A new restriction fragment length polymorphism from Cryptosporidium parvum identifies genetically heterogeneous parasite populations and genotypic changes following transmission from bovine to human hosts.

Abstract:

:Length and restriction site polymorphism within a 2.8-kb threonine-rich open reading frame from Cryptosporidium parvum was identified and used to determine the genotypes of isolates from calves and humans. In agreement with observations of other genetic loci, all calf isolates were identical at this locus. In contrast, human isolates showed two profiles, one found exclusively in humans and one a superposition of both profiles, which were indicative of heterogeneous parasite populations. PCR fingerprints were consistent with a change in the genetic profile of C. parvum isolates following transmission from bovine to human hosts.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Carraway M,Tzipori S,Widmer G

doi

10.1128/IAI.65.9.3958-3960.1997

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

3958-60

issue

9

eissn

0019-9567

issn

1098-5522

journal_volume

65

pub_type

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