Nonspecific resistance against infection with Salmonella typhi and Salmonella typhimurium induced in mice by cord factor (trehalose-6,6'-dimycolate) and its analogues.

abstract：:BALB/c mice were vaccinated by the intramuscular (i.m.) and subcutaneous (s.c.) routes with a native preparation of the Chlamydia trachomatis mouse pneumonitis (MoPn) major outer membrane protein (MOMP), using Montanide ISA 720 and CpG-1826 as adjuvants. A negative control group was immunized with ovalbumin and the tw...

journal_title：Infection and immunity

authors： Pal S,Peterson EM,de la Maza LM

更新日期：2005-12-01 00:00:00

abstract：:Macrophages encode several Toll-like receptors (TLRs) that recognize bacterial components, such as lipoproteins (TLR2) or lipopolysaccharides (TLR4), and activate multiple signaling pathways. Activation of transcription factor NF-kappaB by TLR2 or TLR4 signaling promotes proinflammatory and cell survival responses. Al...

journal_title：Infection and immunity

authors： Zhang Y,Bliska JB

更新日期：2003-03-01 00:00:00

abstract：:Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ...

journal_title：Infection and immunity

authors： Ho M,Nash C,Morgan CW,Armstrong JA,Carroll RG,Postic B

更新日期：1974-02-01 00:00:00

abstract：:Streptococcus mutans produces several enzymes which metabolize sucrose. Three glucosyltransferase genes (gtfB, gtfC, and gtfD) and a single fructosyltransferase gene (ftf) encode enzymes which are important in formation of exopolysaccharides. Mutants of S. mutans V403 carrying single and multiple mutations of the gtfB...

journal_title：Infection and immunity

authors： Munro C,Michalek SM,Macrina FL

更新日期：1991-07-01 00:00:00

abstract：:AMA-1 of Plasmodium falciparum is a promising candidate antigen in malaria vaccine development. In this study, we have mapped the immunodominant T-cell determinants in this antigen by using synthetic peptides. From the amphipathic scores, 17 putative T-cell determinants were identified. Nine of the 17 peptides complem...

journal_title：Infection and immunity

authors： Lal AA,Hughes MA,Oliveira DA,Nelson C,Bloland PB,Oloo AJ,Hawley WE,Hightower AW,Nahlen BL,Udhayakumar V

更新日期：1996-03-01 00:00:00

abstract：:Virulent and avirulent clones of Leishmania donovani promastigotes were examined for their acid phosphatase activity. The acid phosphatase activity of whole-cell lysates of virulent clones was 1.5 to 2.0 times higher than that of avirulent clones. Pellet fractions (260,000 x g, 30 min) from sonicated promastigotes of ...

journal_title：Infection and immunity

authors： Katakura K,Kobayashi A

更新日期：1988-11-01 00:00:00

abstract：:We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5'-nucleotidase, and ATP-modifying enzymatic activities. The secretion is triggered a...

journal_title：Infection and immunity

authors： Zaborina O,Misra N,Kostal J,Kamath S,Kapatral V,El-Idrissi ME,Prabhakar BS,Chakrabarty AM

更新日期：1999-10-01 00:00:00

abstract：:Quorum-sensing systems are critical regulators of the expression of virulence factors of various organisms, including Pseudomonas aeruginosa. Las and Rhl are two major quorum-sensing components, and they are regulated by their corresponding autoinducers, N-3-oxododecanoyl homoserine lactone (3-oxo-C(12)-HSL) and N-but...

journal_title：Infection and immunity

authors： Tateda K,Ishii Y,Horikawa M,Matsumoto T,Miyairi S,Pechere JC,Standiford TJ,Ishiguro M,Yamaguchi K

更新日期：2003-10-01 00:00:00

abstract：:We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak paras...

journal_title：Infection and immunity

authors： Millar AE,Sternberg J,McSharry C,Wei XQ,Liew FY,Turner CM

更新日期：1999-07-01 00:00:00

abstract：:Guinea pigs were treated with anti-CD18 antibody (M8), and subsequently middle ears (ME) were infected with nontypeable Haemophilus influenzae. Forty-eight hours after infection, the ME washes of these animals had significantly lower polymorphonuclear leukocyte numbers but higher bacterial counts compared with washes ...

journal_title：Infection and immunity

authors： Patel J,Chonmaitree T,Schmalstieg F

更新日期：1993-03-01 00:00:00

abstract：:The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to the OM's ability to function as a molecular permeability barrier tha...

journal_title：Infection and immunity

authors： Giordano NP,Cian MB,Dalebroux ZD

更新日期：2020-06-22 00:00:00

abstract：:To determine the ability of gut antigens to induce a protective immune response against blood-feeding nematodes, isolated gut antigens were used to immunize goats against Haemonchus contortus. Immunization-induced antibody responses recognized parasite gut antigens which were associated predominantly with the microvil...

journal_title：Infection and immunity

authors： Jasmer DP,McGuire TC

更新日期：1991-12-01 00:00:00

abstract：:Although excystation is crucial to the initiation of infection by Giardia lamblia, little is known about the regulation of this important process. We have been able to reliably induce excystation in vitro by mimicking cyst passage through the stomach and upper small intestine by the exposure of in vitro-derived cysts ...

journal_title：Infection and immunity

authors： Meng TC,Hetsko ML,Gillin FD

更新日期：1996-06-01 00:00:00

abstract：:The chemoattraction of Propionibacterium acnes lipase for neutrophils and the effect of lipase inhibitor and two antibiotic agents on the chemotaxis were evaluated. Of the various fractions tested, partially purified lipase (fraction 2c) was the most active cytotaxin produced by P. acnes. Serum mediators were not requ...

journal_title：Infection and immunity

authors： Lee WL,Shalita AR,Suntharalingam K,Fikrig SM

更新日期：1982-01-01 00:00:00

abstract：:Listeria monocytogenes is an intracellular bacterial pathogen which causes bacteremia and has a tropism for the central nervous system and a propensity to cause maternofetal infection. L. monocytogenes has been shown to be an effective prophylactic and a therapeutic vaccine vector for viral and tumor antigens in anima...

journal_title：Infection and immunity

authors： Angelakopoulos H,Loock K,Sisul DM,Jensen ER,Miller JF,Hohmann EL

更新日期：2002-07-01 00:00:00

abstract：:Filifactor alocis is a recently recognized periodontal pathogen; however, little is known regarding its interactions with the immune system. As the first-responder phagocytic cells, neutrophils are recruited in large numbers to the periodontal pocket, where they play a crucial role in the innate defense of the periodo...

journal_title：Infection and immunity

authors： Armstrong CL,Miralda I,Neff AC,Tian S,Vashishta A,Perez L,Le J,Lamont RJ,Uriarte SM

更新日期：2016-11-18 00:00:00

abstract：:We have previously shown that splenocytes from mice acutely infected with Trypanosoma cruzi exhibit high levels of nitric oxide (NO)-mediated apoptosis. In the present study, we used the gamma interferon (IFN-gamma)-knockout (IFN-gamma(-/-)) mice to investigate the role of IFN-gamma in modulating apoptosis induction a...

journal_title：Infection and immunity

authors： Martins GA,Vieira LQ,Cunha FQ,Silva JS

更新日期：1999-08-01 00:00:00

abstract：:The selC tRNA gene is a common site for the insertion of pathogenicity islands in a variety of bacterial enteric pathogens. We demonstrate here that Escherichia coli that produces Shiga toxin 2d and does not harbor the locus of enterocyte effacement (LEE) contains, instead, a novel genomic island. In one representativ...

journal_title：Infection and immunity

authors： Schmidt H,Zhang WL,Hemmrich U,Jelacic S,Brunder W,Tarr PI,Dobrindt U,Hacker J,Karch H

更新日期：2001-11-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:Sonicated preparations of capsulated Haemophilus influenzae type b, two of its spontaneous mutants, one containing patches of capsules (class I variant) and the other noncapsulated (class II variant), and a noncapsulated strain of H. influenzae type d were analyzed by crossed-immunoelectrophoresis using unadsorbed ant...

journal_title：Infection and immunity

authors： Buckmire FL

更新日期：1976-06-01 00:00:00

abstract：:We have previously identified mgrA (rat) as a regulator of autolysis in Staphylococcus aureus. Besides its effect on autolytic activity, we recently found alterations in the expression of regulator and target virulence genes in the mgrA mutant. Northern analysis and transcription fusion assays showed that inactivation...

journal_title：Infection and immunity

authors： Ingavale S,van Wamel W,Luong TT,Lee CY,Cheung AL

更新日期：2005-03-01 00:00:00

abstract：:Screening of a Mycobacterium tuberculosis genomic DNA library in the lambda gt11 expression vector was carried out by using, as probes, sera from tuberculous patients and murine monoclonal antibody H61.3 recognizing a mycobacterial 35-kilodalton protein present only on the M. tuberculosis complex. The recombinant beta...

journal_title：Infection and immunity

authors： Vismara D,Mezzopreti MF,Gilardini Montani MS,Del Porto P,Lombardi G,Piccolella E,Damiani G,Rappuoli R,Colizzi V

更新日期：1990-01-01 00:00:00

abstract：:Recent studies have shown that probiotics are beneficial in T-cell-mediated inflammatory diseases. The molecular mechanism by which probiotics work remains elusive, but accumulating evidence indicates that probiotics can modulate immune cell responses. Since T cells express receptors for bacterial products or componen...

journal_title：Infection and immunity

authors： Peluso I,Fina D,Caruso R,Stolfi C,Caprioli F,Fantini MC,Caspani G,Grossi E,Di Iorio L,Paone FM,Pallone F,Monteleone G

更新日期：2007-04-01 00:00:00

abstract：:Immunization of New Zealand White rabbits with purified visna virus elicited antibody activity demonstrated by passive hemagglutination (PHA), complement fixation (CF), and indirect immunofluorescent tests. The antibody activities of hyperimmune sera and Sephadex G-200 fractions of the sera were studied. It was found ...

journal_title：Infection and immunity

authors： Karl SC,Thormar H

更新日期：1971-12-01 00:00:00

abstract：:After lysing the phagocytic vacuole, Shigella spp. accumulate filaments of polymerized actin on their surface at one pole, leading to the formation of actin tails that enable them to move through the cytoplasm. We have recently demonstrated that the Shigella protein IcsA is located at the pole that is adjacent to the ...

journal_title：Infection and immunity

authors： Goldberg MB,Theriot JA,Sansonetti PJ

更新日期：1994-12-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a major metabolic end product detected in deep periodontal pockets that is produced by resident periodontopathic microbiota associated with the progression of periodontitis. Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabo...

journal_title：Infection and immunity

authors： Chu L,Dong Z,Xu X,Cochran DL,Ebersole JL

更新日期：2002-03-01 00:00:00

abstract：:Contributions of the alternative sigma factor sigmaB to Listeria monocytogenes infection were investigated using strains bearing null mutations in sigB, prfA, or inlA or in selected inlA or prfA promoter regions. The DeltaP4inlA strain, which has a deletion in the sigmaB-dependent P4inlA promoter, and the DeltasigB st...

journal_title：Infection and immunity

authors： Garner MR,Njaa BL,Wiedmann M,Boor KJ

更新日期：2006-02-01 00:00:00

abstract：:After intranasal inoculation, Brucella melitensis chronically infects the mononuclear phagocyte system in BALB/c mice, but it causes no apparent illness. Adaptive immunity, which can be transferred by either T cells or antibody from immune to naive animals, confers resistance to challenge infection. The role of innate...

journal_title：Infection and immunity

authors： Izadjoo MJ,Polotsky Y,Mense MG,Bhattacharjee AK,Paranavitana CM,Hadfield TL,Hoover DL

更新日期：2000-09-01 00:00:00

abstract：:Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxificatio...

journal_title：Infection and immunity

authors： Tunbridge AJ,Stevanin TM,Lee M,Marriott HM,Moir JW,Read RC,Dockrell DH

更新日期：2006-01-01 00:00:00

abstract：:Haemophilus ducreyi is resistant to killing by normal serum antibody and complement. We discovered an H. ducreyi outer membrane protein required for expression of serum resistance and termed it DsrA (for "ducreyi serum resistance A"). The dsrA locus was cloned, sequenced, and mutagenized. An isogenic mutant (FX517) of...

journal_title：Infection and immunity

authors： Elkins C,Morrow KJ Jr,Olsen B

更新日期：2000-03-01 00:00:00