Differences in outer membrane proteins of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis.

abstract：:A plaque assay system for pathogenic rickettsiae, which utilizes primary chick embryo tissue cultures, is described. It proved to be a highly reproducible measure of infectiousness for Rickettsia rickettsi and R. typhi, which were employed in most studies; as well as for R. canada, R. prowazeki, R. sibirica, R. akari,...

journal_title：Infection and immunity

authors： Wike DA,Tallent G,Peacock MG,Ormsbee RA

更新日期：1972-05-01 00:00:00

abstract：:Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity. ...

journal_title：Infection and immunity

authors： Schlievert PM,Schoettle DJ,Watson DW

更新日期：1979-09-01 00:00:00

abstract：:Detailed structural studies were undertaken on five isolates of bovine rotavirus which showed variability in the migration patterns of their genome segments on electrophoresis in polyacrylamide gels. The individual genome segments of each isolate were characterized by partial digestion of terminally radiolabeled RNA w...

journal_title：Infection and immunity

authors： Clarke IN,McCrae MA

更新日期：1982-05-01 00:00:00

abstract：:Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific ep...

journal_title：Infection and immunity

authors： Batteiger BE,Lin PM,Jones RB,Van Der Pol BJ

更新日期：1996-07-01 00:00:00

abstract：:Streptococcus pneumoniae is a frequent colonizer of the upper respiratory tract and a leading cause of bacterial pneumonia. The innate immune system senses pneumococcal cell wall components, toxin, and nucleic acids, which leads to production of inflammatory mediators to initiate and control antibacterial defense. Her...

journal_title：Infection and immunity

authors： Ruiz-Moreno JS,Hamann L,Jin L,Sander LE,Puzianowska-Kuznicka M,Cambier J,Witzenrath M,Schumann RR,Suttorp N,Opitz B

更新日期：2018-02-20 00:00:00

abstract：:Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC). Involvement of P. gingivalis fimbriae in the invasion process was examined. Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent m...

journal_title：Infection and immunity

authors： Weinberg A,Belton CM,Park Y,Lamont RJ

更新日期：1997-01-01 00:00:00

abstract：:Routine culture of endothelial cells currently includes the use of heparin, which significantly reduces cell doubling time and increases cell population size. Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites produced by the action of xanthine and xanthine oxidase. Because of...

journal_title：Infection and immunity

authors： Silverman DJ,Santucci LA,Sekeyova Z

更新日期：1991-12-01 00:00:00

abstract：:The lipid A portion has been identified as the active center responsible for lipopolysaccharide (LPS)-induced macrophage activation. However, we found that Salmonella (Salmonella enterica serovars Abortusequi, Minnesota, and Typhimurium) lipid A is inactive in human macrophages, despite its LPS being highly active. Th...

journal_title：Infection and immunity

authors： Muroi M,Tanamoto K

更新日期：2002-11-01 00:00:00

abstract：:Brucella spp. are gram-negative intracellular pathogens that survive and multiply within phagocytic cells of their hosts. Smooth organisms present O polysaccharides (OPS) on their surface. These OPS help the bacteria avoid the bactericidal action of serum. The wboA gene, coding for the enzyme glycosyltransferase, is e...

journal_title：Infection and immunity

authors： Fernandez-Prada CM,Nikolich M,Vemulapalli R,Sriranganathan N,Boyle SM,Schurig GG,Hadfield TL,Hoover DL

更新日期：2001-07-01 00:00:00

abstract：:Previous studies have demonstrated that both Ixodes scapularis saliva and Borrelia burgdorferi antigens modulated lymphokines and monokines in vitro. The studies presented here were designed to delineate the role of I. scapularis and B. burgdorferi in modulation of the host immune response in vivo. Infestation of C3H/...

journal_title：Infection and immunity

authors： Zeidner N,Mbow ML,Dolan M,Massung R,Baca E,Piesman J

更新日期：1997-08-01 00:00:00

abstract：:The mechanisms linking the immune response to cutaneous and mucosal leishmaniasis (CL and ML, respectively) lesions and the response to treatment are incompletely understood. Our aims were to prospectively assess, by quantitative reverse transcription-PCR, the levels of mRNA for gamma interferon, tumor necrosis factor...

journal_title：Infection and immunity

authors： Maurer-Cecchini A,Decuypere S,Chappuis F,Alexandrenne C,De Doncker S,Boelaert M,Dujardin JC,Loutan L,Dayer JM,Tulliano G,Arevalo J,Llanos-Cuentas A,Chizzolini C

更新日期：2009-05-01 00:00:00

abstract：:Akabane virus (a Bunyavirus) has been associated with epizootics of congenital deformities in cattle, sheep, and goats. Experimental studies using mouse-adapted virus inoculated intravenously into pregnant sheep gave an inapparent infection. Neutralizing antibodies were detected on day 5, and peaks in the titer were s...

journal_title：Infection and immunity

authors： Parsonson IM,Della-Porta AJ,Snowdon WA

更新日期：1977-01-01 00:00:00

abstract：:Glycosylphosphatidylinositol (GPI)-anchored proteins are abundantly expressed in the infective and intracellular stages of Trypanosoma cruzi and are recognized as antigenic targets by both the humoral and cellular arms of the immune system. Previously, we demonstrated the efficacy of genes encoding GPI-anchored protei...

journal_title：Infection and immunity

authors： Bhatia V,Sinha M,Luxon B,Garg N

更新日期：2004-11-01 00:00:00

abstract：:Gram-negative bacterial cells exposed to a complement source may carry membrane attack complexes containing variable numbers of C9 molecules per C5b-8 site. In order to investigate the assembly of this complex, the ability of C9 molecules to bind to C5b-8 complexes was compared with the binding characteristics of C9 f...

journal_title：Infection and immunity

authors： MacKay SL,Dankert JR

更新日期：1994-07-01 00:00:00

abstract：:The adjuvant action of various lipopolysaccharides on immune responses to syngeneic tissue extract in mice was examined. Only lipopolysaccharides possessing the linear mannose homopolysaccharides as O-specific polysaccharides exhibited definite adjuvant action on immune responses to the autoantigens. The intensity of ...

journal_title：Infection and immunity

authors： Yokochi T,Fukada M,Kawai M,Zhang YH,Jiang GZ,Takahashi K

更新日期：1992-11-01 00:00:00

abstract：:Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...

journal_title：Infection and immunity

authors： Babb K,El-Hage N,Miller JC,Carroll JA,Stevenson B

更新日期：2001-06-01 00:00:00

abstract：:A parasitic protozoan, Leishmania mexicana amazonensis, was previously made resistant to tunicamycin (J.A. Kink and K.-P. Chang, Proc. Natl. Acad. Sci. USA 84:1253-1257, 1987). In the present study, six different tunicamycin-resistant variants were biologically and biochemically compared with their parental wild type ...

journal_title：Infection and immunity

authors： Kink JA,Chang KP

更新日期：1987-07-01 00:00:00

abstract：:Sporothrix schenckii is a human pathogen that causes sporotrichosis, an important cutaneous mycosis with a worldwide distribution. It produces dark-brown conidia, which infect the host. We found that S. schenckii synthesizes melanin via the 1,8-dihydroxynaphthalene pentaketide pathway. Melanin biosynthesis in the wild...

journal_title：Infection and immunity

authors： Romero-Martinez R,Wheeler M,Guerrero-Plata A,Rico G,Torres-Guerrero H

更新日期：2000-06-01 00:00:00

abstract：:Infection with Cryptosporidium parvum, a ubiquitous protozoan parasite of virtually all mammals, can cause mild to severe diarrhea in immunocompetent hosts and life-threatening diarrhea in immunocompromised hosts. Passive immunotherapy of experimentally infected animals and naturally infected humans with hyperimmune b...

journal_title：Infection and immunity

authors： Fayer R,Guidry A,Blagburn BL

更新日期：1990-09-01 00:00:00

abstract：:Neutrophil serine proteases cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 (PR3) have recently been shown to contribute to killing of Streptococcus pneumoniae in vitro. However, their relevance in lung-protective immunity against different serotypes of S. pneumoniae in vivo has not been determined so far...

journal_title：Infection and immunity

authors： Hahn I,Klaus A,Janze AK,Steinwede K,Ding N,Bohling J,Brumshagen C,Serrano H,Gauthier F,Paton JC,Welte T,Maus UA

更新日期：2011-12-01 00:00:00

abstract：:A Mycoplasma pneumoniae cytadhesin P1 gene with novel nucleotide sequence variation has been identified. Four clinical strains of M. pneumoniae were found to carry this type of P1 gene. This new P1 gene is similar to the known group II P1 genes but possesses novel sequence variation of approximately 300 bp in the RepM...

journal_title：Infection and immunity

authors： Kenri T,Taniguchi R,Sasaki Y,Okazaki N,Narita M,Izumikawa K,Umetsu M,Sasaki T

更新日期：1999-09-01 00:00:00

abstract：:Streptococcal pyrogenic exotoxin B (SpeB), a conserved cysteine protease expressed by virtually all Streptococcus pyogenes strains, has recently been shown to be an important virulence factor (S. Lukomski, S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J. M. Musser, J. Clin. Invest. 99:2574-2...

journal_title：Infection and immunity

authors： Lukomski S,Burns EH Jr,Wyde PR,Podbielski A,Rurangirwa J,Moore-Poveda DK,Musser JM

更新日期：1998-02-01 00:00:00

abstract：:Mycoplasma arthritidis induces an acute to chronic arthritis in rodents. Arthritis induced in mice histologically resembles human rheumatoid arthritis and can be associated with lethal toxicity following systemic injection. The M. arthritidis mitogen (MAM) superantigen has long been implicated as having a role in path...

journal_title：Infection and immunity

authors： Luo W,Yu H,Cao Z,Schoeb TR,Marron M,Dybvig K

更新日期：2008-11-01 00:00:00

abstract：:The development of chronic pathology in mice at 2 to 10 months after inoculation of 10(2) T. cruzi trypomastigotes can be prevented by preimmunization with live, attenuated culture parasites (strain TCC). Swiss mice received one or three immunizing inoculations of 10(6) TCC organisms and were challenged with 10(2) Tul...

journal_title：Infection and immunity

authors： Basombrío MA,Besuschio S

更新日期：1982-04-01 00:00:00

abstract：:The bacterial pathogen Clostridium difficle synthesizes two high-molecular-weight toxins (A and B), which exhibit toxic effects in vivo and in vitro. Here, we present evidence that the major intracellular targets of these two toxins are the Rho GTPases. Overexpression of RhoA, RhoB, or RhoC GTPases in transfected HeLa...

journal_title：Infection and immunity

authors： Giry M,Popoff MR,von Eichel-Streiber C,Boquet P

更新日期：1995-10-01 00:00:00

abstract：:An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular ...

journal_title：Infection and immunity

authors： Murphy JR,Grez L,Schlesinger L,Ferreccio C,Baqar S,Muñoz C,Wasserman SS,Losonsky G,Olson JG,Levine MM

更新日期：1991-11-01 00:00:00

abstract：:Athymic BALB/c nude mice and euthymic BALB/c mice were infected with Rickettsia akari by the intraperitoneal route. The rickettsialpox infection was terminated in euthymic mice with only two intraperitoneal injections of the antibiotic oxytetracycline, whereas prolonged treatment was necessary to terminate the infecti...

journal_title：Infection and immunity

authors： Kenyon RH,Pedersen CE Jr

更新日期：1980-05-01 00:00:00

abstract：:G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobial sepsis-induced inflammation. The goal of the present study was to examine the role of GRK5 in monomicrobial pulmonary infection by using an intratracheal Escherichia coli infection model of pneumonia. We u...

journal_title：Infection and immunity

authors： Packiriswamy N,Steury M,McCabe IC,Fitzgerald SD,Parameswaran N

更新日期：2016-04-22 00:00:00

abstract：:The antigenically variant Chlamydia trachomatis major outer membrane protein (MOMP) is a target of antibody-mediated neutralization in vitro, and it is an important protein for designing a subunit vaccine. Knowledge of MOMP T-cell determinants will be essential to elicit rapid and strong immune responses following an ...

journal_title：Infection and immunity

authors： Ishizaki M,Allen JE,Beatty PR,Stephens RS

更新日期：1992-09-01 00:00:00

abstract：:Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Even though IFN-gamma was produced upon exposure of LGL to bacteria, anti-IFN-gamma antibodies failed to interfere with induction of c...

journal_title：Infection and immunity

authors： Tarkkanen J,Saksela E

更新日期：1991-08-01 00:00:00