Abstract:
:Length and restriction site polymorphism within a 2.8-kb threonine-rich open reading frame from Cryptosporidium parvum was identified and used to determine the genotypes of isolates from calves and humans. In agreement with observations of other genetic loci, all calf isolates were identical at this locus. In contrast, human isolates showed two profiles, one found exclusively in humans and one a superposition of both profiles, which were indicative of heterogeneous parasite populations. PCR fingerprints were consistent with a change in the genetic profile of C. parvum isolates following transmission from bovine to human hosts.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Carraway M,Tzipori S,Widmer Gdoi
10.1128/IAI.65.9.3958-3960.1997subject
Has Abstractpub_date
1997-09-01 00:00:00pages
3958-60issue
9eissn
0019-9567issn
1098-5522journal_volume
65pub_type
杂志文章abstract::The attachment of radioisotope-labeled Mycoplasma pneumoniae to hamster tracheal rings in organ culture was examined by radioautography and liquid scintillation counting. Radioautographs of individual rings exposed for 8 h to (3H) thymidine-labeled virulent M. pneumoniae revealed a dense extracellular collection of em...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.959-966.1976
更新日期:1976-03-01 00:00:00
abstract::We studied the influence of staphylococcal toxic shock syndrome toxin 1 and streptococcal erythrogenic (pyrogenic) toxin A (ETA) on intact and digitonin-permeabilized human polymorphonuclear granulocytes (PMNs). As was shown by reversed-phase high-performance liquid chromatography analysis, toxic shock syndrome toxin ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.3.1055-1061.1993
更新日期:1993-03-01 00:00:00
abstract::The flavivirus dengue and the arenavirus Junin are both associated with a hemorrhagic shock syndrome in man. We have demonstrated the replication of these viruses in vitro in both rabbit and human endothelial cells by viral titers and immunofluorescent antibody studies. Rabbit endothelium established in continuous cul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.3.776-781.1978
更新日期:1978-06-01 00:00:00
abstract::Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterized Leptospira interrogans catalase (KatE), the only annotated catalase found within pathogenic Leptospira species, by assessing its role in resist...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00466-12
更新日期:2012-11-01 00:00:00
abstract::C57BL/6 mice were infected intravenously with 6 X 10(3) Listeria monocytogenes organisms. As early as day 3 of infection, there was a marked reduction in the number of lymphocytes recovered from the peripheral blood, bone marrow, and thymuses of infected animals. Concomitantly, there was an increase in the number of s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.2.372-377.1984
更新日期:1984-08-01 00:00:00
abstract::In this communication, we examine the specificity of anti-herpes simplex virus (HSV) cytotoxic T lymphocytes (CTL). Serological studies of the two related HSV serotypes (HSV-1 and HSV-2) have revealed both type-specific and cross-reactive antigenic determinants in the viral envelope and on the surface of infected cell...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.3.795-803.1981
更新日期:1981-12-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.9.5908-5914.2005
更新日期:2005-09-01 00:00:00
abstract::Recently, a glycoprotein fraction, designated gp10/20, purified from Leishmania mexicana amazonensis was shown to induce a cellular immune response mediated by murine L3T4+ T lymphocytes. This fact led us to pursue further the characterization of this fraction. The present study demonstrated that gp10/20 is a degradat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.7.1766-1770.1988
更新日期:1988-07-01 00:00:00
abstract::Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.11.6318-6323.2004
更新日期:2004-11-01 00:00:00
abstract::Microsporidia are obligate intracellular parasites that are ubiquitous in nature and have been recognized as causing an important emerging disease among immunocompromised individuals. Limited knowledge exists about the immune response against these organisms, and virtually nothing is known about the receptors involved...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00733-08
更新日期:2008-10-01 00:00:00
abstract::Viral hepatitis caused by infection with murine hepatitis virus strain A59 has been shown to affect the mitotic response after partial hepatectomy in mice. Normal mice showed a delayed response, whereas nude mice did not show any response, even 5 days after partial hepatectomy. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.641-642.1981
更新日期:1981-08-01 00:00:00
abstract::Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.1387-1393.2006
更新日期:2006-02-01 00:00:00
abstract::An exoprotein of Staphylococcus aureus 100 that elicited a positive ileal loop response in the rabbit model was investigated in this study. The protein, as it occurred in the culture supernatant fluid, could be detected initially in the late log phase of growth under aerobic and anaerobic conditions. It was stable und...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.2.298-303.1977
更新日期:1977-11-01 00:00:00
abstract::We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg and 0.1 mg zymosan intra-articularly (i.a.). Test groups received an A. suum extract either per os (p.o.) or intraperitoneally (i.p....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01085-07
更新日期:2008-06-01 00:00:00
abstract::The involvement of tumor necrosis factor (TNF) in resistance to Toxoplasma gondii infection was examined by means of experiments in which mice were treated with anti-TNF antibodies prior to infection with ME49, a low-virulence Toxoplasma strain. In (BALB/cBy x C57BL/6J)F1 (CB6F1) mice, which are highly resistant to in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.1979-1983.1992
更新日期:1992-05-01 00:00:00
abstract::The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccinatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.3.897-898.1986
更新日期:1986-12-01 00:00:00
abstract::There is an emerging paradigm shift from coronary heart disease having a purely hereditary and nutritional causation to possibly having an infectious etiology. Recent epidemiological studies have shown a correlation between periodontal disease and coronary heart disease. However, to date, there is minimal information ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.5792-5798.1999
更新日期:1999-11-01 00:00:00
abstract::A nonproteolytic strain of Clostridium botulinum type B produces two toxins of different molecular weight (16S and 12S) that are indistinguishable from the corresponding toxins of a proteolytic strain in molecular weight and construction but differ in potential toxicity, activation ratio, and hemagglutinability. Succe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.987-989.1976
更新日期:1976-03-01 00:00:00
abstract::Helicobacter infections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation in Helicobacter-induced gastritis is po...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00289-06
更新日期:2006-08-01 00:00:00
abstract::Oxygenated fatty acids, or oxylipins, play an essential role in physiological signaling and developmental processes in animals, plants, and fungi. Previous characterization of three Aspergillus fumigatus dioxygenases (PpoA, PpoB, and PpoC), similar in sequence to mammalian cyclooxygenases, showed that PpoA is responsi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00009-08
更新日期:2008-07-01 00:00:00
abstract::Evidence is presented that the chronicity of infection in CBA mice after injection of Brucella abortus 19 is related to a number of factors: (i) the relative resistance of B. abortus to macrophage killing, which allowed some bacteria to survive the peak of macrophage activity occurring at 14 days; (ii) the decline in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.2.197-205.1979
更新日期:1979-02-01 00:00:00
abstract::Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00196-06
更新日期:2006-06-01 00:00:00
abstract::Mice pretreated intraperitoneally with trehalose-6,6'-dimycolate (cord factor) were protected against an intraperitoneal challenge with Salmonella typhi strain Ty2 or Salmonella typhimurium strain SR 11. The nonspecific resistance to S. typhi and S. typhimurium was still detectable 7 and 14 days, respectively, after a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.14.5.1125-1129.1976
更新日期:1976-11-01 00:00:00
abstract::Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and to evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract and a tick saliva protein, Salp15, inhibit in vitro keratinocy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00482-10
更新日期:2011-02-01 00:00:00
abstract::We measured the microbicidal peptides MCP-1 and MCP-2 in rabbit alveolar macrophages (AM), comparing rabbits pretreated with complete Freund adjuvant with untreated control animals. Levels of MCP-1 increased from 4.7 +/- 0.6 microgram/10(7) resident AM to 13.2 +/- 0.1 microgram/10(7) complete Freund adjuvant-elicited ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.3.775-778.1981
更新日期:1981-09-01 00:00:00
abstract::A variant enterotoxin gene, referred to as sezA+, has been identified. Staphylococcus aureus FRI1106, a staphylococcal enterotoxin type D producer (Sed+), contained HindIII fragments of 3.8 and 9.4 kilobase pairs (kbp) that hybridized in Southern blot analysis to a probe containing only staphylococcal enterotoxin type...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.6.1614-1619.1990
更新日期:1990-06-01 00:00:00
abstract::The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a signi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.12.7170-7172.2003
更新日期:2003-12-01 00:00:00
abstract::Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico str...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3576-3579.1994
更新日期:1994-08-01 00:00:00
abstract::Nine goats were injected transthoracically with Pasteurella haemolytica A1 to determine if an extracellular bacterial enzyme, neuraminidase, was produced in vivo during infection with this organism. The principal group of goats (n = 9) each received 1 ml of 7.25 x 10(5) live P. haemolytica A1 cells in polyacrylate bea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.10.4675-4678.1994
更新日期:1994-10-01 00:00:00
abstract::Assembly of adherent biofilms is the key mechanism involved in Staphylococcus epidermidis virulence during device-associated infections. Aside from polysaccharide intercellular adhesin (PIA), the accumulation-associated protein Aap and the extracellular matrix binding protein Embp act as intercellular adhesins, mediat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01142-10
更新日期:2011-06-01 00:00:00