Gamma interferon-mediated inhibition of Eimeria vermiformis growth in cultured fibroblasts and epithelial cells.

abstract：:We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes....

journal_title：Infection and immunity

authors： Handley SA,Newberry RD,Miller VL

更新日期：2005-12-01 00:00:00

abstract：:Following intranasal inoculation, Vibrio cholerae KFV101 (DeltactxAB DeltahapA DeltahlyA DeltartxA) colonizes and stimulates tumor necrosis factor alpha and interleukin 1beta (IL-1beta) in mice, similar to what occurs with isogenic strain P4 (DeltactxAB), but is less virulent and stimulates reduced levels of IL-6, dem...

journal_title：Infection and immunity

authors： Haines GK 3rd,Sayed BA,Rohrer MS,Olivier V,Satchell KJ

更新日期：2005-09-01 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) is a food-borne pathogen with a low infectious dose that colonizes the colon in humans and can cause severe clinical manifestations such as hemolytic-uremic syndrome. The urease enzyme, encoded in the STEC chromosome, has been demonstrated to act as a virulence factor in o...

journal_title：Infection and immunity

authors： Steyert SR,Kaper JB

更新日期：2012-08-01 00:00:00

abstract：:Nitration of protein A with tetranitromethane incompletely blocks its Fc-binding ability for immunoglobulin G when measured by more sensitive methods of immunoprecipitation and when tested in the enzyme-linked immunosorbent assay. In addition, binding of protein A and blockage by nitration is heterogeneous and depends...

journal_title：Infection and immunity

authors： Sloan GJ,Butler JE

更新日期：1978-08-01 00:00:00

abstract：:F344 rats chronically infected with Ureaplasma parvum develop two distinct profiles: asymptomatic urinary tract infection (UTI) and UTI complicated by struvite urolithiasis. To identify factors that affect disease outcome, we characterized the temporal host immune response during infection by histopathologic analysis ...

journal_title：Infection and immunity

authors： Reyes L,Alvarez S,Allam A,Reinhard M,Brown MB

更新日期：2009-10-01 00:00:00

abstract：:The salmonid macrophage-like cell line RTS-11 and purified trout pronephros phagocytes were used to analyze in vitro entry and survival of two Streptococcus iniae serotypes. Efficient invasion by S. iniae occurred in both cells, but only the type II strain persisted in pronephros phagocytes for at least 48 h. Ex vivo ...

journal_title：Infection and immunity

authors： Zlotkin A,Chilmonczyk S,Eyngor M,Hurvitz A,Ghittino C,Eldar A

更新日期：2003-05-01 00:00:00

abstract：:An inactivated oral enterotoxigenic Escherichia coli (ETEC) vaccine against ETEC diarrhea was given to 25 adult Swedish volunteers. The vaccine consisted of formalin-killed E. coli bacteria expressing the most common colonization factor antigens (CFAs), i.e., CFA/I, -II, and -IV, and recombinantly produced cholera B s...

journal_title：Infection and immunity

authors： Ahrén C,Jertborn M,Svennerholm AM

更新日期：1998-07-01 00:00:00

abstract：:The T-cell-stimulating activity of staphylococcal enterotoxin B (SEB) is an important factor in the pathogenesis of certain staphylococcal diseases. To investigate the immunologically active domains of the SEB molecule, we have produced truncated fragments of recombinant SEB by C-terminal and N-terminal deletions. The...

journal_title：Infection and immunity

authors： Metzroth B,Marx T,Linnig M,Fleischer B

更新日期：1993-06-01 00:00:00

abstract：:Streptococcus pneumoniae is a major cause of illness and death in children in developing countries. In these children, zinc deficiency is associated with an increased risk of acute respiratory tract infections, which can be reduced by daily zinc administration. Severe infections decrease zinc levels in plasma and may ...

journal_title：Infection and immunity

authors： Strand TA,Hollingshead SK,Julshamn K,Briles DE,Blomberg B,Sommerfelt H

更新日期：2003-04-01 00:00:00

abstract：:C4BP (C4b-binding protein) is a high-molecular-weight plasma protein that inhibits the classical pathway of complement activation. Recent experiments have demonstrated that C4BP binds to many strains of the gram-positive bacterium Streptococcus pyogenes, a major respiratory tract pathogen. Binding to S. pyogenes was s...

journal_title：Infection and immunity

authors： Berggård K,Johnsson E,Mooi FR,Lindahl G

更新日期：1997-09-01 00:00:00

abstract：:The theoretic basis for developing conjugate vaccines, to induce immunoglobulin G (IgG) lipopolysaccharide (LPS) antibodies for the prevention of shigellosis, has been described (J. B. Robbins, C.-Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). The O-specific polysaccharides (O-SPs) of Shigella dysent...

journal_title：Infection and immunity

authors： Taylor DN,Trofa AC,Sadoff J,Chu C,Bryla D,Shiloach J,Cohen D,Ashkenazi S,Lerman Y,Egan W

更新日期：1993-09-01 00:00:00

abstract：:Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. We describe here how Streptococcus pneumoniae adopts a st...

journal_title：Infection and immunity

authors： Haleem KS,Ali YM,Yesilkaya H,Kohler T,Hammerschmidt S,Andrew PW,Schwaeble WJ,Lynch NJ

更新日期：2018-12-19 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00

abstract：:Twenty monoclonal antibodies have been prepared to the erythrocytes from CBA/Ca mice infected with the rodent malaria Plasmodium chabaudi. By immunofluorescence, 15 of these antibodies recognized parasite antigens expressed only during the development of mature trophozoites to schizonts and merozoites, 2 recognized pa...

journal_title：Infection and immunity

authors： Boyle DB,Newbold CI,Smith CC,Brown KN

更新日期：1982-10-01 00:00:00

abstract：:The Duffy binding protein (DBP) is a vital ligand for Plasmodium vivax blood-stage merozoite invasion, making the molecule an attractive vaccine candidate against vivax malaria. Similar to other blood-stage vaccine candidates, DBP allelic variation eliciting a strain-specific immunity may be a major challenge for deve...

journal_title：Infection and immunity

authors： Ntumngia FB,Schloegel J,Barnes SJ,McHenry AM,Singh S,King CL,Adams JH

更新日期：2012-03-01 00:00:00

abstract：:Bordetella parapertussis, a respiratory tract pathogen commonly regarded as noninvasive, was found to invade HeLa 229 cell monolayers. Following treatment of the monolayers with gentamicin, numbers of viable B. parapertussis recovered were comparable to those of invasive Salmonella and Shigella isolates. Invasion occu...

journal_title：Infection and immunity

authors： Ewanowich CA,Sherburne RK,Man SF,Peppler MS

更新日期：1989-04-01 00:00:00

abstract：:Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing ...

journal_title：Infection and immunity

authors： Malachowa N,Kohler PL,Schlievert PM,Chuang ON,Dunny GM,Kobayashi SD,Miedzobrodzki J,Bohach GA,Seo KS

更新日期：2011-01-01 00:00:00

abstract：:We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak paras...

journal_title：Infection and immunity

authors： Millar AE,Sternberg J,McSharry C,Wei XQ,Liew FY,Turner CM

更新日期：1999-07-01 00:00:00

abstract：:When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 10(8) cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phe...

journal_title：Infection and immunity

authors： Wickes BL,Golin JE,Kwon-Chung KJ

更新日期：1991-05-01 00:00:00

abstract：:HbhA of Mycobacterium tuberculosis is a multifunctional binding protein, binding to both sulfated sugars such as heparin and to human complement component C3. HbhA may therefore interact with host molecules and/or host cells during M. tuberculosis infection and play a role in the pathogenesis of this bacterium. The pu...

journal_title：Infection and immunity

authors： Mueller-Ortiz SL,Sepulveda E,Olsen MR,Jagannath C,Wanger AR,Norris SJ

更新日期：2002-12-01 00:00:00

abstract：:The coaggregation-defective (COG-) mutant Actinomyces viscosus T14V(PK455), which is unable to participate in lactose-sensitive adherence, and its COG+ parent were compared to structurally define the mutational loss of cell-associated lectin activity. Immunoelectrophoretic comparisons of crude extracts or isolated fim...

journal_title：Infection and immunity

authors： Cisar JO,Curl SH,Kolenbrander PE,Vatter AE

更新日期：1983-05-01 00:00:00

abstract：:Chlamydia trachomatis L2 is an obligate intracellular microorganism with a unique biphasic life cycle. The extracellular form, the elementary body (EB), is infectious but metabolically inactive. Attachment of EBs to host cells is medicated by a heparan sulfate-like glycosaminoglycan. Following attachment, the EB is in...

journal_title：Infection and immunity

authors： Birkelund S,Johnsen H,Christiansen G

更新日期：1994-11-01 00:00:00

abstract：:Macrophages are critical mediators of innate immunity and must be overcome for bacterial pathogens to cause disease. The Gram-positive bacterium Staphylococcus aureus produces virulence factors that impede macrophages and other immune cells. We previously determined that production of the metabolic cofactor lipoic aci...

journal_title：Infection and immunity

authors： Grayczyk JP,Alonzo F 3rd

更新日期：2019-09-19 00:00:00

abstract：:Pseudomonas aeruginosa bacteremia in cancer patients develops from initial gastrointestinal (GI) colonization with translocation into the bloodstream in the setting of chemotherapy-induced neutropenia and GI mucosal damage. We established a reproducible mouse model of P. aeruginosa GI colonization and systemic spread ...

journal_title：Infection and immunity

authors： Koh AY,Priebe GP,Pier GB

更新日期：2005-04-01 00:00:00

abstract：:Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integrity, and impaired N...

journal_title：Infection and immunity

authors： Elphinstone RE,Besla R,Shikatani EA,Lu Z,Hausladen A,Davies M,Robbins CS,Husain M,Stamler JS,Kain KC

更新日期：2017-08-18 00:00:00

abstract：:One rabbit pathogenic Escherichia coli strain, belonging to serogroup O103, harbors a self-transferable 117-kb plasmid (pREC-1) encoding resistance to several antibiotics. The role of this R plasmid in the colonization of the digestive tract in specific-pathogen-free (E. coli O103-free) rabbits was studied. Five-week-...

journal_title：Infection and immunity

authors： Reynaud A,Federighi M,Licois D,Guillot JF,Joly B

更新日期：1991-06-01 00:00:00

abstract：:Brucella abortus injected into CBA mice replicated primarily in the spleen and liver, reaching a peak bacterial count in both organs about 7 days postinfection. The organism was eliminated from the liver but declined to a chronic phase in the spleen. The infection caused hepatosplenomegaly. An influx of macrophages in...

journal_title：Infection and immunity

authors： Doyle AG,Halliday WJ,Barnett CJ,Dunn TL,Hume DA

更新日期：1992-04-01 00:00:00

abstract：:Although certain helminth infections preferentially induce type 2 T-cell responses, the immunological mechanisms responsible for type 2 T-cell polarization remain unclear. In the present study, we investigated the effects of excretory-secretory (ES) antigen from the nematode Nippostrongylus brasiliensis on cytokine pr...

journal_title：Infection and immunity

authors： Uchikawa R,Matsuda S,Arizono N

更新日期：2000-11-01 00:00:00

abstract：:A complex of trehalose-6, 6'-dimycolate (cord factor) and methylated bovine serum albumin was prepared, and its effect on the toxicity of cord factor in mice was studied. Either the active immunization with cord factor-methylated bovine serum albumin complex or the passive transfer of sera of rabbits vaccinated with t...

journal_title：Infection and immunity

authors： Kato M

更新日期：1972-02-01 00:00:00

abstract：:Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...

journal_title：Infection and immunity

authors： Kim SH,Jia W,Bishop RE,Gyles C

更新日期：2004-02-01 00:00:00