Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I.

abstract：:We compared a cryptococcal culture filtrate antigen referred to as CneF with chemically defined cryptococcal antigen fractions isolated by Cherniak and co-workers by using double immunodiffusion gels, polyacrylamide gel electrophoresis, immunoblots, and footpad reactivity of immunized mice. The three previously descri...

journal_title：Infection and immunity

authors： Murphy JW,Mosley RL,Cherniak R,Reyes GH,Kozel TR,Reiss E

更新日期：1988-02-01 00:00:00

abstract：:Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe...

journal_title：Infection and immunity

authors： Mocny JC,Olson JS,Connell TD

更新日期：2007-10-01 00:00:00

abstract：:A 46-kDa hemolytic protein, referred to as cystalysin, from Treponema denticola ATCC 35404 was overexpressed in Escherichia coli LC-67. Both the native and recombinant 46-kDa proteins were purified to homogeneity. Both proteins expressed identical biological and functional characteristics. In addition to its biologica...

journal_title：Infection and immunity

authors： Chu L,Ebersole JL,Kurzban GP,Holt SC

更新日期：1997-08-01 00:00:00

abstract：:Strain superinfection occurs when a second pathogen strain infects a host already carrying a primary strain. Anaplasma marginale superinfection occurs when the second strain carries a variant repertoire different from that of the primary strain, and the epidemiologic consequences depend on the relative efficiencies of...

journal_title：Infection and immunity

authors： Galletti MF,Ueti MW,Knowles DP Jr,Brayton KA,Palmer GH

更新日期：2009-04-01 00:00:00

abstract：:Although Streptococcus intermedius and Streptococcus mutans are regarded as members of the commensal microflora of the body, S. intermedius is often associated with deep-seated purulent infections, whereas S. mutans is frequently associated with dental caries. In this study, we investigated the roles of the S. mutans ...

journal_title：Infection and immunity

authors： Petersen FC,Assev S,van der Mei HC,Busscher HJ,Scheie AA

更新日期：2002-01-01 00:00:00

abstract：:The objective of this study was to determine (i) if complementation of ureB-negative Helicobacter pylori restores colonization and (ii) if urease is a useful reporter for promoter activity in vivo. Strains used were M6, M6DeltaureB, and 10 recombinant derivatives of M6 or M6DeltaureB in which urease expression was und...

journal_title：Infection and immunity

authors： Eaton KA,Gilbert JV,Joyce EA,Wanken AE,Thevenot T,Baker P,Plaut A,Wright A

更新日期：2002-02-01 00:00:00

abstract：:Production of interleukin-10 (IL-10) by C57BL/6 mice following infection with Borrelia burgdorferi has been proposed as a mechanism whereby resistance to the development of experimental Lyme arthritis is maintained. In the current study, we sought to determine the role of IL-10 during infection of arthritis- and cardi...

journal_title：Infection and immunity

authors： Brown CR,Lai AY,Callen ST,Blaho VA,Hughes JM,Mitchell WJ

更新日期：2008-12-01 00:00:00

abstract：:We have previously shown that chinchillas infected with a multiply passaged laboratory strain of influenza A/NWS/33 (H1N1) develop negative middle-ear pressure; polymorphonuclear leukocyte oxidative, bactericidal, and chemotactic dysfunction; and increased susceptibility to pneumococcal otitis media. Because influenza...

journal_title：Infection and immunity

authors： Giebink GS,Wright PF

更新日期：1983-09-01 00:00:00

abstract：:Anthrax lethal toxin (LeTx), consisting of protective antigen (PA) and lethal factor (LF), rapidly kills primary mouse macrophages and macrophage-like cell lines such as RAW 264.7. LF is translocated by PA into the cytosol of target cells, where it acts as a metalloprotease to cleave mitogen-activated protein kinase k...

journal_title：Infection and immunity

authors： Tang G,Leppla SH

更新日期：1999-06-01 00:00:00

abstract：:Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by catabolizing it to kynurenine with consequences for C. trachom...

journal_title：Infection and immunity

authors： Ibana JA,Belland RJ,Zea AH,Schust DJ,Nagamatsu T,AbdelRahman YM,Tate DJ,Beatty WL,Aiyar AA,Quayle AJ

更新日期：2011-11-01 00:00:00

abstract：:The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...

journal_title：Infection and immunity

authors： Van Alst NE,Wellington M,Clark VL,Haidaris CG,Iglewski BH

更新日期：2009-10-01 00:00:00

abstract：:Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans. Although the infection in humans can be cleared by antibiotic therapy, persistence in reservoir animals is necessary for the maintenance of the bacterium in the natural reservoir host⇔tick vector inf...

journal_title：Infection and immunity

authors： LaFrance ME,Pierce JV,Antonara S,Coburn J

更新日期：2011-08-01 00:00:00

abstract：:Helicobacter infections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation in Helicobacter-induced gastritis is po...

journal_title：Infection and immunity

authors： Drakes ML,Czinn SJ,Blanchard TG

更新日期：2006-08-01 00:00:00

abstract：:Endotoxin may cause abnormal deposition of platelet-endotoxin aggregates, and this event could have damaging effects. We compared the aggregation characteristics of platelets from rabbits made tolerant to the lethal effects of endotoxin with those of platelets from normal rabbits. Platelets from tolerant rabbits aggre...

journal_title：Infection and immunity

authors： Walker RI,Shields LJ,Fletcher JR

更新日期：1978-03-01 00:00:00

abstract：:Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. In addition, B. burgdorferi encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in B. burgdorferi biology remain...

journal_title：Infection and immunity

authors： Thompson C,Mason C,Parrilla S,Ouyang Z

更新日期：2020-05-20 00:00:00

abstract：:Borrelia burgdorferi spirochetes that do not cause arthritis or carditis were developed and used to investigate Lyme disease pathogenesis. A clonal isolate of B. burgdorferi N40 (cN40), which induces disease in C3H/HeN (C3H) mice, was repeatedly passaged in vitro to generate nonpathogenic spirochetes. The passage 75 i...

journal_title：Infection and immunity

authors： Anguita J,Samanta S,Revilla B,Suk K,Das S,Barthold SW,Fikrig E

更新日期：2000-03-01 00:00:00

abstract：:Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...

journal_title：Infection and immunity

authors： Chai LY,Kullberg BJ,Vonk AG,Warris A,Cambi A,Latgé JP,Joosten LA,van der Meer JW,Netea MG

更新日期：2009-05-01 00:00:00

abstract：:It was previously determined that the type II secretion system (T2SS) promotes the ability of Legionella pneumophila to grow in coculture with amoebae. Here, we discerned the stage of intracellular infection that is potentiated by comparing the wild-type and T2SS mutant legionellae for their capacity to parasitize Aca...

journal_title：Infection and immunity

authors： White RC,Truchan HK,Zheng H,Tyson JY,Cianciotto NP

更新日期：2019-10-18 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...

journal_title：Infection and immunity

authors： Zuverink M,Chen C,Przedpelski A,Blum FC,Barbieri JT

更新日期：2015-07-01 00:00:00

abstract：:Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal t...

journal_title：Infection and immunity

authors： Le Cabec V,Cols C,Maridonneau-Parini I

更新日期：2000-08-01 00:00:00

abstract：:Escherichia coli is a major cause of enteric/diarrheal diseases, urinary tract infections, and sepsis. E. coli K1 is the leading gram-negative organism causing neonatal meningitis, but the microbial basis of E. coli K1 meningitis is incompletely understood. Here we employed comparative genomic hybridization to investi...

journal_title：Infection and immunity

authors： Yao Y,Xie Y,Kim KS

更新日期：2006-04-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis i...

journal_title：Infection and immunity

authors： Greenberg DE,Sturdevant DE,Marshall-Batty KR,Chu J,Pettinato AM,Virtaneva K,Lane J,Geller BL,Porcella SF,Gallin JI,Holland SM,Zarember KA

更新日期：2015-11-01 00:00:00

abstract：:Mycoplasma arthritidis induces an acute to chronic arthritis in rodents. Arthritis induced in mice histologically resembles human rheumatoid arthritis and can be associated with lethal toxicity following systemic injection. The M. arthritidis mitogen (MAM) superantigen has long been implicated as having a role in path...

journal_title：Infection and immunity

authors： Luo W,Yu H,Cao Z,Schoeb TR,Marron M,Dybvig K

更新日期：2008-11-01 00:00:00

abstract：:Purified and concentrated Venezuelan equine encephalitis (VEE) virus derived from tissue cultures, rendered noninfectious by ionizing radiation with retention of in vitro serological activity, also retained a high level of immunogenicity. In mice, fluid vaccines afforded excellent protection against lethal challenge w...

journal_title：Infection and immunity

authors： Gruber J

更新日期：1971-04-01 00:00:00

abstract：:The effects of cyclophosphamide (CY) treatment on acute murine cytomegalovirus (MCMV) infection were studied to explore the potential usefulness of MCMV as a means of detecting immune dysfunction and to identify host defense mechanisms important for protection against MCMV. Conditions found optimal for enhancing MCMV ...

journal_title：Infection and immunity

authors： Selgrade MK,Daniels MJ,Hu PC,Miller FJ,Graham JA

更新日期：1982-12-01 00:00:00

abstract：:The ability of Klebsiella pneumoniae strains to resist the bactericidal activity of serum was quantitated. The K. pneumoniae strains tested included mutants lacking the capsular polysaccharide and mutants having a modified lipopolysaccharide structure. The last mutants were obtained as phage-resistant mutants, and the...

journal_title：Infection and immunity

authors： Tomás JM,Benedí VJ,Ciurana B,Jofre J

更新日期：1986-10-01 00:00:00

abstract：:The virulence and fitness in vivo of the major human pathogen Staphylococcus aureus are associated with a cell-to-cell signaling mechanism known as quorum sensing (QS). QS coordinates the production of virulence factors via the production and sensing of autoinducing peptide (AIP) signal molecules by the agr locus. Her...

journal_title：Infection and immunity

authors： Pollitt EJ,West SA,Crusz SA,Burton-Chellew MN,Diggle SP

更新日期：2014-03-01 00:00:00

abstract：:The pathogenicities of three proteases from Serratia marcescens, two proteases from Pseudomonas aeruginosa, and one thermolysin from Bacillus stearothermophilus were examined. All proteases tested caused acute liquefactive necrosis of the cornea and descemetocele formation in guinea pig eyes after intrastromal injecti...

journal_title：Infection and immunity

authors： Molla A,Matsumura Y,Yamamoto T,Okamura R,Maeda H

更新日期：1987-10-01 00:00:00

abstract：:Listeria monocytogenes is an intracellular bacterial pathogen that invades epithelial cells by subverting two cellular receptors, E-cadherin and Met. We recently identified type II phosphatidylinositol 4-kinases alpha and beta (PI4KIIalpha and PI4KIIbeta) as being required for bacterial entry downstream of Met. In thi...

journal_title：Infection and immunity

authors： Tham TN,Gouin E,Rubinstein E,Boucheix C,Cossart P,Pizarro-Cerda J

更新日期：2010-01-01 00:00:00

abstract：:Studies with animal models have demonstrated that viral respiratory tract infections suppress bacterial clearance processes in the lung and that this alteration in host defenses appears to explain the excessive mortality from bacterial pneumonia during influenza epidemics. However, since the pathogenesis of postinflue...

journal_title：Infection and immunity

authors： Nugent KM,Pesanti EL

更新日期：1983-12-01 00:00:00