Evaluation of the immunogenicity and vaccine potential of recombinant Plasmodium falciparum merozoite surface protein 8.

abstract：:Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

journal_title：Infection and immunity

authors： Addis MF,Rappelli P,Fiori PL

更新日期：2000-07-01 00:00:00

abstract：:Biomaterial-associated infections (BAI), which are predominantly caused by Staphylococcus epidermidis, are a significant problem in modern medicine. Biofilm formation is considered the pivotal element in the pathogenesis, but in previous mouse studies we retrieved S. epidermidis from peri-implant tissue. To assess the...

journal_title：Infection and immunity

authors： Broekhuizen CA,de Boer L,Schipper K,Jones CD,Quadir S,Feldman RG,Dankert J,Vandenbroucke-Grauls CM,Weening JJ,Zaat SA

更新日期：2007-03-01 00:00:00

abstract：:The purpose of our experiment was to evaluate the destructive potential of a strain of Actinomyces viscosus on the periodontium of sensitized rodents, describing the induced lesions on the basis of quantitative cytology. The experimental design comprised in principle the following procedures. Young germfree rats were ...

journal_title：Infection and immunity

authors： Guggenheim B,Schroeder HE

更新日期：1974-09-01 00:00:00

abstract：:Endotoxin-resistant C3H/HeJ mice were used to test the hypothesis that a macrophage product, possibly interleukin-1, might mediate the depression of liver cytochrome P-450-dependent drug metabolism in endotoxin-treated mice. Depression of liver drug metabolism by endotoxin was observed in normal mice (C3H/HeN) but not...

journal_title：Infection and immunity

authors： Ghezzi P,Saccardo B,Villa P,Rossi V,Bianchi M,Dinarello CA

更新日期：1986-12-01 00:00:00

abstract：:No studies to date clearly define the interactions between Porphyromonas gingivalis and human peripheral blood polymorphonuclear leukocytes (PMN), nor has a protective role for antibody to P. gingivalis been defined. Using a fluorochrome phagocytosis microassay, we investigated PMN phagocytosis and killing of P. gingi...

journal_title：Infection and immunity

authors： Cutler CW,Kalmar JR,Arnold RR

更新日期：1991-06-01 00:00:00

abstract：:The Syrian golden hamster (Mesocricetus auratus) is uniquely susceptible to a variety of intracellular pathogens and is an excellent model for a number of human infectious diseases. The molecular basis for this high level of susceptibility is unknown, and immunological studies related to this model have been limited b...

journal_title：Infection and immunity

authors： Melby PC,Tryon VV,Chandrasekar B,Freeman GL

更新日期：1998-05-01 00:00:00

abstract：:Optimal protective immunity against babesial infection is postulated to require both complement-fixing and opsonizing antibodies in addition to gamma interferon (IFN-gamma)-mediated macrophage activation. The rhoptry-associated protein 1 (RAP-1) of Babesia bigemina induces partial protective immunity and is a candidat...

journal_title：Infection and immunity

authors： Brown WC,McElwain TF,Palmer GH,Chantler SE,Estes DM

更新日期：1999-01-01 00:00:00

abstract：:Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does...

journal_title：Infection and immunity

authors： Nair SP,Bischoff M,Senn MM,Berger-Bächi B

更新日期：2003-07-01 00:00:00

abstract：:Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae...

journal_title：Infection and immunity

authors： Fan P,Dong F,Huang Y,Zhong G

更新日期：2002-01-01 00:00:00

abstract：:During the systemic phase of murine infection with Salmonella enterica serovar Typhimurium, bacterial virulence is correlated with the ability to grow and survive within host macrophages. Salmonella pathogenicity island 2 (SPI-2), encoding a type three secretion system, has emerged as an important contributor to Salmo...

journal_title：Infection and immunity

authors： Linehan SA,Rytkönen A,Yu XJ,Liu M,Holden DW

更新日期：2005-07-01 00:00:00

abstract：:A parasitic protozoan, Leishmania mexicana amazonensis, was previously made resistant to tunicamycin (J.A. Kink and K.-P. Chang, Proc. Natl. Acad. Sci. USA 84:1253-1257, 1987). In the present study, six different tunicamycin-resistant variants were biologically and biochemically compared with their parental wild type ...

journal_title：Infection and immunity

authors： Kink JA,Chang KP

更新日期：1987-07-01 00:00:00

abstract：:Plaque samples were obtained from tooth surfaces exhibiting typical lesions of root surface caries and were immediately cultured by a continuous anaerobic procedure. The bacterial composition of root caries flora was determined on individual samples. Representative isolates from each specimen were characterized by mor...

journal_title：Infection and immunity

authors： Syed SA,Loesche WJ,Pape HL Jr,grenier E

更新日期：1975-04-01 00:00:00

abstract：:By screening a genomic lambda library of Streptococcus equi subsp. zooepidemicus, we have cloned and sequenced a gene, termed fnz, encoding a fibronectin (Fn)-binding protein called FNZ. On the basis of the deduced amino acid sequence of FNZ, the mature protein has a molecular mass of approximately 61 kDa. Analysis of...

journal_title：Infection and immunity

authors： Lindmark H,Jacobsson K,Frykberg L,Guss B

更新日期：1996-10-01 00:00:00

abstract：:The possibility that preexisting specific serum antibody could suppress a defined mucosal immune response to a topically applied antigen was studied in rats. Hyperimmune serum antibody induced by parenteral immunization of rats with cholera toxoid markedly suppressed the mucosal immune response to enterically applied ...

journal_title：Infection and immunity

authors： Pierce NF

更新日期：1980-10-01 00:00:00

abstract：:The interaction between bacteria and fibronectin is believed to play an important role in the pathogenicity of clinically important Gram-positive cocci. In the present study, we identified a gene encoding a predicted fibronectin-binding protein of Enterococcus faecium (fnm), a homologue of Streptococcus pneumoniae pav...

journal_title：Infection and immunity

authors： Somarajan SR,La Rosa SL,Singh KV,Roh JH,Höök M,Murray BE

更新日期：2015-12-01 00:00:00

abstract：:Length and restriction site polymorphism within a 2.8-kb threonine-rich open reading frame from Cryptosporidium parvum was identified and used to determine the genotypes of isolates from calves and humans. In agreement with observations of other genetic loci, all calf isolates were identical at this locus. In contrast...

journal_title：Infection and immunity

authors： Carraway M,Tzipori S,Widmer G

更新日期：1997-09-01 00:00:00

abstract：:The mechanism of in vitro synergistic lysis of sheep erythrocytes by Corynebacterium ovis and Corynebacterium equi was investigated. Hemolysis required (i) the action of phospholipase D from C. ovis, (ii) the action of an extracellular protein of C. equi, and (iii) Mg2+. Maximum lysis required imposition on the system...

journal_title：Infection and immunity

authors： Bernheimer AW,Linder R,Avigad LS

更新日期：1980-07-01 00:00:00

abstract：:Cultured L929 cells infected with Rickettsia prowazekii had a greatly increased rate of hydrolysis of fatty acid from the oleic acid-radiolabeled phospholipids of the host cell membranes. The incorporation of fatty acid into phospholipid in an infected cell was only moderately inhibited relative to a mock-infected cel...

journal_title：Infection and immunity

authors： Winkler HH,Daugherty RM

更新日期：1989-01-01 00:00:00

abstract：:The recent development of acellular pertussis vaccines has been a significant improvement in the conventional whole-cell diphtheria-pertussis-tetanus toxoid vaccines, but high production costs will limit its widespread use in developing countries. Since Mycobacterium bovis BCG vaccination against tuberculosis is used ...

journal_title：Infection and immunity

authors： Nascimento IP,Dias WO,Mazzantini RP,Miyaji EN,Gamberini M,Quintilio W,Gebara VC,Cardoso DF,Ho PL,Raw I,Winter N,Gicquel B,Rappuoli R,Leite LC

更新日期：2000-09-01 00:00:00

abstract：:Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ...

journal_title：Infection and immunity

authors： Phan V,Belas R,Gilmore BF,Ceri H

更新日期：2008-11-01 00:00:00

abstract：:Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma m...

journal_title：Infection and immunity

authors： Nyindo M,Kariuki TM,Mola PW,Farah IO,Elson L,Blanton RE,King CL

更新日期：1999-02-01 00:00:00

abstract：:The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antig...

journal_title：Infection and immunity

authors： Mahajan B,Berzofsky JA,Boykins RA,Majam V,Zheng H,Chattopadhyay R,de la Vega P,Moch JK,Haynes JD,Belyakov IM,Nakhasi HL,Kumar S

更新日期：2010-11-01 00:00:00

abstract：:The objective of this study was to determine (i) if complementation of ureB-negative Helicobacter pylori restores colonization and (ii) if urease is a useful reporter for promoter activity in vivo. Strains used were M6, M6DeltaureB, and 10 recombinant derivatives of M6 or M6DeltaureB in which urease expression was und...

journal_title：Infection and immunity

authors： Eaton KA,Gilbert JV,Joyce EA,Wanken AE,Thevenot T,Baker P,Plaut A,Wright A

更新日期：2002-02-01 00:00:00

abstract：:Yersinia pseudotuberculosis inv mutant strains cured of the virulence plasmid exhibit thermoinducible adhesion to cultured mammalian cells. To identify the genes responsible for this phenotype, Y. pseudotuberculosis homologs of the Y. enterocolitica ail and the Y. pestis psa loci were identified. Mutations in the Y. p...

journal_title：Infection and immunity

authors： Yang Y,Merriam JJ,Mueller JP,Isberg RR

更新日期：1996-07-01 00:00:00

abstract：:Guinea pigs sensitized by repeated skin testing with potent, merthiolated coccidioidin, equal to Smith standard, exhibited erythema, edema, and an induration-like reaction to intradermal injection of the preparation. No statistically significant migration inhibition of peritoneal exudate macrophages from these animals...

journal_title：Infection and immunity

authors： Sinski JT,Reed GL,Kelley LM,LeFebvre R

更新日期：1973-02-01 00:00:00

abstract：:T lymphocyte subpopulations in the peripheral blood of children with congenital cytomegalovirus infections and in controls were enumerated with monoclonal antibodies. Infants of less than 1 year of age with symptomatic infections showed significant increases in the proportion of suppressor cells and decreases in the r...

journal_title：Infection and immunity

authors： Pass RF,Roper MA,August AM

更新日期：1983-09-01 00:00:00

abstract：:Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice signi...

journal_title：Infection and immunity

authors： Cano LE,Brummer E,Stevens DA,Restrepo A

更新日期：1992-05-01 00:00:00

abstract：:Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-gamma). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and ...

journal_title：Infection and immunity

authors： Mullarky IK,Szaba FM,Kummer LW,Wilhelm LB,Parent MA,Johnson LL,Smiley ST

更新日期：2007-05-01 00:00:00

abstract：:Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 10(3) suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to matin...

journal_title：Infection and immunity

authors： Spertzel RO,Crabbs CL,Vaughn RE

更新日期：1972-09-01 00:00:00

abstract：:The protective immunity conferred by T-cell subsets against infection with Treponema pallidum subsp. pertenue was studied. We demonstrated that hamster T cells can be separated into two subsets by monoclonal antibody (MAb) GK 1.5 (anti-L3T4) and MAb 38. Eighty-five percent of hamster thymocytes were L3T4+ and 87% were...

journal_title：Infection and immunity

authors： Liu H,Alder JD,Steiner BM,Stein-Streilein J,Lim L,Schell RF

更新日期：1991-02-01 00:00:00