Replication of rubella virus in human mononuclear blood cells.

Abstract:

:Rubella virus was capable of replicating in both unstimulated and phytohemagglutinin-stimulated cultures of human mononuclear blood cells. Monocyte-derived macrophages were the main cell type responsible for viral replication. The susceptibility of macrophages increased during cultivation. Phytohemagglutinin-stimulated lymphocytes were able to support replication to a limited degree. No viral replication was detected in unstimulated lymphocytes. Both stimulation and viral replication in phytohemagglutinin-treated lymphocyte cultures were enhanced by the addition of murine macrophages. Human leukocyte interferon depressed the production of virus in these combined cultures. The finding that rubella virus is able to replicate in human lymphocytes as well as in macrophages may contribute to understanding the mechanisms of the suppressive effect of the virus on in vitro lymphocyte phytohemagglutinin responsiveness and in vivo immune functions.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

van der Logt JT,van Loon AM,van der Veen J

doi

10.1128/IAI.27.2.309-314.1980

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

309-14

issue

2

eissn

0019-9567

issn

1098-5522

journal_volume

27

pub_type

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