Abstract:
:Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing (SOK) in this study. Sequence analysis showed that the SOK gene is conserved in all sequenced S. aureus strains and homologous to the myosin cross-reactive antigen of Streptococcus pyogenes. Immunoblotting and immunofluorescence analysis showed that SOK was copurified with membrane fractions and was exposed on the surface of S. aureus Newman and RN4220. Comparative analysis of wild-type S. aureus and an isogenic deletion strain indicated that SOK contributes to both resistance to killing by human neutrophils and to oxidative stress. In addition, the S. aureus sok deletion strain showed dramatically reduced aortic valve vegetation and bacterial cell number in a rabbit endocarditis model. These results, plus the suspected role of the streptococcal homologue in certain diseases such as acute rheumatic fever, suggest that SOK plays an important role in cardiovascular and other staphylococcal infections.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Malachowa N,Kohler PL,Schlievert PM,Chuang ON,Dunny GM,Kobayashi SD,Miedzobrodzki J,Bohach GA,Seo KSdoi
10.1128/IAI.00736-10subject
Has Abstractpub_date
2011-01-01 00:00:00pages
342-52issue
1eissn
0019-9567issn
1098-5522pii
IAI.00736-10journal_volume
79pub_type
杂志文章abstract::Attachment of Mycobacterium avium subsp. paratuberculosis to host tissue and penetration of mucosal surfaces are pivotal events in the pathogenesis of Johne's disease. Fibronectin (FN) binding is required for attachment and internalization of several mycobacteria by epithelial cells in vitro. The objective of this stu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2075-2082.2001
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.3.1003-1009.1978
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journal_title:Infection and immunity
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doi:10.1128/IAI.2.2.201-208.1970
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5823-5831.2001
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.3.680-687.1977
更新日期:1977-12-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1971-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.6.1848-1852.1990
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.2.752-757.1982
更新日期:1982-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.1.108-114.1979
更新日期:1979-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.277-281.1985
更新日期:1985-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.9.3497-3503.1996
更新日期:1996-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5225-5232.1996
更新日期:1996-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.5107-5114.2002
更新日期:2002-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.3.776-781.1978
更新日期:1978-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.12.4693-4697.1991
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更新日期:2011-12-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2013-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.3.268-273.1970
更新日期:1970-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1985-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3768-3776.2002
更新日期:2002-07-01 00:00:00
abstract::The involvement of tumor necrosis factor (TNF) in resistance to Toxoplasma gondii infection was examined by means of experiments in which mice were treated with anti-TNF antibodies prior to infection with ME49, a low-virulence Toxoplasma strain. In (BALB/cBy x C57BL/6J)F1 (CB6F1) mice, which are highly resistant to in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.1979-1983.1992
更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00