Molecular approach to the epidemiology of swine vesicular disease: correlation of variation in the virus structural polypeptides with serological properties.

abstract：:The tetraspanins are a superfamily of transmembrane proteins with diverse functions and can form extended microdomains within the plasma membrane in conjunction with partner proteins, which probably includes receptors for bacterial adhesins. Neisseria meningitidis, the causative agent of meningococcal disease, attache...

journal_title：Infection and immunity

authors： Green LR,Monk PN,Partridge LJ,Morris P,Gorringe AR,Read RC

更新日期：2011-06-01 00:00:00

abstract：:A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels o...

journal_title：Infection and immunity

authors： Adam C,Géniteau M,Gougerot-Pocidalo M,Verroust P,Lebras J,Gibert C,Morel-Maroger L

更新日期：1981-02-01 00:00:00

abstract：:Diarrhea and amebic liver abscesses due to invasive Entamoeba histolytica infections are an important cause of morbidity and mortality in the developing world. Entamoeba histolytica adherence and cell migration, two phenotypes linked to virulence, are both aberrant in trophozoites deficient in the metallosurface prote...

journal_title：Infection and immunity

authors： Roncolato EC,Teixeira JE,Barbosa JE,Zambelli Ramalho LN,Huston CD

更新日期：2015-02-01 00:00:00

abstract：:Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. bau...

journal_title：Infection and immunity

authors： Russo TA,Luke NR,Beanan JM,Olson R,Sauberan SL,MacDonald U,Schultz LW,Umland TC,Campagnari AA

更新日期：2010-09-01 00:00:00

abstract：:The P2 porin protein is the most abundant protein in the outer membrane of Haemophilus influenzae type b (Hib). Biochemical and immunochemical techniques were used to characterize the P2 proteins from a number of different Hib strains. P2 proteins from Hib outer membrane vesicles were resolved by sodium dodecyl sulfat...

journal_title：Infection and immunity

authors： Hansen EJ,Pelzel SE,Orth K,Moomaw CR,Radolf JD,Slaughter CA

更新日期：1989-11-01 00:00:00

abstract：:Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained m...

journal_title：Infection and immunity

authors： North RJ,LaCourse R,Ryan L

更新日期：1999-04-01 00:00:00

abstract：:The effect of iron concentration during growth on the physicochemical surface properties of the colonial variants of Neisseria gonorrhoeae has been assessed by aqueous two-phase partitioning in a dextran-polyethyleneglycol system containing positively charged trimethylamino-polyethyleneglycol or hydrophobic polyethyle...

journal_title：Infection and immunity

authors： Magnusson KE,Kihlstrom E,Norqvist A,Davies J,Normark S

更新日期：1979-11-01 00:00:00

abstract：:Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and to evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract and a tick saliva protein, Salp15, inhibit in vitro keratinocy...

journal_title：Infection and immunity

authors： Marchal C,Schramm F,Kern A,Luft BJ,Yang X,Schuijt TJ,Hovius JW,Jaulhac B,Boulanger N

更新日期：2011-02-01 00:00:00

abstract：:The two-component regulatory system, GraRS, appears to be involved in staphylococcal responses to cationic antimicrobial peptides (CAPs). However, the mechanism(s) by which GraRS is induced, regulated, and modulated remain undefined. In this study, we used two well-characterized MRSA strains (Mu50 and COL) and their r...

journal_title：Infection and immunity

authors： Yang SJ,Bayer AS,Mishra NN,Meehl M,Ledala N,Yeaman MR,Xiong YQ,Cheung AL

更新日期：2012-01-01 00:00:00

abstract：:Escherichia coli heat-stable enterotoxin (ST) appears to cause intestinal fluid secretion by activating intestinal particulate guanylate cyclase. Recent studies suggest that chlorpromazine and quinacrine reduce the intestinal secretory response to ST and activation of guanylate cyclase by ST. We have examined the effe...

journal_title：Infection and immunity

authors： Greenberg RN,Murad F,Guerrant RL

更新日期：1982-02-01 00:00:00

abstract：:Molecular approaches to the rapid analysis of the serotyping antigens of Neisseria meningitidis, the class 2 and 3 outer membrane proteins (OMPs), were developed, evaluated, and used to study 12 antigenic variants of these proteins. A primer set for the polymerase chain reaction (PCR) amplification of the genes encodi...

journal_title：Infection and immunity

authors： Feavers IM,Suker J,McKenna AJ,Heath AB,Maiden MC

更新日期：1992-09-01 00:00:00

abstract：:Helicobacter pylori colonizes the gastric epithelium of at least 50% of the world's human population, playing a causative role in the development of chronic gastritis, peptic ulcers, and gastric adenocarcinoma. Current evidence indicates that H. pylori can invade epithelial cells in the gastric mucosa. However, relati...

journal_title：Infection and immunity

authors： Terebiznik MR,Vazquez CL,Torbicki K,Banks D,Wang T,Hong W,Blanke SR,Colombo MI,Jones NL

更新日期：2006-12-01 00:00:00

abstract：:Previously, we isolated a high-molecular-weight immunogenic polysaccharide (designated PS) from Pseudomonas aeruginosa immunotype 1 (IT-1). The method which we used was modified to permit the isolation of a similar PS from P. aeruginosa IT-2. This antigen was composed primarily of carbohydrate, had a complex monosacch...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Sadoff JC

更新日期：1981-11-01 00:00:00

abstract：:The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin antigen, choleragen, choleragenoid, and Formalin-treated choleragen (formagen). The results indicated that choleragen evoke...

journal_title：Infection and immunity

authors： Finkelstein RA,Hollingsworth RC

更新日期：1970-05-01 00:00:00

abstract：:The microfilament inhibitors cytochalasins B and D have been traditionally used to indirectly evaluate the requirement for actin in the uptake of invasive bacterial pathogens by nonprofessional phagocytes. Through their effects on microfilaments, both cytochalasins also impart profound alterations in cellular morpholo...

journal_title：Infection and immunity

authors： Ewanowich CA,Peppler MS

更新日期：1990-10-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Spleen cell cultures from guinea pigs given legionella pneumophila vaccine in complete Freund adjuvant or as a sublethal infection were inhibited in their migration activity in vitro when incubated with specific antigen. Both direct and indirect migration inhibition assays revealed sensitization of the guinea pigs to ...

journal_title：Infection and immunity

authors： Friedman H,Widen R,Lee I,Klein T

更新日期：1983-09-01 00:00:00

abstract：:The growth of Eimeria vermiformis within cultured murine fibroblastlike (L-929) or rat epithelial-like (RATEC) cells was inhibited by treatment of the cells with the appropriate recombinant gamma interferon. The effect was apparent as a reduction in both the initial numbers of intracellular sporozoites and, to a much ...

journal_title：Infection and immunity

authors： Rose ME,Smith AL,Wakelin D

更新日期：1991-02-01 00:00:00

abstract：:A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was ...

journal_title：Infection and immunity

authors： Andersson B,Eriksson B,Falsen E,Fogh A,Hanson LA,Nylén O,Peterson H,Svanborg Edén C

更新日期：1981-04-01 00:00:00

abstract：:The adhesion of gram-positive bacteria to extracellular matrix (ECM) proteins is regarded as an important determinant of pathogenicity. A comparison of the adhesion of Streptococcus agalactiae strain O90R to different ECM proteins showed that the most pronounced binding could be observed for immobilized fibrinogen. To...

journal_title：Infection and immunity

authors： Spellerberg B,Rozdzinski E,Martin S,Weber-Heynemann J,Lütticken R

更新日期：2002-05-01 00:00:00

abstract：:Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates ...

journal_title：Infection and immunity

authors： Bowden SD,Rowley G,Hinton JC,Thompson A

更新日期：2009-07-01 00:00:00

abstract：:Iron is an important element for the growth of microorganisms as well as in the defense of the host by serving as a catalyst for the generation of free radicals via the Fenton/Haber-Weiss reactions. The iron transporter natural resistance-associated macrophage protein 1 (Nramp1) confers resistance to the growth of a v...

journal_title：Infection and immunity

authors： Zhong W,Lafuse WP,Zwilling BS

更新日期：2001-11-01 00:00:00

abstract：:Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective...

journal_title：Infection and immunity

authors： Liu T,Lu X,Zhao C,Fu X,Zhao T,Xu W

更新日期：2015-05-01 00:00:00

abstract：:Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB ...

journal_title：Infection and immunity

authors： Teichert M,Tatge H,Schoentaube J,Just I,Gerhard R

更新日期：2006-10-01 00:00:00

abstract：:Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...

journal_title：Infection and immunity

authors： Riley SP,Patterson JL,Martinez JJ

更新日期：2012-08-01 00:00:00

abstract：:Although the opportunistic bacterial pathogen Enterococcus faecium is a leading source of nosocomial infections, it appears to lack many of the overt virulence factors produced by other bacterial pathogens, and the underlying mechanism of pathogenesis is not clear. Using E. faecium-mediated killing of the nematode wor...

journal_title：Infection and immunity

authors： Moy TI,Mylonakis E,Calderwood SB,Ausubel FM

更新日期：2004-08-01 00:00:00

abstract：:Insertional inactivation of the Streptococcus mutans spaP gene was used to construct an isogenic mutant (834) of strain NG8 (serotype c) which lacked the major cell surface-associated protein referred to as P1 (15). Results of several studies suggest that P1 is involved in the adherence of S. mutans to saliva-coated a...

journal_title：Infection and immunity

authors： Bowen WH,Schilling K,Giertsen E,Pearson S,Lee SF,Bleiweis A,Beeman D

更新日期：1991-12-01 00:00:00

abstract：:We investigated the mechanisms that lead to the production of proinflammatory mediators by human monocytes when these cells are exposed in vitro to live Borrelia burgdorferi spirochetes. We first focused on myeloid differentiation primary response protein 88 (MyD88), an adapter molecule that is essential in the Toll-l...

journal_title：Infection and immunity

authors： Dennis VA,Dixit S,O'Brien SM,Alvarez X,Pahar B,Philipp MT

更新日期：2009-03-01 00:00:00

abstract：:Capsular glucuronoxylomannans (GXM) of Cryptococcus neoformans var. neoformans isolates from patients with recurrent cryptococcal meningitis were analyzed by 1H nuclear magnetic resonance spectroscopy and for reactivity with factor sera (Iatron, Tokyo, Japan). For each patient the initial and relapse isolates had prev...

journal_title：Infection and immunity

authors： Cherniak R,Morris LC,Belay T,Spitzer ED,Casadevall A

更新日期：1995-05-01 00:00:00

abstract：:We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor [CPAF]). We now report that sera collected from these infected individuals neutralized the proteolytic act...

journal_title：Infection and immunity

authors： Sharma J,Dong F,Pirbhai M,Zhong G

更新日期：2005-07-01 00:00:00