or complexed to CD14, a LPS receptor, are elicitors of the immune system. Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock. Since optimal protection requires administration of Lf prior to lethal doses of LPS, we hypothesized that i...

journal_title：Infection and immunity

authors： Baveye S,Elass E,Fernig DG,Blanquart C,Mazurier J,Legrand D

更新日期：2000-12-01 00:00:00

abstract：:Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a small, cationic peptide generated from rabbit platelets when they are exposed to thrombin in vitro. It has potent microbicidal activity against a broad spectrum of bacterial and fungal pathogens, including Staphylococcus aureus. Previous in vitro studies i...

journal_title：Infection and immunity

authors： Koo SP,Bayer AS,Kagan BL,Yeaman MR

更新日期：1999-05-01 00:00:00

abstract：:Conditions are described for the production of an extracellular cytotoxin or CHO cell-killing factor by Vibrio fluvialis, a recently recognized enteric pathogen. The cell-killing factor was ammonium sulfate precipitable, heat labile, and inactivated by proteases, and had an isoelectric point (estimated by sucrose dens...

journal_title：Infection and immunity

authors： Wall VW,Kreger AS,Richardson SH

更新日期：1984-12-01 00:00:00

abstract：:Legionella pneumophila, the gram-negative agent of Legionnaires' disease, possesses type IV pili and a type II protein secretion (Lsp) system, both of which are dependent upon the PilD prepilin peptidase. By analyzing multiple pilD mutants and various types of Lsp mutants as well as performing trans-complementation of...

journal_title：Infection and immunity

authors： Rossier O,Starkenburg SR,Cianciotto NP

更新日期：2004-01-01 00:00:00

abstract：:Local gingival immunization was attempted in an effort to confine the immune response to the oral cavity and bypass the systemic immune response. A low-molecular-weight (3.8K) streptococcal antigen (SA) I/II was applied 10 times over a period of 1 year to the gingival crevices of rhesus monkeys. The antigen was mainta...

journal_title：Infection and immunity

authors： Lehner T,Mehlert A,Caldwell J

更新日期：1986-06-01 00:00:00

abstract：:It is currently accepted that malaria-parasitized red blood cells (pRBC) are eliminated, like senescent erythrocytes, phagocytically by macrophages in the red pulp of the spleen. Here, however, we show that self-healing Plasmodium chabaudi malaria activates spleen closure in C57BL/6 mice. Confocal laser scanning micro...

journal_title：Infection and immunity

authors： Krücken J,Mehnert LI,Dkhil MA,El-Khadragy M,Benten WP,Mossmann H,Wunderlich F

更新日期：2005-10-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Lipopolysaccharides (LPSs) of Gram-negative bacteria comprise lipid A, core, and O-polysaccharide (OPS) components. Studies have demonstrated that LPSs isolated from the pathogenic species Burkholderia pseudomallei and Burkholderia mallei and from less-pathogenic species, such as Burkholderia thailandensis, are potent...

journal_title：Infection and immunity

authors： Sengyee S,Yoon SH,West TE,Ernst RK,Chantratita N

更新日期：2019-11-18 00:00:00

abstract：:Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...

journal_title：Infection and immunity

authors： Casselli T,Lynch T,Southward CM,Jones BW,DeVinney R

更新日期：2008-05-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:Development of an effective vaccine against Leishmania infection is a priority of tropical disease research. We have recently demonstrated protection against Leishmania major in the murine and nonhuman primate models with individual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA ...

journal_title：Infection and immunity

authors： Coler RN,Skeiky YA,Bernards K,Greeson K,Carter D,Cornellison CD,Modabber F,Campos-Neto A,Reed SG

更新日期：2002-08-01 00:00:00

abstract：:Variation has been observed in the structural polypeptides of swine vesicular disease viruses isolated from the United Kingdom and Hong Kong. Despite the limited number of isolates examined, several distinct polypeptide patterns were obtained when the virus structural proteins were examined by polyacrylamide gel elect...

journal_title：Infection and immunity

authors： Harris TJ,Underwood BO,Knowles NJ,Crowther JR,Brown F

更新日期：1979-06-01 00:00:00

abstract：:A gene encoding a heat-stable enterotoxin (ST) from an Escherichia coli strain isolated from a human with diarrhea was cloned and characterized by nucleotide sequence analysis. The gene was found to be partially homologous to a previously characterized ST gene from an E. coli strain of bovine origin. Hybridization stu...

journal_title：Infection and immunity

authors： Moseley SL,Hardy JW,Hug MI,Echeverria P,Falkow S

更新日期：1983-03-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:The role of CD4+ and CD8+ T cells in the response to intranasal infection with a Mycobacterium avium complex isolate (MAC) was investigated. Depletion of CD4+ T cells by injected antibody exacerbated infection in the lung, spleen, and liver. There were decreased numbers of inflammatory cells in the lungs of CD4-deplet...

journal_title：Infection and immunity

authors： Saunders BM,Cheers C

更新日期：1995-06-01 00:00:00

abstract：:It was shown that a strain of Serratia liquefaciens harbors a conjugative R-plasmid responsible for reistance to the following 14 antibiotics: ampicillin, carbenicillin, cephalothin, butirosin, neomycin, paramomycin, kanamycin, lividomycin, gentamicin, tobramycin, streptomycin, tetracycline, sulfonamide, and chloramph...

journal_title：Infection and immunity

authors： Duval-Iflah Y,Raibaud P,Tancrede C,Rousseau M

更新日期：1980-06-01 00:00:00