Molecular cloning and characterization of a 35.5-kilodalton lipoprotein of Treponema pallidum.

abstract：:Previous studies in our laboratory have indicated that naturally resistant, inbred DBA/2J mice mount a greater serum antibody response to Pseudomonas aeruginosa 19660 than susceptible C57BL/6J mice. However, the specificity of the antibody produced was not known. The present study examines the specificity and kinetics...

journal_title：Infection and immunity

authors： Preston MJ,Berk JM,Hazlett LD,Berk RS

更新日期：1991-06-01 00:00:00

abstract：:Antiprotein monoclonal antibodies derived from mice inoculated with Rickettsia rickettsii heated at 56 degrees C for 15 min are of two types: one is type specific for epitopes denatured by moderate temperatures, and the other is specific for epitopes resistant to 100 degrees C for 5 min. The heat-resistant epitopes ar...

journal_title：Infection and immunity

authors： Anacker RL,McDonald GA,List RH,Mann RE

更新日期：1987-03-01 00:00:00

abstract：:The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a signi...

journal_title：Infection and immunity

authors： Ando M,Yoshimatsu T,Ko C,Converse PJ,Bishai WR

更新日期：2003-12-01 00:00:00

abstract：:Escherichia coli and other members of the family Enterobacteriaceae express surface fibrillar structures, fimbriae, that promote bacterial adhesion to host receptors. Type 1 fimbriae possess a lectinlike component, FimH, that is commonly thought to cause binding to mannose-containing oligosaccharides of host receptors...

journal_title：Infection and immunity

authors： Sokurenko EV,Courtney HS,Abraham SN,Klemm P,Hasty DL

更新日期：1992-11-01 00:00:00

abstract：:Nonspecific interactions related to physicochemical properties of bacterial cell surfaces, such as hydrophobicity and electrostatic charge, are known to have important roles in bacterium-host cell encounters. Streptococcus pneumoniae (pneumococcus) expresses multiple, surface-exposed, choline-binding proteins (CBPs) w...

journal_title：Infection and immunity

authors： Swiatlo E,Champlin FR,Holman SC,Wilson WW,Watt JM

更新日期：2002-01-01 00:00:00

abstract：:Several bacterial species recruit the complement regulators C4b-binding protein, factor H, and vitronectin, resulting in resistance against the bactericidal activity of human serum. It was recently demonstrated that bacteria also bind plasminogen, which is converted to plasmin that degrades C3b and C5. In this study, ...

journal_title：Infection and immunity

authors： Singh B,Al-Jubair T,Voraganti C,Andersson T,Mukherjee O,Su YC,Zipfel P,Riesbeck K

更新日期：2015-09-01 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:The interactions between Capnocytophaga ochracea ATCC 33596 and Streptococcus sanguis H1, Actinomyces naeslundii PK984, or Actinomyces israelii PK16 are dependent on specific recognitions between heat-sensitive adhesins on C. ochracea and heat-stable structures (probably carbohydrate-containing receptors) on the surfa...

journal_title：Infection and immunity

authors： Weiss EI,London J,Kolenbrander PE,Kagermeier AS,Andersen RN

更新日期：1987-05-01 00:00:00

abstract：:Utilization of the technique of immune electron microscopy has enabled the detection of a coronavirus in organ culture harvests derived from a washing from an adult with an acute upper respiratory tract illness; convalescent serum was the source of specific antibody. ...

journal_title：Infection and immunity

authors： Kapikian AZ,James HD,Kelly SJ,Vaughn AL

更新日期：1973-01-01 00:00:00

abstract：:The cyst cell wall β-glucans of Pneumocystis have been shown to stimulate immune responses in lung epithelial cells, dendritic cells, and alveolar macrophages. Little is known about how the trophic life forms, which do not have a fungal cell wall, interact with these innate immune cells. Here, we report differences in...

journal_title：Infection and immunity

authors： Evans HM,Bryant GL 3rd,Garvy BA

更新日期：2016-11-01 00:00:00

abstract：:Virus population dynamics in the lungs, trachea, and nasopharynx of Swiss-ICR mice were studied after respiratory challenge with mouse-adapted preparations of strain A2/Aichi/2/68 influenza virus. Markedly higher doses of virus were required to produce infection with nasopharyngeal challenge than with bronchoalveolar ...

journal_title：Infection and immunity

authors： Larson EW,Dominik JW,Rowberg AH,Higbee GA

更新日期：1976-02-01 00:00:00

abstract：:Mice were infected with Chlamydia trachomatis (L2/434) and at various intervals after infection their lymphoid cells were tested directly for cytotoxic activity against Chlamydia-infected L929 cells. In a modified cell-mediated lympholysis assay, splenic, lymph node, and peritoneal exudate cells did not significantly ...

journal_title：Infection and immunity

authors： Pavia CS,Schachter J

更新日期：1983-03-01 00:00:00

abstract：:Although often considered a strict human pathogen, Streptococcus pneumoniae has been reported to infect and cause pneumonia in horses, although the pathology appears restricted compared to that of human infections. Here we report on the molecular characterization of a group of S. pneumoniae isolates obtained from hors...

journal_title：Infection and immunity

authors： Whatmore AM,King SJ,Doherty NC,Sturgeon D,Chanter N,Dowson CG

更新日期：1999-06-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease, loses its ability to infect and cause disease in mammalian hosts after repeated in vitro passage. To identify proteins preferentially expressed by the low-passage strain and thus representing potential virulence factors, the polypeptide profiles of virulent, l...

journal_title：Infection and immunity

authors： Norris SJ,Carter CJ,Howell JK,Barbour AG

更新日期：1992-11-01 00:00:00

abstract：:Earlier work had shown that a collection of anaerobic bacteria, in conjunction with facultative anaerobes, may be implanted into germfree mice, thereby rendering the animals "normal" with respect to a variety of parameters tested. The present experiments indicate that a different collection of anaerobic bacteria, isol...

journal_title：Infection and immunity

authors： Freter R,Abrams GD

更新日期：1972-08-01 00:00:00

abstract：:The kinetics of cytotoxic T lymphocyte antigen 4 (CTLA-4) expression on T cells responding to Cryptococcus neoformans and its role in regulating the T-cell response were examined. Using peripheral blood mononuclear cells stimulated with encapsulated or acapsular C. neoformans we showed that (i) the encapsulated strain...

journal_title：Infection and immunity

authors： Pietrella D,Perito S,Bistoni F,Vecchiarelli A

更新日期：2001-03-01 00:00:00

abstract：:Mucins are high-molecular-weight glycoproteins and major constituents of the mucus layer which covers the airway surface. We have studied the interactions between bacteria, mucins, and epithelial cells from the human respiratory tract. Nontypeable strains of Haemophilus influenzae were found to bind to purified airway...

journal_title：Infection and immunity

authors： Davies J,Carlstedt I,Nilsson AK,Håkansson A,Sabharwal H,van Alphen L,van Ham M,Svanborg C

更新日期：1995-07-01 00:00:00

abstract：:White-footed mice (Peromyscus leucopus), the primary reservoir for Borrelia burgdorferi in the northern midwest and northeastern United States, were experimentally inoculated with an infectious strain or a noninfectious strain of the Lyme disease spirochete and examined for their specific antibody response with the en...

journal_title：Infection and immunity

authors： Schwan TG,Kime KK,Schrumpf ME,Coe JE,Simpson WJ

更新日期：1989-11-01 00:00:00

abstract：:Chlorphenesin (3-p-chlorophenoxy-1,2-propanediol), when injected intravenously together with either of two common bacterial antigens, inhibits the antibody response of the rabbit. The antigens studied are those common to Enterobacteriaceae and to gram-positive bacteria. The immunosuppression is contingent upon incubat...

journal_title：Infection and immunity

authors： Whang HY,Neter E

更新日期：1970-07-01 00:00:00

abstract：:Ecto-5'-nucleotidase (CD73) is expressed abundantly on the apical surface of intestinal epithelial cells (IECs) and functions as the terminal enzyme in the generation of extracellular adenosine. Previous work demonstrated that adenosine signaling in IECs results in a number of tissue-protective effects during inflamma...

journal_title：Infection and immunity

authors： Kao DJ,Saeedi BJ,Kitzenberg D,Burney KM,Dobrinskikh E,Battista KD,Vázquez-Torres A,Colgan SP,Kominsky DJ

更新日期：2017-09-20 00:00:00

abstract：:Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...

journal_title：Infection and immunity

authors： Moschioni M,Emolo C,Biagini M,Maccari S,Pansegrau W,Donati C,Hilleringmann M,Ferlenghi I,Ruggiero P,Sinisi A,Pizza M,Norais N,Barocchi MA,Masignani V

更新日期：2010-12-01 00:00:00

abstract：:A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and do not inhibit Fn b...

journal_title：Infection and immunity

authors： Huesca M,Sun Q,Peralta R,Shivji GM,Sauder DN,McGavin MJ

更新日期：2000-03-01 00:00:00

abstract：:Resistance against acute and chronic infection with Taxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after in...

journal_title：Infection and immunity

authors： Suzuki Y,Orellana MA,Wong SY,Conley FK,Remington JS

更新日期：1993-06-01 00:00:00

abstract：:The adherence of Treponema denticola GM-1, TD-4, and MS25 to human gingival fibroblasts (HGFs) was studied to serve as an introduction to investigations into the interactions of these oral bacteria with human host cells. Under both aerobic (5% CO2) and anaerobic (85% N2 plus 10% H2 plus 5% CO2) environments, the inter...

journal_title：Infection and immunity

authors： Weinberg A,Holt SC

更新日期：1990-06-01 00:00:00

abstract：:Increased protection against a virulent challenge with Mycobacterium tuberculosis is induced mainly by a previous immunization with living avirulent mycobacteria, usually Mycobacterium bovis BCG. Only a transient and marginal protection is obtained after immunization with bacterial extracts or dead bacteria. Both livi...

journal_title：Infection and immunity

authors： Romain F,Laqueyrerie A,Militzer P,Pescher P,Chavarot P,Lagranderie M,Auregan G,Gheorghiu M,Marchal G

更新日期：1993-02-01 00:00:00

abstract：:The results show that Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium are facultative intracellular bacteria with a capacity to invade and grow in nonphagocytic cells in vivo. In the liver, all of these pathogens were seen to invade and to multiply extensively in hepatocytes. In all three ca...

journal_title：Infection and immunity

authors： Conlan JW,North RJ

更新日期：1992-12-01 00:00:00

abstract：:Dendritic cell interactions with pathogenic microbes initiate and direct the development of subsequent adaptive responses. The protozoan pathogen Giardia lamblia infects the mammalian small intestine, leading to nutrient malabsorption and diarrhea but rarely causing inflammation. In order to begin to understand how th...

journal_title：Infection and immunity

authors： Kamda JD,Singer SM

更新日期：2009-02-01 00:00:00

abstract：:Mycobacterium marinum grows at an optimal temperature of 33 degrees C, far lower than that for M. tuberculosis. Consequently, M. marinum infection of mammals is restricted largely to the cooler surfaces of the body, such as the extremities, but it causes a systemic infection in a large number of poikilothermic animals...

journal_title：Infection and immunity

authors： Ramakrishnan L,Valdivia RH,McKerrow JH,Falkow S

更新日期：1997-02-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF) is thought to play a major role in the pathogenesis of septic shock. Anti-TNF antibody was preadministered in low-dose endotoxin lethality models in which BALB/c mice were challenged with small amounts of lipopolysaccharide following their sensitization with either carrageenan (CAR) o...

journal_title：Infection and immunity

authors： Franks AK,Kujawa KI,Yaffe LJ

更新日期：1991-08-01 00:00:00

abstract：:Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma m...

journal_title：Infection and immunity

authors： Nyindo M,Kariuki TM,Mola PW,Farah IO,Elson L,Blanton RE,King CL

更新日期：1999-02-01 00:00:00