Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice.

Abstract:

:Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some of which are able to modify the growth of M. tuberculosis in infected cells. Most experimental work has been carried out with Macrocyclon, also known as HOC 12.5EO. In this study, we demonstrate that Macrocyclon is effective in controlling M. tuberculosis infections, and we provide evidence that its effect is partially mediated by an l-arginine-dependent mechanism of macrophage activation that involves the activity of the inducible nitric oxide synthase. We also show that Macrocyclon is effective in athymic and major histocompatibility complex class II-/- mice and synthesized a number of structurally related calixarenes expressing significant antimycobacterial activity.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Colston MJ,Hailes HC,Stavropoulos E,Hervé AC,Hervé G,Goodworth KJ,Hill AM,Jenner P,Hart PD,Tascon RE

doi

10.1128/IAI.72.11.6318-6323.2004

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

6318-23

issue

11

eissn

0019-9567

issn

1098-5522

pii

72/11/6318

journal_volume

72

pub_type

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