Abstract:
:Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma mansoni and also develop allergic-type immunity with infection. In one experiment, animals were exposed to a single infection (1,000 cercariae) or were exposed multiple times (100 cercariae per week for 10 weeks) and subsequently were cured with praziquantel prior to challenge with 1, 000 cercariae. Singly and multiply infected animals mounted 59 and 80% reductions in worm burden, respectively (P < 0.01). In a second experiment, animals were inoculated with S. mansoni ova and recombinant human interleukin 12 (IL-12). This produced a 37 to 39% reduction in adult worm burden after challenge (P < 0.05). Parasite-specific IgG, IgE, IgM, and peripheral blood cytokine production were evaluated. The only immune correlate of protection in both experiments was levels of soluble adult worm antigen (SWAP)-specific IgE in serum at the time of challenge infection and/or 6 weeks later. Baboons repeatedly infected with cercariae or immunized with ova and IL-12 developed two- to sixfold-greater levels of SWAP-specific IgE in serum than did controls, and this correlated with reductions in worm burden (r2, -0.40 to -0.64; P, <0. 01). Thus, in baboons and unlike mice, adult worm-specific IgE is uniquely associated with acquired immunity to S. mansoni infection. This similar association of parasite-specific IgE and protection among primates infected with schistosomiasis, along with similar pathology, anatomy, and genetic make-up, indicates that baboons provide an excellent permissive experimental model for better understanding the mechanisms of innate and acquired immunity to schistosomiasis in humans.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Nyindo M,Kariuki TM,Mola PW,Farah IO,Elson L,Blanton RE,King CLdoi
10.1128/IAI.67.2.636-642.1999subject
Has Abstractpub_date
1999-02-01 00:00:00pages
636-42issue
2eissn
0019-9567issn
1098-5522journal_volume
67pub_type
杂志文章abstract::Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this imm...
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journal_title:Infection and immunity
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更新日期:1983-11-01 00:00:00
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doi:10.1128/IAI.61.8.3265-3272.1993
更新日期:1993-08-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1992-12-01 00:00:00
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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更新日期:1994-04-01 00:00:00
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更新日期:1996-10-01 00:00:00
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更新日期:2008-11-01 00:00:00
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更新日期:1979-06-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1995-12-01 00:00:00
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更新日期:2000-11-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1990-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2015-05-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2020-08-19 00:00:00
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更新日期:1997-09-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1998-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-03-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1991-10-01 00:00:00