Neutrophil chemotaxis by Propionibacterium acnes lipase and its inhibition.

abstract：:Vaccination with native full-length merozoite surface protein 1 (MSP1) or with recombinant C-terminal peptides protects mice against lethal challenge with virulent malaria parasites. To determine whether other regions of MSP1 can also induce protection, Plasmodium yoelii MSP1 was divided into four separate regions. Ea...

journal_title：Infection and immunity

authors： Tian JH,Kumar S,Kaslow DC,Miller LH

更新日期：1997-08-01 00:00:00

abstract：:A recent study found that group A Streptococcus (GAS) expresses a cell surface protein with similarity to human collagen (S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. R. Reid, G. G. Adams, and J. M. Musser, Infect. Immun. 68:6542-6553, 2000). This streptococcal collagen-like protein (Scl) cont...

journal_title：Infection and immunity

authors： Lukomski S,Nakashima K,Abdi I,Cipriano VJ,Shelvin BJ,Graviss EA,Musser JM

更新日期：2001-03-01 00:00:00

abstract：:Outer membrane porin genes of Salmonella typhimurium, including ompC, ompF, and tppB, are regulated by the products of ompB, a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date no one has studied the intracellular trafficking of S. typhimurium porin-...

journal_title：Infection and immunity

authors： Mills SD,Ruschkowski SR,Stein MA,Finlay BB

更新日期：1998-04-01 00:00:00

abstract：:A clone bank of Pasteurella haemolytica A1 was constructed by partial digestion of the genomic DNA with Sau3A and ligation of 5- to 10-kilobase-pair fragments into the BamHI site of the plasmid vector pBR322. After transformation into Escherichia coli K-12, a total of 4 X 10(3) recombinant clones was obtained. These w...

journal_title：Infection and immunity

authors： Lo RY,Shewen PE,Strathdee CA,Greer CN

更新日期：1985-12-01 00:00:00

abstract：:Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...

journal_title：Infection and immunity

authors： Riley SP,Patterson JL,Martinez JJ

更新日期：2012-08-01 00:00:00

abstract：:A purified A-antigen preparation of Blastomyces dermatitidis was determined to be composed of five major glycoprotein bands, visible with Coomassie blue and periodic acid-Schiff staining of polyacrylamide gels. At least 20 additional protein bands were detected by using a silver stain, which was 100 times more sensiti...

journal_title：Infection and immunity

authors： Young KD,Larsh HW

更新日期：1981-07-01 00:00:00

abstract：:Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...

journal_title：Infection and immunity

authors： Chai LY,Kullberg BJ,Vonk AG,Warris A,Cambi A,Latgé JP,Joosten LA,van der Meer JW,Netea MG

更新日期：2009-05-01 00:00:00

abstract：:Haemophilus ducreyi, the causative agent of chancroid, produces a lipooligosaccharide (LOS) which terminates in N-acetyllactosamine. This glycoform can be further extended by the addition of a single sialic acid residue to the terminal galactose moiety. H. ducreyi does not synthesize sialic acid, which must be acquire...

journal_title：Infection and immunity

authors： Post DM,Mungur R,Gibson BW,Munson RS Jr

更新日期：2005-10-01 00:00:00

abstract：:Previously, we isolated a high-molecular-weight immunogenic polysaccharide (designated PS) from Pseudomonas aeruginosa immunotype 1 (IT-1). The method which we used was modified to permit the isolation of a similar PS from P. aeruginosa IT-2. This antigen was composed primarily of carbohydrate, had a complex monosacch...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Sadoff JC

更新日期：1981-11-01 00:00:00

abstract：:In general there is a poor correlation between serum lipopolysaccharide (LPS; the biologically active constituent of endotoxin) levels and mortality in septic patients. The objective of this study was to determine if chemical, structural, or biological differences among LPS from different clinical isolates of gram-neg...

journal_title：Infection and immunity

authors： Luchi M,Morrison DC

更新日期：2000-04-01 00:00:00

abstract：:An immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation to...

journal_title：Infection and immunity

authors： Lawaly R,Konate L,Marrama L,Dia I,Diallo D,Diène Sarr F,Schneider BS,Casademont I,Diallo M,Brey PT,Sakuntabhai A,Mecheri S,Paul R

更新日期：2012-06-01 00:00:00

abstract：:A multigene family of 58- to 60-kDa proteins, which are designated rhoptry-associated protein 1 (RAP-1) and which come from the parasites Babesia bigemina and Babesia bovis, is a target for vaccine development. The presence of multiple gene copies and conserved sequences and epitopes of RAP-1 implies that these protei...

journal_title：Infection and immunity

authors： Rodríguez SD,Palmer GH,McElwain TF,McGuire TC,Ruef BJ,Chitko-McKown MG,Brown WC

更新日期：1996-06-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00

abstract：:In meningococcal septic shock, the dominant inducer of inflammation is lipopolysaccharide (LPS) in the outer membrane of Neisseria meningitidis, while interleukin-10 (IL-10) is the principal anti-inflammatory cytokine. We have used microarrays and Ingenuity Pathway Analysis to study the global effects of IL-10 on gene...

journal_title：Infection and immunity

authors： Gopinathan U,Ovstebø R,Olstad OK,Brusletto B,Dalsbotten Aass HC,Kierulf P,Brandtzaeg P,Berg JP

更新日期：2012-11-01 00:00:00

abstract：:We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak paras...

journal_title：Infection and immunity

authors： Millar AE,Sternberg J,McSharry C,Wei XQ,Liew FY,Turner CM

更新日期：1999-07-01 00:00:00

abstract：:Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice signi...

journal_title：Infection and immunity

authors： Cano LE,Brummer E,Stevens DA,Restrepo A

更新日期：1992-05-01 00:00:00

abstract：:Previous studies have demonstrated that animals exposed to Streptococcus pneumoniae while recovering from influenza A virus infection exhibit exacerbated disease symptoms. However, many of the current animal models exploring dual viral and bacterial synergistic exacerbations of respiratory disease have utilized mouse-...

journal_title：Infection and immunity

authors： Speshock JL,Doyon-Reale N,Rabah R,Neely MN,Roberts PC

更新日期：2007-06-01 00:00:00

abstract：:Brucella abortus and polyacrylic acid, two agents whose interferon-inducing capacity in the mouse has been well established, failed to stimulate circulating interferon production in rabbits, yet protected rabbits against local vaccinia virus infection. ...

journal_title：Infection and immunity

authors： De Clercq E,De Somer P

更新日期：1973-10-01 00:00:00

abstract：:The suppression of T-cell deoxyribonucleic acid (DNA) synthesis by serum from mice acutely with murine cytomegalovirus (MCMV) was investigated. Spleen cells from uninfected mice were exposed to concanavalin A in the presence of serum taken from mice at various times after infection with MCMV. The capacity of the serum...

journal_title：Infection and immunity

authors： Booss J,Wheelock EF

更新日期：1977-08-01 00:00:00

abstract：:Vaccination against Brucella infections in animals is usually performed by administration of live attenuated smooth B. abortus strain S19 and B. melitensis strain Rev1. They are proven effective vaccines against B. abortus in cattle and against B. melitensis and B. ovis in sheep and goats, respectively. However, both ...

journal_title：Infection and immunity

authors： Adone R,Ciuchini F,Marianelli C,Tarantino M,Pistoia C,Marcon G,Petrucci P,Francia M,Riccardi G,Pasquali P

更新日期：2005-07-01 00:00:00

abstract：:In this study we have characterized the association of a polysaccharide-deficient, lipid-rich lipopolysaccharide (LPS) with rabbit erythrocytes (RaRBC). With polymyxin B sulfate-mediated hemolysis as a probe, we have shown that Salmonella minnesota R595 LPS interacts with RaRBC in two distinguishable steps. The first ...

journal_title：Infection and immunity

authors： Carr C Jr,Morrison DC

更新日期：1984-02-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that causes human Chagas' disease, a leading source of congestive heart failure in Central and South America. CD8+ T cells are critical for control of T. cruzi infection, and CD8+ T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) acc...

journal_title：Infection and immunity

authors： Martin DL,Murali-Krishna K,Tarleton RL

更新日期：2010-07-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Genetic resistance to lethal infection with Rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Gilliam strain of R. tsutsugamushi showed three patterns of response: susceptible (A/HeJ, C3H/HeDub, C3H/HeJ, C3H/HeN, ...

journal_title：Infection and immunity

authors： Groves MG,Osterman JV

更新日期：1978-02-01 00:00:00

abstract：:A common concern with many autoimmune diseases of unknown etiology is the extent to which tissue T-lymphocyte infiltrates, versus a nonspecific infiltrate, reflect a response to the causative agent. Lyme arthritis can histologically resemble rheumatoid synovitis, particularly the prominent infiltration by T lymphocyte...

journal_title：Infection and immunity

authors： Roessner K,Trivedi H,Gaur L,Howard D,Aversa J,Cooper SM,Sigal LH,Budd RC

更新日期：1998-03-01 00:00:00

abstract：:The target organs of infection in guinea pigs with asymptomatic acquired or congenital syphilis were identified by PCR and in some cases by rabbit infectivity test (RIT). The prevalence of Treponema pallidum DNA was examined in the following seven organs: the inguinal and mesenteric lymph nodes, spleen, liver, kidney,...

journal_title：Infection and immunity

authors： Wicher K,Abbruscato F,Wicher V,Baughn R,Noordhoek GT

更新日期：1996-08-01 00:00:00

abstract：:Nineteen of 22 female mice (CF1 strain) inoculated intragastrically with Treponema hyodysenteriae developed cecal and colonic lesions consisting of catarrhal inflammation, edema, and occasional hemorrhage. ...

journal_title：Infection and immunity

authors： Joens LA,Glock RD

更新日期：1979-08-01 00:00:00

abstract：:We investigated the effect of the extracellular protease of Serratia marcescens on human serum constituents such as immunoglobulins, fibronectin, alpha 1-protease inhibitor, alpha 2-macroglobulin, lysozyme, and transferrin. At a very low concentration of Serratia 56-kilodalton protease (56K protease), purified human p...

journal_title：Infection and immunity

authors： Molla A,Matsumoto K,Oyamada I,Katsuki T,Maeda H

更新日期：1986-09-01 00:00:00

abstract：:Monoclonal antibodies secreted by six hybridomas and recognizing antigenic sites on glycoproteins gC, gAB, gD, gE, and gF of herpes simplex virus type 2 were examined for their ability to protect BALB/c mice from lethal infection by the virus. Administration of monoclonal antibodies to individual glycoproteins intrape...

journal_title：Infection and immunity

authors： Balachandran N,Bacchetti S,Rawls WE

更新日期：1982-09-01 00:00:00

abstract：:Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, eae-positive STEC strains, particularly those belonging to serogroups O157 and O111, appear to have greater virulence for humans. However, in spite of b...

journal_title：Infection and immunity

authors： Paton AW,Paton JC

更新日期：1999-11-01 00:00:00