Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences.

abstract：:Toll-like receptor (TLR) signal transduction is a central component of the innate immune response to pathogenic challenge. Although recent studies have begun to elucidate differences in acquired immunity in tissues of the human female reproductive tract, there is a relative paucity of work regarding innate defense mec...

journal_title：Infection and immunity

authors： Pioli PA,Amiel E,Schaefer TM,Connolly JE,Wira CR,Guyre PM

更新日期：2004-10-01 00:00:00

abstract：:Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vu...

journal_title：Infection and immunity

authors： Merkel SM,Alexander S,Zufall E,Oliver JD,Huet-Hudson YM

更新日期：2001-10-01 00:00:00

abstract：:Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

journal_title：Infection and immunity

authors： Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

更新日期：2000-02-01 00:00:00

abstract：:A hamster immunization challenge assay described in the accompanying paper (M. F. Barile, D. K. F. Chandler, H. Yoshida, M. W. Grabowski, R. Harasawa, and S. Razin, Infect. Immun. 56:2443-2449, 1988) was used to examine protection against Mycoplasma pneumoniae disease by passive immunization and to evaluate the protec...

journal_title：Infection and immunity

authors： Barile MF,Chandler DK,Yoshida H,Grabowski MW,Razin S

更新日期：1988-09-01 00:00:00

abstract：:Mice immunized intravenously 10 days earlier (but not those immunized 2 months earlier) with an attenuated Salmonella typhimurium SL3261 aroA live vaccine and tested for delayed-type hypersensitivity by injection of crude Salmonella extracts in the footpad can die within 24 to 48 h of an unexplained allergic reaction....

journal_title：Infection and immunity

authors： Mastroeni P,Villarreal-Ramos B,Harrison JA,Demarco de Hormaeche R,Hormaeche CE

更新日期：1994-06-01 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:Streptococcus pneumoniae is a frequent colonizer of the upper respiratory tract and a leading cause of bacterial pneumonia. The innate immune system senses pneumococcal cell wall components, toxin, and nucleic acids, which leads to production of inflammatory mediators to initiate and control antibacterial defense. Her...

journal_title：Infection and immunity

authors： Ruiz-Moreno JS,Hamann L,Jin L,Sander LE,Puzianowska-Kuznicka M,Cambier J,Witzenrath M,Schumann RR,Suttorp N,Opitz B

更新日期：2018-02-20 00:00:00

abstract：:Ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of Mycobacterium leprae.BALB/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days aft...

journal_title：Infection and immunity

authors： Evans MJ,Levy L

更新日期：1972-02-01 00:00:00

abstract：:We assessed cell-mediated immunity to herpes simplex virus type 1 antigen in patients suffering from recurrent cold sores and in a series of healthy controls. Paradoxically, all those subject to recurrent herpetic infections had, without exception, evidence of cell-mediated immunity to herpes antigens. This was demons...

journal_title：Infection and immunity

authors： Russell AS,Percy JS,Kovithavongs T

更新日期：1975-02-01 00:00:00

abstract：:Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...

journal_title：Infection and immunity

authors： Watanabe T,Shibata K,Hasegawa K

更新日期：1987-01-01 00:00:00

abstract：:Macrophages are among the most sensitive targets of bacterial endotoxin (LPS), responding to minute amounts of LPS by releasing a battery of inflammatory mediators. Transfection of macrophages with secretory leukocyte protease inhibitor (SLPI) renders these cells refractory to LPS stimulation. Here we show that uptake...

journal_title：Infection and immunity

authors： Ding A,Thieblemont N,Zhu J,Jin F,Zhang J,Wright S

更新日期：1999-09-01 00:00:00

abstract：:A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demo...

journal_title：Infection and immunity

authors： Murphy GL,Whitworth LC,Clinkenbeard KD,Clinkenbeard PA

更新日期：1995-08-01 00:00:00

abstract：:Inactivation of sortase gene srtA in Streptococcus pneumoniae strain R6 caused the release of beta-galactosidase and neuraminidase A (NanA) from the cell wall into the surrounding medium. Both of these surface proteins contain the LPXTG motif in the C-terminal domain. Complementation with plasmid-borne srtA reversed p...

journal_title：Infection and immunity

authors： Kharat AS,Tomasz A

更新日期：2003-05-01 00:00:00

abstract：:Enterococcus faecalis strains are resident intestinal bacteria associated with invasive infections, inflammatory bowel diseases, and colon cancer. Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in E. faecalis strain OG1...

journal_title：Infection and immunity

authors： Fan TJ,Goeser L,Naziripour A,Redinbo MR,Hansen JJ

更新日期：2019-06-20 00:00:00

abstract：:Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...

journal_title：Infection and immunity

authors： Clark S,Cross ML,Nadian A,Vipond J,Court P,Williams A,Hewinson RG,Aldwell FE,Chambers MA

更新日期：2008-08-01 00:00:00

abstract：:Since we previously observed a remarkable decrease in the numbers of T cells in the Peyer's patches of the small intestines in C57BL/6 mice following peroral infection with Toxoplasma gondii, we performed studies to examine the mechanism(s) whereby this decrease in numbers of the T cells occurs. We found that apoptoti...

journal_title：Infection and immunity

authors： Liesenfeld O,Kosek JC,Suzuki Y

更新日期：1997-11-01 00:00:00

abstract：:The stimulation of mononuclear phagocytes by lipopolysaccharide (LPS) is facilitated by the binding of complexes of LPS and LPS-binding protein to CD14. Although it is clear that CD14 is involved in LPS-induced signaling, other investigators have hypothesized the existence of additional signaling pathways in macrophag...

journal_title：Infection and immunity

authors： Lynn WA,Liu Y,Golenbock DT

更新日期：1993-10-01 00:00:00

abstract：:We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg and 0.1 mg zymosan intra-articularly (i.a.). Test groups received an A. suum extract either per os (p.o.) or intraperitoneally (i.p....

journal_title：Infection and immunity

authors： Rocha FA,Leite AK,Pompeu MM,Cunha TM,Verri WA Jr,Soares FM,Castro RR,Cunha FQ

更新日期：2008-06-01 00:00:00

abstract：:Pseudomonas aeruginosa elastase rapidly inactivates alpha 1-proteinase inhibitor by splitting its Pro-357-Met-358 peptide bond. The present study was aimed at testing whether this reaction takes place in the presence of leukocyte elastase. To this end was added alpha 1-proteinase inhibitor to a mixture of the two elas...

journal_title：Infection and immunity

authors： Padrines M,Bieth JG

更新日期：1989-12-01 00:00:00

abstract：:Mammalian hosts often develop distinct immune response against the diverse parasitic helminths that have evolved for immune evasion. Interleukin-25 (IL-25), an IL-17 cytokine family member, plays a key role in initiating the protective immunity against several parasitic helminths; however, the involvement and underlyi...

journal_title：Infection and immunity

authors： Angkasekwinai P,Srimanote P,Wang YH,Pootong A,Sakolvaree Y,Pattanapanyasat K,Chaicumpa W,Chaiyaroj S,Dong C

更新日期：2013-10-01 00:00:00

abstract：:Infection with Giardia duodenalis is one of the most common causes of diarrheal disease in the world. While numerous studies have identified important contributions of adaptive immune responses to parasite control, much less work has examined innate immunity and its connections to the adaptive response during this inf...

journal_title：Infection and immunity

authors： Li E,Tako EA,Singer SM

更新日期：2016-03-24 00:00:00

abstract：:Murine cerebral malaria (CM) induced by Plasmodium berghei ANKA kills susceptible mice within 24 to 48 h of onset of symptoms and is characterized by the production of inflammatory cytokines in the brain. C57BL/6J mice are sensitive to lethal CM, while A/J mice are resistant. These strains of mice were immunized with ...

journal_title：Infection and immunity

authors： Jennings VM,Lal AA,Hunter RL

更新日期：1998-12-01 00:00:00

abstract：:The short-term kinetics of fluoride uptake by cells from 20- to 22-h cultures of Streptococcus mutans strain 6715 were studied using rapid filtration and centrifugation techniques. Saline-suspended organisms were diluted with fluoride-containing solutions buffered at four different pH values (2.0, 4.0, 5.5, and 8.2). ...

journal_title：Infection and immunity

authors： Whitford GM,Schuster GS,Pashley DH,Venkateswarlu P

更新日期：1977-12-01 00:00:00

abstract：:The adherence of 58 nontypeable Haemophilus influenzae isolates obtained from patients with otitis media or chronic obstructive pulmonary disease (COPD) and obtained from the throats of healthy individuals to Chang and NCI-H292 epithelial cells was compared. Otitis media isolates, but not COPD isolates, adhered signif...

journal_title：Infection and immunity

authors： van Schilfgaarde M,van Ulsen P,Eijk P,Brand M,Stam M,Kouame J,van Alphen L,Dankert J

更新日期：2000-08-01 00:00:00

abstract：:A better knowledge on how immune responses are initiated in mucosal tissues would facilitate the design of new mucosal vaccines, as well as improve our understanding on host defense against infection. We investigated the mechanisms of adjuvanticity of the Mycoplasma-derived macrophage-activating 2-kDa lipopeptide (MAL...

journal_title：Infection and immunity

authors： Rharbaoui F,Westendorf A,Link C,Felk S,Buer J,Gunzer M,Guzmán CA

更新日期：2004-12-01 00:00:00

abstract：:Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...

journal_title：Infection and immunity

authors： Thore M,Löfgren S,Tärnvik A,Monsen T,Selstam E,Burman LG

更新日期：1985-01-01 00:00:00

abstract：:A novel in vivo expression technology (IVET) was performed to identify Klebsiella pneumoniae CG43 genes that are specifically expressed during infection of BALB/c mice. The IVET employed a UDP glucose pyrophosphorylase (galU)-deficient mutant of K. pneumoniae which is incapable of utilizing galactose and synthesizing ...

journal_title：Infection and immunity

authors： Lai YC,Peng HL,Chang HY

更新日期：2001-11-01 00:00:00

abstract：:An antigenic complex has been isolated in a highly purified from from the Melvin strain of Neisseria gonorrhoeae. The complex has a molecular weight of 9.3 x 10(6) and on sodium dodecyl sulfate-polyacrylamide gel electrophoresis was found to consist of several subunits; the most predominant had the following molecular...

journal_title：Infection and immunity

authors： Karkhanis YD,Anderson RL,Zeltner JY,Carlo DJ,Stoudt TH

更新日期：1979-08-01 00:00:00

abstract：:In contrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be associated with a significantly diminished inflammatory response, suggesting that this bacterium has the ability to both promote and suppress inflammation. To examine this, we analyzed the behavior of an S. pyogen...

journal_title：Infection and immunity

authors： Lin A,Loughman JA,Zinselmeyer BH,Miller MJ,Caparon MG

更新日期：2009-11-01 00:00:00

abstract：:The role of the spleen in hepatic amoebiasis in hamsters was studied. In hamsters receiving an intrahepatic inoculation of 10(5) trophozoites of axenic Entamoeba histolytica at 7 or 14 days postsplenectomy, the mean weight of metastatic foci increased significantly when compared with sham-splenectomized or intact cont...

journal_title：Infection and immunity

authors： Ghadirian E,Meerovitch E

更新日期：1981-02-01 00:00:00