Identification of a novel sialic acid transporter in Haemophilus ducreyi.

abstract：:The effects of passive administration of neutralizing monoclonal antibodies (MAB) to respiratory syncytial virus glycoproteins (GP90 and VP70) was evaluated in cotton rats challenged with respiratory syncytial virus. Animals injected with MAB to VP70 had lower mean viral titers in lung tissues than did controls (log10...

journal_title：Infection and immunity

authors： Walsh EE,Schlesinger JJ,Brandriss MW

更新日期：1984-02-01 00:00:00

abstract：:Differences in susceptibility to persistent cryptosporidial infection between two strains of adult athymic nude mice prompted us to investigate the immune mechanism(s) that may control resistance to infection in these T-cell-deficient mice. We studied fecal oocyst shedding, serum and fecal parasite-specific antibody r...

journal_title：Infection and immunity

authors： Adjei AA,Jones JT,Riggs MW,Enriquez FJ

更新日期：1999-08-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) isolated from human blood were exposed to various levels of hydrogen sulfide. The effect on respiratory burst, myeloperoxidase activity, and capacity to phagocytose and kill bacteria were studied. A 1-h exposure of the PMN to 1 mM sulfide did not decrease their myeloperoxidase activi...

journal_title：Infection and immunity

authors： Claesson R,Granlund-Edstedt M,Persson S,Carlsson J

更新日期：1989-09-01 00:00:00

abstract：:In bacterial infections, mononuclear and polymorphonuclear phagocytes are key components of host defenses. Recent investigations have indicated that chemokines are able to recruit and activate phagocytes. In particular, interleukin-8 (IL-8) attracts polymorphonuclear leukocytes (PMNs), while monocyte chemoattractant p...

journal_title：Infection and immunity

authors： Tonetti MS,Imboden MA,Gerber L,Lang NP,Laissue J,Mueller C

更新日期：1994-09-01 00:00:00

abstract：:We have previously shown that chinchillas infected with a multiply passaged laboratory strain of influenza A/NWS/33 (H1N1) develop negative middle-ear pressure; polymorphonuclear leukocyte oxidative, bactericidal, and chemotactic dysfunction; and increased susceptibility to pneumococcal otitis media. Because influenza...

journal_title：Infection and immunity

authors： Giebink GS,Wright PF

更新日期：1983-09-01 00:00:00

abstract：:Anthrax lethal toxin (LeTx), consisting of protective antigen (PA) and lethal factor (LF), rapidly kills primary mouse macrophages and macrophage-like cell lines such as RAW 264.7. LF is translocated by PA into the cytosol of target cells, where it acts as a metalloprotease to cleave mitogen-activated protein kinase k...

journal_title：Infection and immunity

authors： Tang G,Leppla SH

更新日期：1999-06-01 00:00:00

abstract：:White-footed mice (Peromyscus leucopus), the primary reservoir for Borrelia burgdorferi in the northern midwest and northeastern United States, were experimentally inoculated with an infectious strain or a noninfectious strain of the Lyme disease spirochete and examined for their specific antibody response with the en...

journal_title：Infection and immunity

authors： Schwan TG,Kime KK,Schrumpf ME,Coe JE,Simpson WJ

更新日期：1989-11-01 00:00:00

abstract：:A clone expressing a 35.5-kDa recombinant treponemal protein was isolated from a genomic DNA library constructed from Treponema pallidum street strain 14. Polyclonal antiserum raised against the recombinant protein reacted with a corresponding native protein of comparable size in T. pallidum that is specific to the pa...

journal_title：Infection and immunity

authors： Hubbard CL,Gherardini FC,Bassford PJ Jr,Stamm LV

更新日期：1991-04-01 00:00:00

abstract：:To characterize the roles of Porphyromonas gingivalis and its components in disease processes, we investigated the cytokine profiles induced by live P. gingivalis, its lipopolysaccharide (LPS), and its major fimbrial protein, fimbrillin (FimA). A cytokine antibody array revealed that human monocyte-derived macrophages...

journal_title：Infection and immunity

authors： Zhou Q,Amar S

更新日期：2006-02-01 00:00:00

abstract：:gammadelta T cells are considered crucial to the outcome of various infectious diseases. The present study was undertaken to characterize gammadelta (T-cell receptor 1(+) [TCR1(+)]) T cells phenotypically and functionally in avian immune response. Day-old chicks were orally immunized with Salmonella enterica serovar E...

journal_title：Infection and immunity

authors： Berndt A,Pieper J,Methner U

更新日期：2006-07-01 00:00:00

abstract：:We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...

journal_title：Infection and immunity

authors： Bisno AL,Craven DE,McCabe WR

更新日期：1987-03-01 00:00:00

abstract：:Culture filtrate proteins from Mycobacterium tuberculosis induce protective immunity in various animal models of tuberculosis. Two molecular mass regions (6 to 10 kDa and 24 to 36 kDa) of short-term culture filtrate are preferentially recognized by Th1 cells in animal models as well as by patients with minimal disease...

journal_title：Infection and immunity

authors： Rosenkrands I,Rasmussen PB,Carnio M,Jacobsen S,Theisen M,Andersen P

更新日期：1998-06-01 00:00:00

abstract：:Under certain circumstances, soluble antigens, particulate antigens, and/or microorganisms have been shown to bind to primate erythrocytes via complement receptor 1 (CR1) in the presence of specific antibodies and complement. This immune adherence reaction, specific for CR1, can lead to neutralization of antigens in t...

journal_title：Infection and immunity

authors： Powers JH,Buster BL,Reist CJ,Martin E,Bridges M,Sutherland WM,Taylor RP,Scheld WM

更新日期：1995-04-01 00:00:00

abstract：:The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to k...

journal_title：Infection and immunity

authors： Paton JC,Ferrante A

更新日期：1983-09-01 00:00:00

abstract：:A monoclonal antibody was used to characterize a 135-kDa surface-located membrane protein (Lmp1) generally present in Mycoplasma hominis strains. The monoclonal antibody, 552, was applied to identify the corresponding gene in an expression library of M. hominis PG21 DNA. The M. hominis PG21 lmp1 gene was sequenced, an...

journal_title：Infection and immunity

authors： Ladefoged SA,Birkelund S,Hauge S,Brock B,Jensen LT,Christiansen G

更新日期：1995-01-01 00:00:00

abstract：:Spiroplasmas were propagated in the Drosophila melanogaster cell line Dm-1. Spiroplasma citri and unidentified strains (corn shunt organism, 277F [tick isolate], powder puff, BNR-1, honey bee, and OBMG) grew to 10(8) to 10(9) colony-forming units per ml and could be passaged. Cytopathic effect (CPE) varied with the in...

journal_title：Infection and immunity

authors： Steiner T,McGarrity GJ,Phillips DM

更新日期：1982-01-01 00:00:00

abstract：:We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronec...

journal_title：Infection and immunity

authors： Avila JL,Rojas M,Rieber M

更新日期：1984-01-01 00:00:00

abstract：:Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates fr...

journal_title：Infection and immunity

authors： Moreau MF,Thibaud JL,Miled LB,Chaussepied M,Baumgartner M,Davis WC,Minoprio P,Langsley G

更新日期：1999-12-01 00:00:00

abstract：:DNA microarrays provide an opportunity to combine the principles of signature-tagged mutagenesis (STM) with microarray technology to identify potentially important bacterial virulence genes. The scope of DNA microarrays allows for less laborious screening on a much larger scale than possible by STM alone. We have adap...

journal_title：Infection and immunity

authors： Chan K,Kim CC,Falkow S

更新日期：2005-09-01 00:00:00

abstract：:The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in aroA, aroC, and htrA), were compared in a number of in vitro and in vivo assays. BRD1116 exhibited an increased susceptib...

journal_title：Infection and immunity

authors： Lowe DC,Savidge TC,Pickard D,Eckmann L,Kagnoff MF,Dougan G,Chatfield SN

更新日期：1999-02-01 00:00:00

abstract：:The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American...

journal_title：Infection and immunity

authors： Restrepo-Moreno A

更新日期：1970-09-01 00:00:00

abstract：:Antibody responses against proteins located on the surface or in the apical organelles of merozoites are presumed to be important components of naturally acquired protective immune responses against the malaria parasite Plasmodium falciparum. However, many merozoite antigens are highly polymorphic, and antibodies indu...

journal_title：Infection and immunity

authors： Cortés A,Mellombo M,Masciantonio R,Murphy VJ,Reeder JC,Anders RF

更新日期：2005-01-01 00:00:00

abstract：:Vero cytotoxin-producing Escherichia coli (VTEC) strains have been associated with sporadic cases and outbreaks of hemorrhagic colitis and with the hemolytic uremic syndrome in humans. Since adherence of enteric pathogens to epithelial surfaces is often a prerequisite for the subsequent delivery of bacterial enterotox...

journal_title：Infection and immunity

authors： Sherman P,Soni R,Karmali M

更新日期：1988-04-01 00:00:00

abstract：:Chlamydia trachomatis serovar E, the leading bacterial agent responsible for sexually transmitted diseases, is required to invade genital epithelial cells for its growth and survival, yet little is known about the adhesin-receptor interactions promoting its entry. In contrast, much has been published on the heparan su...

journal_title：Infection and immunity

authors： Davis CH,Raulston JE,Wyrick PB

更新日期：2002-07-01 00:00:00

abstract：:Sera from certain animal species contain a substance(s) which binds hepatitis B surface antigen. The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. This glycoprotein could be sel...

journal_title：Infection and immunity

authors： Millman I,McMichael JC

更新日期：1978-09-01 00:00:00

abstract：:H(2)O(2) levels accumulated by Mycoplasma pneumoniae can be influenced by carbon source, different horse sera, yeast extract, thallium acetate, or growth in a simplified, dialyzed medium. Thus, increased levels of H(2)O(2) were detected by growth in glycerol, by omission of thallium acetate, and by the use of dialyzed...

journal_title：Infection and immunity

authors： Low IE

更新日期：1971-01-01 00:00:00

abstract：:Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...

journal_title：Infection and immunity

authors： Jungnitz H,West NP,Walker MJ,Chhatwal GS,Guzmán CA

更新日期：1998-10-01 00:00:00

abstract：:Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of vir...

journal_title：Infection and immunity

authors： McClelland EE,Perrine WT,Potts WK,Casadevall A

更新日期：2005-10-01 00:00:00

abstract：:The Pseudomonas aeruginosa quorum-sensing systems, las and rhl, control the production of numerous virulence factors. In this study, we have used the burned-mouse model to examine the contribution of quorum-sensing systems to the pathogenesis of P. aeruginosa infections in burn wounds. Different quorum-sensing mutants...

journal_title：Infection and immunity

authors： Rumbaugh KP,Griswold JA,Iglewski BH,Hamood AN

更新日期：1999-11-01 00:00:00

abstract：:Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, eae-positive STEC strains, particularly those belonging to serogroups O157 and O111, appear to have greater virulence for humans. However, in spite of b...

journal_title：Infection and immunity

authors： Paton AW,Paton JC

更新日期：1999-11-01 00:00:00