Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice.

abstract：:Pneumonic plague, caused by inhalation of Yersinia pestis, represents a major bioterrorism threat for which no vaccine is available. Based on the knowledge that genetic delivery of monoclonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antibody expression, we evaluated the...

journal_title：Infection and immunity

authors： Sofer-Podesta C,Ang J,Hackett NR,Senina S,Perlin D,Crystal RG,Boyer JL

更新日期：2009-04-01 00:00:00

abstract：:Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular processes and promote bacterial replication. However, translocated bacterial products are sensed by nucleotide binding domain and leucine-rich repeat-cont...

journal_title：Infection and immunity

authors： Zwack EE,Feeley EM,Burton AR,Hu B,Yamamoto M,Kanneganti TD,Bliska JB,Coers J,Brodsky IE

更新日期：2017-09-20 00:00:00

abstract：:Persistent infection with Borrelia burgdorferi in the presence of a vigorous host immune response has been demonstrated in humans and in animal models of Lyme disease. Long-term persistence of B. burgdorferi was documented recently in our studies of BALB/c and C3H mice infected with cloned and uncloned strains of B. b...

journal_title：Infection and immunity

authors： Persing DH,Mathiesen D,Podzorski D,Barthold SW

更新日期：1994-08-01 00:00:00

abstract：:The acute phase of Chagas' disease is accompanied by immunosuppression. To explore the underlying mechanism(s), we used an in vitro culture system in which the capacities of activated human peripheral blood mononuclear cells to express interleukin-2 receptors (IL-2R) and proliferate are markedly inhibited in the prese...

journal_title：Infection and immunity

authors： Beltz LA,Kierszenbaum F,Sztein MB

更新日期：1989-08-01 00:00:00

abstract：:Chronic actinomycetoma associated with grain production was induced in BALB/c mice by subcutaneous inoculation of live Nocardia brasiliensis in Freund incomplete adjuvant into the hind footpads. Similar inoculation of N. asteroides and N. caviae resulted in local tumor formation which healed spontaneously after 5 mont...

journal_title：Infection and immunity

authors： Zlotnik H,Buckley HR

更新日期：1980-09-01 00:00:00

abstract：:Factors in the queous humor capable of increasing the random migration and chemotaxis of monocytes were demonstrated during experimental uveitis in the rabbit. Injection of endotoxin-free human serum albumin into the vitreous produced a severe inflammation detectable after 7 days and maximal between 12 to 21 days. Aqu...

journal_title：Infection and immunity

authors： Sher NA,Foon KA,Fishman ML,Brown TM

更新日期：1976-04-01 00:00:00

abstract：:We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization ...

journal_title：Infection and immunity

authors： Kodama C,Matsui H

更新日期：2004-04-01 00:00:00

abstract：:Vaccination with native full-length merozoite surface protein 1 (MSP1) or with recombinant C-terminal peptides protects mice against lethal challenge with virulent malaria parasites. To determine whether other regions of MSP1 can also induce protection, Plasmodium yoelii MSP1 was divided into four separate regions. Ea...

journal_title：Infection and immunity

authors： Tian JH,Kumar S,Kaslow DC,Miller LH

更新日期：1997-08-01 00:00:00

abstract：:Cells of Candida albicans strain WO-1 and related strains switch frequently and reversibly between a white-colony-forming unit (white phase) and a gray-colony-forming unit (opaque phase). Cells in the budding white phase exhibit the usual smooth round phenotype observed in other C. albicans strains, but cells in the b...

journal_title：Infection and immunity

authors： Anderson J,Cundiff L,Schnars B,Gao MX,Mackenzie I,Soll DR

更新日期：1989-02-01 00:00:00

abstract：:Exogenous ammonium ions (NH(4) (+)) and amine compounds had a profound influence on the antibacterial activity of the myeloperoxidase-hydrogen peroxide-chloride system against Escherichia coli. The rate of killing increased in the presence of NH(4) (+) and certain guanidino compounds and decreased in the presence of a...

journal_title：Infection and immunity

authors： Thomas EL

更新日期：1979-07-01 00:00:00

abstract：:Culture filtrate proteins from Mycobacterium tuberculosis induce protective immunity in various animal models of tuberculosis. Two molecular mass regions (6 to 10 kDa and 24 to 36 kDa) of short-term culture filtrate are preferentially recognized by Th1 cells in animal models as well as by patients with minimal disease...

journal_title：Infection and immunity

authors： Rosenkrands I,Rasmussen PB,Carnio M,Jacobsen S,Theisen M,Andersen P

更新日期：1998-06-01 00:00:00

abstract：:Sepsis is both a common and, despite present-day therapy, a serious disease. The pathophysiology of the septic response is a complex, multifactorial phenomenon which in part involves the activation of complement by bacterial endotoxin. A monoclonal antibody to human complement factor B, code-named 1H5, which was capab...

journal_title：Infection and immunity

authors： Clardy CW

更新日期：1994-10-01 00:00:00

abstract：:Peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice in the presence of the homologous antigen (heat-killed L. monocytogenes) and normal macrophages showed L. monocytogenes-specific proliferative responses. Proliferation was inhibited by macrophages from L. monocytogenes- or Corynebacterium parvum-...

journal_title：Infection and immunity

authors： Kaufmann SH,Simon MM,Hahn H

更新日期：1982-12-01 00:00:00

abstract：:The lymphogranuloma venereum (LGV) and trachoma biovars of Chlamydia trachomatis exhibit differences in biological properties both in vivo and in vitro. To identify analogous biochemical differences, we studied the molecular charges of chlamydial outer membrane proteins (OMPs) by means of isoelectric focusing and none...

journal_title：Infection and immunity

authors： Batteiger BE,Newhall WJ 5th,Jones RB

更新日期：1985-11-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...

journal_title：Infection and immunity

authors： Adda CG,MacRaild CA,Reiling L,Wycherley K,Boyle MJ,Kienzle V,Masendycz P,Foley M,Beeson JG,Norton RS,Anders RF

更新日期：2012-12-01 00:00:00

abstract：:Phenethyl alcohol, at the maximum concentration which did not inhibit growth (0.3% [vol/vol]), inhibited the production of alpha-lysin and exoproteases but not that of delta-lysin in Staphylococcus aureus Wood 46. The inhibition of alpha-lysin was reversible, and transient accumulation of cell-associated alpha-lysin o...

journal_title：Infection and immunity

authors： Lee KY,Birkbeck TH

更新日期：1985-01-01 00:00:00

abstract：:The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An infection of LPS into mice caused ...

journal_title：Infection and immunity

authors： von Jeney N,Günther E,Jann K

更新日期：1977-01-01 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited high levels of imm...

journal_title：Infection and immunity

authors： Konadu EY,Lin FY,Hó VA,Thuy NT,Van Bay P,Thanh TC,Khiem HB,Trach DD,Karpas AB,Li J,Bryla DA,Robbins JB,Szu SC

更新日期：2000-03-01 00:00:00

abstract：:Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. R...

journal_title：Infection and immunity

authors： Wu JY,Wade WF,Taylor RK

更新日期：2001-12-01 00:00:00

abstract：:Altogether 171 serum specimens from 58 patients with heterophil antibody-positive infectious monomucleosis were studied for antibody response to Epstein-Barr virus (EBV). The sera were tested for fluorescent immunoglobulin G (IgG) and IgM gel-precipitating (GP) and complement-fixing (CF) antibodies to EBV. All 58 pati...

journal_title：Infection and immunity

authors： Nikoskelainen J,Hänninen P

更新日期：1975-01-01 00:00:00

abstract：:Extracytoplasmic proteins were released from Serpulina (Treponema) hyodysenteriae (strain B204) by treatment of whole cells with a nonionic detergent (Tween 20). Centrifugation of the Tween 20-released proteins at 100,000 x g sedimented 10 major extracytoplasmic proteins with approximate molecular masses of 44, 43.5, ...

journal_title：Infection and immunity

authors： Gabe JD,Chang RJ,Slomiany R,Andrews WH,McCaman MT

更新日期：1995-01-01 00:00:00

abstract：:Several group B streptococcal products have been previously found to stimulate human monocytes to produce tumor necrosis factor alpha. In order to identify the receptors involved in these responses, monocytes were stimulated with purified group- or type-specific carbohydrates or lipoteichoic acid in the presence of an...

journal_title：Infection and immunity

authors： Cuzzola M,Mancuso G,Beninati C,Biondo C,von Hunolstein C,Orefici G,Espevik T,Flo TH,Teti G

更新日期：2000-02-01 00:00:00

abstract：:Carbon storage regulator A (CsrA) is an RNA binding protein that has been characterized in many bacterial species to play a central regulatory role by modulating several metabolic processes. We recently showed that a homolog of CsrA in Borrelia burgdorferi (CsrA(Bb), BB0184) was upregulated in response to propagation ...

journal_title：Infection and immunity

authors： Karna SL,Sanjuan E,Esteve-Gassent MD,Miller CL,Maruskova M,Seshu J

更新日期：2011-02-01 00:00:00

abstract：:Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico str...

journal_title：Infection and immunity

authors： Suarez CE,McElwain TF,Echaide I,Torioni de Echaide S,Palmer GH

更新日期：1994-08-01 00:00:00

abstract：:The effect of ingestion of heat-killed Histoplasma capsulatum yeast cells on the metabolism of arachidonic acid (20:4) to prostenoids and leukotrienes was examined in murine peritoneal macrophages (M phi s). H. capsulatum-containing M phi s exhibited a metabolite profile similar to that of zymosan-challenged phagocyte...

journal_title：Infection and immunity

authors： Wolf JE,Massof SE,Peters SP

更新日期：1992-07-01 00:00:00

abstract：:Candida albicans is a common opportunistic fungal pathogen and is the leading cause of invasive fungal diseases in immunocompromised individuals. The induction of cell-mediated immunity to C. albicans is one of the main tasks of cells of the innate immune system, and in vitro evidence suggests that integrin α(M)β₂ (CR...

journal_title：Infection and immunity

authors： Soloviev DA,Jawhara S,Fonzi WA

更新日期：2011-04-01 00:00:00

abstract：:Helicobacter pylori infection causes severe gastroduodenal diseases in humans. Its virulence is strongly increased by the presence of the cag pathogenicity island (cag PAI). It has been shown that CagA, a major antigen in humans, is translocated to the host cell via a secretion system encoded by the cag PAI. The roles...

journal_title：Infection and immunity

authors： Seydel A,Tasca E,Berti D,Rappuoli R,Del Giudice G,Montecucco C

更新日期：2002-11-01 00:00:00

abstract：:The distribution of dengue-2 antigens was studied in infected monkey kidney cells (LLC MK2) using an indirect, horseradish peroxidase-conjugated immunoglobulin technique. This procedure allowed both light and electron microscopic examination of serial-step sections of individual cells cut in a plane perpendicular to t...

journal_title：Infection and immunity

authors： Cardiff RD,Lund JK

更新日期：1976-06-01 00:00:00

abstract：:Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings ...

journal_title：Infection and immunity

authors： Ando M,Suga M,Shima K,Sugimoto M,Tokuomi H

更新日期：1978-05-01 00:00:00

abstract：:The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with ...

journal_title：Infection and immunity

authors： Morton DJ,Musser JM,Stull TL

更新日期：1993-10-01 00:00:00