Regulation of murine dendritic cell immune responses by Helicobacter felis antigen.

abstract：:Periodontitis is a bacterium-induced chronic inflammation that destroys tissues that attach teeth to jaw bone. Pathologically excessive matrix metalloproteinase 8 (MMP-8) is among the key players in periodontal destruction by initiating type I collagen degradation. We studied MMP-8 in Porphyromonas gingivalis-induced ...

journal_title：Infection and immunity

authors： Kuula H,Salo T,Pirilä E,Tuomainen AM,Jauhiainen M,Uitto VJ,Tjäderhane L,Pussinen PJ,Sorsa T

更新日期：2009-02-01 00:00:00

abstract：:Mononuclear phagocytes provide the major habitat of intracellular bacteria, including Mycobacterium tuberculosis and Mycobacterium bovis. The capacity of B-cell stimulatory factor 2 (interleukin-6 [IL-6]) to activate tuberculostatic functions was investigated by using murine bone marrow-derived macrophages (BMM phi). ...

journal_title：Infection and immunity

authors： Flesch IE,Kaufmann SH

更新日期：1990-01-01 00:00:00

abstract：:Malaria toxin causes hypoglycemia and induction of tumor necrosis factor. Extracts of parasitized erythrocytes which were coeluted and copurified with one of the two subtypes of mammalian insulin-mimetic inositolphosphoglycans similarly induced fibroblast proliferation in the absence of serum. In addition, induction o...

journal_title：Infection and immunity

authors： Caro HN,Sheikh NA,Taverne J,Playfair JH,Rademacher TW

更新日期：1996-08-01 00:00:00

abstract：:The presence of lipopolysaccharide (LPS) in gram-negative bacterial repeats-in-toxin (RTX) toxin preparations, as well as the harsh conditions required to remove it, suggests that LPS may complex with RTX toxins. Concentrated culture supernatant (CCS) preparations of the RTX toxin Pasteurella haemolytica leukotoxin (L...

journal_title：Infection and immunity

authors： Li J,Clinkenbeard KD

更新日期：1999-06-01 00:00:00

abstract：:Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) and TLR2-deficient (TLR2(-/-)) mice were inoculated with Streptococcus pneumoniae (...

journal_title：Infection and immunity

authors： Han F,Yu H,Tian C,Li S,Jacobs MR,Benedict-Alderfer C,Zheng QY

更新日期：2009-07-01 00:00:00

abstract：:To define the role of nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide (LOS) in the induction of proinflammatory cytokine gene expression during otitis media, we compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cel...

journal_title：Infection and immunity

authors： Tong HH,Chen Y,James M,Van Deusen J,Welling DB,DeMaria TF

更新日期：2001-06-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...

journal_title：Infection and immunity

authors： Rivoire B,Ranchoff BJ,Chatterjee D,Gaylord H,Tsang AY,Kolk AH,Aspinall GO,Brennan PJ

更新日期：1989-10-01 00:00:00

abstract：:Groups of mice were immunized either subcutaneously or intranasally with purified Brucella melitensis lipopolysaccharide (LPS) or with LPS as a noncovalent complex with Neisseria meningitidis group B outer membrane protein (LPS-GBOMP). Control mice were inoculated with sterile saline. Two doses of vaccine were given 4...

journal_title：Infection and immunity

authors： Bhattacharjee AK,Izadjoo MJ,Zollinger WD,Nikolich MP,Hoover DL

更新日期：2006-10-01 00:00:00

abstract：:T cells bearing the gammadelta antigen receptor (gammadelta T cells) can constitute up to 50% of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gammadelta T cells are involved in immune responses against Theileria parva. gammadelta T cells isolated from peripheral blo...

journal_title：Infection and immunity

authors： Daubenberger CA,Taracha EL,Gaidulis L,Davis WC,McKeever DJ

更新日期：1999-05-01 00:00:00

abstract：:The generation of nitric oxide (NO) by activated macrophages is believed to control mycobacterial infection in the murine system. In this study we examined the effect of Mycobacterium bovis BCG infection on the L-arginine-dependent NO pathway in J774.1 murine macrophages. We have confirmed previous results by demonstr...

journal_title：Infection and immunity

authors： Peteroy-Kelly M,Venketaraman V,Connell ND

更新日期：2001-09-01 00:00:00

abstract：:Helicobacter pylori mutants devoid of urease activity fail to colonize the gastric mucosa of mice; however, the effect of decreased levels of urease on colonization has not been examined. The nixA gene, required for full urease activity, encodes a cytoplasmic membrane nickel transporter that imports nickel ions and le...

journal_title：Infection and immunity

authors： Nolan KJ,McGee DJ,Mitchell HM,Kolesnikow T,Harro JM,O'Rourke J,Wilson JE,Danon SJ,Moss ND,Mobley HL,Lee A

更新日期：2002-02-01 00:00:00

abstract：:We studied apoptosis in a human ileocecal adenocarcinoma tumor cell line (HCT-8) infected with Cryptosporidium parvum, from 2 to 72 h postinfection (h.p.i.). At 2 h.p.i., the percentage of annexin V-positive cells in the cell culture had increased to 10% compared to 2.5% in noninfected control culture; sorted infected...

journal_title：Infection and immunity

authors： Mele R,Gomez Morales MA,Tosini F,Pozio E

更新日期：2004-10-01 00:00:00

abstract：:CD8(+) T lymphocytes often play a primary role in adaptive immunity to cytosolic microbial pathogens. Surprisingly, CD8(+) T cells are not required for protective immunity to the enteric pathogen Shigella flexneri, despite the ability of Shigella to actively secrete proteins into the host cytoplasm, a location from wh...

journal_title：Infection and immunity

authors： Jehl SP,Doling AM,Giddings KS,Phalipon A,Sansonetti PJ,Goldberg MB,Starnbach MN

更新日期：2011-05-01 00:00:00

abstract：:Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibo...

journal_title：Infection and immunity

authors： Cerca N,Jefferson KK,Maira-Litrán T,Pier DB,Kelly-Quintos C,Goldmann DA,Azeredo J,Pier GB

更新日期：2007-07-01 00:00:00

abstract：:Rhodococcus equi is a facultative intracellular pathogen of macrophages, relying on the presence of a conjugative virulence plasmid harboring a 21-kb pathogenicity island (PAI) for growth in host macrophages. The PAI encodes a family of 6 virulence-associated proteins (Vaps) in addition to 20 other proteins. The contr...

journal_title：Infection and immunity

authors： Coulson GB,Miranda-CasoLuengo AA,Miranda-CasoLuengo R,Wang X,Oliver J,Willingham-Lane JM,Meijer WG,Hondalus MK

更新日期：2015-08-01 00:00:00

abstract：:Gnotobiotic calves were inoculated with an O5:K4:H-, urease-positive strain of Escherichia coli isolated from a 2-day-old calf with diarrhea. The calves developed elevated temperatures and passed loose mucoid feces, with or without blood. The E. coli strain was negative for heat-stable and heat-labile enterotoxins but...

journal_title：Infection and immunity

authors： Moxley RA,Francis DH

更新日期：1986-08-01 00:00:00

abstract：:A T antigen preparation free of trypsin was obtained by application of CNBr-Sepharose linked to pure trypsin. Purification on an ion exchange chromatography column results in an electrophoretically homogeneous preparation of T protein. ...

journal_title：Infection and immunity

authors： Ludwicka A

更新日期：1976-03-01 00:00:00

abstract：:A recombinant 23-kDa protein (rBPI23) derived from human bactericidal/permeability-increasing protein (BPI) possesses potent endotoxin-neutralizing abilities in vitro and in vivo. Binding of rBPI23 to those endotoxins (lipopolysaccharides [LPSs]) encountered clinically would be a prerequisite for efficacy in decreasin...

journal_title：Infection and immunity

authors： Appelmelk BJ,An YQ,Thijs BG,MacLaren DM,de Graaff J

更新日期：1994-08-01 00:00:00

abstract：:DNA microarrays provide an opportunity to combine the principles of signature-tagged mutagenesis (STM) with microarray technology to identify potentially important bacterial virulence genes. The scope of DNA microarrays allows for less laborious screening on a much larger scale than possible by STM alone. We have adap...

journal_title：Infection and immunity

authors： Chan K,Kim CC,Falkow S

更新日期：2005-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharide from Gram-negative bacteria, plays a major role in resistance of mice and humans to Salmonella infection. In chickens, Salmonella may establish a carrier state whereby bacteria are able to persist in the host organism without triggering clinical signs. B...

journal_title：Infection and immunity

authors： Chaussé AM,Grépinet O,Bottreau E,Le Vern Y,Menanteau P,Trotereau J,Robert V,Wu Z,Kerboeuf D,Beaumont C,Velge P

更新日期：2011-08-01 00:00:00

abstract：:The concept that relates low virulence of certain alphaviruses to low viremia and efficient vascular clearance of virus was tested in guinea pigs. Previously published studies with hamsters suggested that virulent strains maintain high viremias primarily because they are cleared inefficiently from the blood. In the pr...

journal_title：Infection and immunity

authors： Jahrling PB,Heisey GB,Hesse RA

更新日期：1977-08-01 00:00:00

abstract：:A crude complex containing group C polysaccharide, outer membrane proteins, and lipopolysaccharide (LPS) was isolated from the cell-free culture liquid of Neisseria meningitidis serogroup C, serotype 2a. Group C polysaccharide and LPS were removed from this complex, resulting in an outer membrane complex and a purifie...

journal_title：Infection and immunity

authors： Beuvery EC,Miedema F,van Delft RW,Haverkamp J,Leussink AB,te Pas BJ,Teppema KS,Tiesjema RH

更新日期：1983-04-01 00:00:00

abstract：:The majority of strains of Actinobacillus actinomycetemcomitans isolated from patients with periodontal diseases secrete a leukotoxin that destroys human myeloid cells within minutes but has no effect on viability of peripheral blood lymphocytes in culture for 1.5 h. However, since this organism persists in the gingiv...

journal_title：Infection and immunity

authors： Mangan DF,Taichman NS,Lally ET,Wahl SM

更新日期：1991-09-01 00:00:00

abstract：:l-Arginine (1 M) eluted measles virus adsorbed on monkey erythrocytes without affecting the infectious and hemagglutinating activities of the virus. This phenomenon was also observed for encephalomyocarditis virus and Newcastle disease virus. ...

journal_title：Infection and immunity

authors： Lebon P,Protat A,Moline P

更新日期：1975-06-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Pseudomonas aeruginosa invades various epithelial cell types in vitro and in vivo. The P. aeruginosa genome possesses a gene (flhA) which encodes a protein that is believed to be part of the export apparatus for flagellum assembly and which is homologous to invA of Salmonella spp. Because invA is required for invasion...

journal_title：Infection and immunity

authors： Fleiszig SM,Arora SK,Van R,Ramphal R

更新日期：2001-08-01 00:00:00

abstract：:Ureaplasma urealyticum has previously been isolated from the cultured cerebrospinal fluid of 13 of 418 newborn infants; additional bloodstream isolates were obtained from the same population. Ten of the 13 cerebrospinal fluid and 3 bloodstream isolates were available for serotyping in the present study. By the use of ...

journal_title：Infection and immunity

authors： Zheng X,Watson HL,Waites KB,Cassell GH

更新日期：1992-08-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:The extracellular adherence protein (Eap) is a multifunctional Staphylococcus aureus protein and broad-spectrum adhesin for several host matrix and plasma proteins. We investigated the interactions of full-length Eap and five recombinant tandem repeat domains with host proteins by use of surface plasmon resonance (BIA...

journal_title：Infection and immunity

authors： Hussain M,Haggar A,Peters G,Chhatwal GS,Herrmann M,Flock JI,Sinha B

更新日期：2008-12-01 00:00:00