T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis.

abstract：:This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo...

journal_title：Infection and immunity

authors： Hörnqvist E,Goldschmidt TJ,Holmdahl R,Lycke N

更新日期：1991-10-01 00:00:00

abstract：:Mutant analysis was used to identify Moraxella catarrhalis gene products necessary for biofilm development in a crystal violet-based assay involving 24-well tissue culture plates. The wild-type M. catarrhalis strains that formed the most extensive biofilms in this system proved to be refractory to transposon mutagenes...

journal_title：Infection and immunity

authors： Pearson MM,Laurence CA,Guinn SE,Hansen EJ

更新日期：2006-03-01 00:00:00

abstract：:Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incuba...

journal_title：Infection and immunity

authors： Casanova M,Martínez JP,Chaffin WL

更新日期：1990-11-01 00:00:00

abstract：:Rubella virus was capable of replicating in both unstimulated and phytohemagglutinin-stimulated cultures of human mononuclear blood cells. Monocyte-derived macrophages were the main cell type responsible for viral replication. The susceptibility of macrophages increased during cultivation. Phytohemagglutinin-stimulate...

journal_title：Infection and immunity

authors： van der Logt JT,van Loon AM,van der Veen J

更新日期：1980-02-01 00:00:00

abstract：:Advanced human periodontitis is considered to be a B-cell lesion, but the cellular infiltrate contains several cell types, the distribution of which has not been determined. This experiment was designed to characterize and identify the immunocompetent cells on histological sections and in eluates from diseased human g...

journal_title：Infection and immunity

authors： Okada H,Kida T,Yamagami H

更新日期：1983-07-01 00:00:00

abstract：:The adherence of several strains of Escherichia coli to human buccal epithelial cells was studied, using cells obtained from five groups: healthy adults, healthy children, children with acute diarrhea, children with persistent diarrhea associated with cryptosporidial parasites, and children with noncryptosporidial per...

journal_title：Infection and immunity

authors： Walser BL,Newman RD,Lima AA,Guerrant RL

更新日期：1992-11-01 00:00:00

abstract：:Neisseria gonorrhoeae enters cultured human mucosal cells following binding of a distinct gonococcal opacity (Opa) outer membrane protein to cell surface proteoglycan receptors. We examined the route of internalization that is activated by Opa-expressing gonococci (strain VP1). Microscopy of infected Chang epithelial ...

journal_title：Infection and immunity

authors： Grassmé HU,Ireland RM,van Putten JP

更新日期：1996-05-01 00:00:00

abstract：:Vibrio cholerae, the pathogen that causes cholera, also survives in aqueous reservoirs, probably in the form of biofilms. Quorum sensing negatively regulates V. cholerae biofilm formation through HapR, whose expression is induced at a high cell density. In this study, we show that the concentration of the quorum-sensi...

journal_title：Infection and immunity

authors： Liu Z,Stirling FR,Zhu J

更新日期：2007-01-01 00:00:00

abstract：:Infection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by high levels of inflammatory cytokines and a high mortality rate. Our previous study indicated that TREM-1 (triggering receptor expressed on myeloid cells 1) was upregulated in swine spleen cells in response to S. suis...

journal_title：Infection and immunity

authors： Yang C,Chen B,Zhao J,Lin L,Han L,Pan S,Fu L,Jin M,Chen H,Zhang A

更新日期：2015-08-01 00:00:00

abstract：:The tetrasaccharide 3-deoxy-alpha-D-manno-2-octulosonic acid (alpha-KDO) (2----8)-alpha-KDO(2----4)-alpha-KDO(2----6)-beta GlcNAc, a partial structure of chlamydial lipopolysaccharide (LPS) representing a genus-specific epitope, was synthesized and covalently linked to bovine serum albumin, resulting in an artificial ...

journal_title：Infection and immunity

authors： Fu Y,Baumann M,Kosma P,Brade L,Brade H

更新日期：1992-04-01 00:00:00

abstract：:In an attempt to clarify the mechanism(s) of increased susceptibility to oral infection in diabetics, we examined the levels of salivary antibacterial factors, including lysozyme, lactoperoxidase, and lactoferrin, in diabetic hamsters whose condition was induced with streptozotocin. Saliva was collected from these ham...

journal_title：Infection and immunity

authors： Muratsu K,Morioka T

更新日期：1985-05-01 00:00:00

abstract：:Ultrastructural immunoperoxidase studies were done in spinal cords of mice infected with wild type vesicular stomatitis virus or its temperature-sensitive (ts) mutant G31. Infected neurons showed subplasmalemmal staining of viral antigen and staining of viral particles budding from the neuronal membrane in wild-type v...

journal_title：Infection and immunity

authors： Dal Canto MC,Rabinowitz SG,Johnson TC,Hughes JV

更新日期：1979-04-01 00:00:00

abstract：:Strains of Bacteroides fragilis associated with diarrhea in children (termed enterotoxigenic B. fragilis, or ETBF) produce a heat-labile ca. 20-kDa protein toxin (BFT). The purpose of this study was to examine the activity of BFT on polarized monolayers of human intestinal epithelial cells (T84 cells). In Ussing chamb...

journal_title：Infection and immunity

authors： Chambers FG,Koshy SS,Saidi RF,Clark DP,Moore RD,Sears CL

更新日期：1997-09-01 00:00:00

abstract：:Alveolar macrophages are the effector cells largely responsible for clearance of Pneumocystis carinii from the lungs. Binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytosis of the organisms. To further define the mechanisms used by alveolar macrophages for clearance of P. ca...

journal_title：Infection and immunity

authors： Hollifield M,Bou Ghanem E,de Villiers WJ,Garvy BA

更新日期：2007-08-01 00:00:00

abstract：:This study determined the role of crl in the production of curli by, the hemagglutination activity of, and fibronectin binding by avian pathogenic Escherichia coli chi 7122. Curli, an extracellular structure that binds fibronectin, was recently described (A. Olsén, A. Jonsson, and S. Normark, Nature [London] 338:652-6...

journal_title：Infection and immunity

authors： Provence DL,Curtiss R 3rd

更新日期：1992-11-01 00:00:00

abstract：:Variable subregions within the variant surface glycoprotein (VSG) coat displayed by African trypanosomes are predicted sites for T- and B-cell recognition. Hypervariable subregion 1 (HV-1) is localized to an internal amphipathic alpha helix in VSG monomers and may have evolved due to selective pressure by host T-cell ...

journal_title：Infection and immunity

authors： Dagenais TR,Demick KP,Bangs JD,Forest KT,Paulnock DM,Mansfield JM

更新日期：2009-01-01 00:00:00

abstract：:The effect of ingestion of heat-killed Histoplasma capsulatum yeast cells on the metabolism of arachidonic acid (20:4) to prostenoids and leukotrienes was examined in murine peritoneal macrophages (M phi s). H. capsulatum-containing M phi s exhibited a metabolite profile similar to that of zymosan-challenged phagocyte...

journal_title：Infection and immunity

authors： Wolf JE,Massof SE,Peters SP

更新日期：1992-07-01 00:00:00

abstract：:Wild-type Bordetella bronchiseptica and a bvg mutant strain were used for invasion and survival experiments in human Caco-2 and A549 epithelial cells. Both bacterial strains were able to enter and persist within the host cells for at least a week. A significant proportion of the bacteria from both B. bronchiseptica st...

journal_title：Infection and immunity

authors： Schipper H,Krohne GF,Gross R

更新日期：1994-07-01 00:00:00

abstract：:The attachment of isogenic fimbriated and nonfimbriated Haemophilus influenzae type b variants to human cells was studied by using a radioactive assay and an indirect immunofluorescent assay. As described previously, fimbriated H. influenzae variants adhered to a greater extent than nonfimbriated variants to human buc...

journal_title：Infection and immunity

authors： Sable NS,Connor EM,Hall CB,Loeb MR

更新日期：1985-04-01 00:00:00

abstract：:The interaction of plasma fibronectin with C1q of the complement system has been demonstrated in the past several years. In addition, the antibody-independent binding of C1q to bacteria, as well as the binding of plasma fibronectin to bacteria, is well documented. This study examines whether the binding of C1q to bact...

journal_title：Infection and immunity

authors： Sorvillo JM,Pearlstein E

更新日期：1985-09-01 00:00:00

abstract：:The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American...

journal_title：Infection and immunity

authors： Restrepo-Moreno A

更新日期：1970-09-01 00:00:00

abstract：:Identification of antigenically conserved surface components of Haemophilus ducreyi may facilitate the development of reagents to diagnose and prevent chancroid. A hybridoma derived from a mouse immunized with nontypeable Haemophilus influenzae produced a monoclonal antibody (MAb), designated 3B9, that bound to 35 of ...

journal_title：Infection and immunity

authors： Spinola SM,Griffiths GE,Bogdan J,Menegus MA

更新日期：1992-02-01 00:00:00

abstract：:The Escherichia coli genome varies in size from 4.5 to 5.5 Mb. It is unclear whether this variation may be distributed finely throughout the genome or is concentrated at just a few chromosomal loci or on plasmids. Further, the functional correlates of size variation in different genome copies are largely unexplored. W...

journal_title：Infection and immunity

authors： Rode CK,Melkerson-Watson LJ,Johnson AT,Bloch CA

更新日期：1999-01-01 00:00:00

abstract：:Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. Th...

journal_title：Infection and immunity

authors： Fux B,Rodrigues CV,Portela RW,Silva NM,Su C,Sibley D,Vitor RW,Gazzinelli RT

更新日期：2003-11-01 00:00:00

abstract：:Two virulence factors of Listeria monocytogenes, listeriolysin O (LLO) and phosphatidylinositol-specific phospholipase C (PI-PLC), mediate escape of this pathogen from the phagocytic vacuole of macrophages, thereby allowing the bacterium access to the host cell cytosol for growth and spread to neighboring cells. We ch...

journal_title：Infection and immunity

authors： Wei Z,Schnupf P,Poussin MA,Zenewicz LA,Shen H,Goldfine H

更新日期：2005-10-01 00:00:00

abstract：:Colony variants of Neisseria gonorrhoeae differ in their interactions with eucaryotic cells. When gonococci were cultivated with HeLa cell monolayers, the opacity phenotype (Op) became increasingly dominant in the subpopulation of organisms which adhered to the HeLa cells. Once bound, Op organisms displayed very low l...

journal_title：Infection and immunity

authors： Bessen D,Gotschlich EC

更新日期：1986-10-01 00:00:00

abstract：:The pH 6 antigen (Psa) of Yersinia pestis consists of fimbriae with adhesive properties of potential importance for the pathogenesis of plague, including pneumonic plague. The Psa fimbriae mediate bacterial binding to human alveolar epithelial cells. The Psa fimbriae bound mostly to one component present in the total ...

journal_title：Infection and immunity

authors： Galván EM,Chen H,Schifferli DM

更新日期：2007-03-01 00:00:00

abstract：:The bacterial pathogen Burkholderia pseudomallei invades host cells, escapes from endocytic vesicles, multiplies intracellularly, and induces the formation of actin tails and membrane protrusions, leading to direct cell-to-cell spreading. This study was aimed at the identification of B. pseudomallei genes responsible ...

journal_title：Infection and immunity

authors： Pilatz S,Breitbach K,Hein N,Fehlhaber B,Schulze J,Brenneke B,Eberl L,Steinmetz I

更新日期：2006-06-01 00:00:00

abstract：:Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. Of the 24 RAPD types de...

journal_title：Infection and immunity

authors： Darling P,Chan M,Cox AD,Sokol PA

更新日期：1998-02-01 00:00:00

abstract：:The present study was performed to examine whether Porphyromonas gingivalis fimbriae induce specifically a protein kinase-mediated phosphorylated protein that is involved in the mechanism of signal transduction. The fimbriae induced a 68-kDa phosphorylated protein (pp68) in a dose-dependent manner in mouse peritoneal ...

journal_title：Infection and immunity

authors： Murakami Y,Hanazawa S,Watanabe A,Naganuma K,Iwasaka H,Kawakami K,Kitano S

更新日期：1994-12-01 00:00:00