Influenza virus population dynamics in the respiratory tract of experimentally infected mice.

Abstract:

:Virus population dynamics in the lungs, trachea, and nasopharynx of Swiss-ICR mice were studied after respiratory challenge with mouse-adapted preparations of strain A2/Aichi/2/68 influenza virus. Markedly higher doses of virus were required to produce infection with nasopharyngeal challenge than with bronchoalveolar challenge. In all of the infections, the highest virus concentrations were observed in the lungs. Peak concentrations in the trachea were lower than in the lungs but higher than in the nasopharynx. Decreasing virus levels were observed by 120 h after challenge and were generally below detectable levels by the end of 10 days. A compartmental model of a single mathematical form was developed which provided close fits of the virus concentration measurements regardless of the challenge dose, site of initial deposition, or respiratory tissue considered. The model includes seven compartments with five associated rate parameters. The application of compartmental modeling techniques and expression of the virus population dynamics in mathematical terms is regarded as a new approach to the study of the pathogenesis of infections.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Larson EW,Dominik JW,Rowberg AH,Higbee GA

doi

10.1128/IAI.13.2.438-447.1976

keywords:

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

438-47

issue

2

eissn

0019-9567

issn

1098-5522

journal_volume

13

pub_type

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