Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition.

abstract：:The influence of the leukotoxin of Pasteurella haemolytica on the generation of arachidonic acid metabolites by bovine polymorphonuclear leukocytes (PMNs) was investigated. PMNs released 5-, 12-, and 15-hydroxyeicosatetraenoic acids (5-, 12-, and 15-HETE) and leukotriene B4 (LTB4) upon stimulation with arachidonic aci...

journal_title：Infection and immunity

authors： Henricks PA,Binkhorst GJ,Drijver AA,Nijkamp FP

更新日期：1992-08-01 00:00:00

abstract：:Black melanin-like pigments are produced by several neurotropic fungi, including Cryptococcus neoformans. Pigment production is associated with virulence. In media containing phenolic substrates such as L-dopa, C. neoformans cells become black as a result of pigment accumulation. Pigmented and nonpigmented C. neoforma...

journal_title：Infection and immunity

authors： Wang Y,Aisen P,Casadevall A

更新日期：1995-08-01 00:00:00

abstract：:The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and long-term exposures of the cells to muramyl dipeptide (MDP) or lipopolysaccharide (LPS). Neither MDP nor LPS alone induce...

journal_title：Infection and immunity

authors： Yagawa K,Kaku M,Ichinose Y,Nagao S,Tanaka A,Tomoda A

更新日期：1984-07-01 00:00:00

abstract：:The lymphogranuloma venereum (LGV) and trachoma biovars of Chlamydia trachomatis exhibit differences in biological properties both in vivo and in vitro. To identify analogous biochemical differences, we studied the molecular charges of chlamydial outer membrane proteins (OMPs) by means of isoelectric focusing and none...

journal_title：Infection and immunity

authors： Batteiger BE,Newhall WJ 5th,Jones RB

更新日期：1985-11-01 00:00:00

abstract：:Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...

journal_title：Infection and immunity

authors： Thore M,Löfgren S,Tärnvik A,Monsen T,Selstam E,Burman LG

更新日期：1985-01-01 00:00:00

abstract：:Athymic BALB/c nude mice and euthymic BALB/c mice were infected with Rickettsia akari by the intraperitoneal route. The rickettsialpox infection was terminated in euthymic mice with only two intraperitoneal injections of the antibiotic oxytetracycline, whereas prolonged treatment was necessary to terminate the infecti...

journal_title：Infection and immunity

authors： Kenyon RH,Pedersen CE Jr

更新日期：1980-05-01 00:00:00

abstract：:Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce different disease manifestations in infected mice. Whereas serotype B causes more severe arthritis and reaches higher densities in the blood of mice than serotype A, serotype A invades the central nervous system earlier than serotype B duri...

journal_title：Infection and immunity

authors： Pennington PM,Cadavid D,Barbour AG

更新日期：1999-09-01 00:00:00

abstract：:Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the immunogenicity of three surface-exposed proteins from serogroup B Neisseria meningitidis (App, NhhA, and NadA) identified du...

journal_title：Infection and immunity

authors： Bowe F,Lavelle EC,McNeela EA,Hale C,Clare S,Arico B,Giuliani MM,Rae A,Huett A,Rappuoli R,Dougan G,Mills KH

更新日期：2004-07-01 00:00:00

abstract：:The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular ...

journal_title：Infection and immunity

authors： Shun CT,Lu SY,Yeh CY,Chiang CP,Chia JS,Chen JY

更新日期：2005-06-01 00:00:00

abstract：:We compared the immune defense of mice with chronic granulomatous disease (CGD mice) with that of wild-type C57BL/6 mice for their response to Sporothrix schenckii. A subcutaneous injection of 5 x 10(4) CFU S. schenckii strain IFM41598 into CGD mice resulted in systemic infection and death within 84 days. In contrast,...

journal_title：Infection and immunity

authors： Kajiwara H,Saito M,Ohga S,Uenotsuchi T,Yoshida S

更新日期：2004-09-01 00:00:00

abstract：:Pro- and anti-inflammatory cytokines and their signaling pathways play key roles in protection from and pathogenesis of mycobacterial infection, and their balance and dynamic changes may control or predict clinical outcome. Peripheral blood cells' capacity to produce proinflammatory (tumor necrosis factor alpha [TNF-a...

journal_title：Infection and immunity

authors： Sahiratmadja E,Alisjahbana B,de Boer T,Adnan I,Maya A,Danusantoso H,Nelwan RH,Marzuki S,van der Meer JW,van Crevel R,van de Vosse E,Ottenhoff TH

更新日期：2007-02-01 00:00:00

abstract：:Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins. Insertional inactivation of the plo gene results in loss of expression of PLO with a concomitant loss in hemolytic activity. The plo mutant, PLO-1, has an...

journal_title：Infection and immunity

authors： Jost BH,Songer JG,Billington SJ

更新日期：1999-04-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known abou...

journal_title：Infection and immunity

authors： Devyatyarova-Johnson M,Rees IH,Robertson BD,Turner MW,Klein NJ,Jack DL

更新日期：2000-07-01 00:00:00

abstract：:Outer membrane porin genes of Salmonella typhimurium, including ompC, ompF, and tppB, are regulated by the products of ompB, a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date no one has studied the intracellular trafficking of S. typhimurium porin-...

journal_title：Infection and immunity

authors： Mills SD,Ruschkowski SR,Stein MA,Finlay BB

更新日期：1998-04-01 00:00:00

abstract：:Variable subregions within the variant surface glycoprotein (VSG) coat displayed by African trypanosomes are predicted sites for T- and B-cell recognition. Hypervariable subregion 1 (HV-1) is localized to an internal amphipathic alpha helix in VSG monomers and may have evolved due to selective pressure by host T-cell ...

journal_title：Infection and immunity

authors： Dagenais TR,Demick KP,Bangs JD,Forest KT,Paulnock DM,Mansfield JM

更新日期：2009-01-01 00:00:00

abstract：:Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune ...

journal_title：Infection and immunity

authors： McDonald V,Deer R,Uni S,Iseki M,Bancroft GJ

更新日期：1992-08-01 00:00:00

abstract：:The role of gamma-delta T cells in host resistance to Chlamydia trachomatis was characterized by using a murine model of pneumonia caused by the mouse pneumonitis agent (MoPn), murine C. trachomatis. At days 3 and 7 after infection, gamma-delta T-cell-deficient knockout mice had significantly higher levels of MoPn in ...

journal_title：Infection and immunity

authors： Williams DM,Grubbs BG,Kelly K,Pack E,Rank RG

更新日期：1996-09-01 00:00:00

abstract：:Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this imm...

journal_title：Infection and immunity

authors： Perlmann P,Perlmann H,Flyg BW,Hagstedt M,Elghazali G,Worku S,Fernandez V,Rutta AS,Troye-Blomberg M

更新日期：1997-01-01 00:00:00

abstract：:Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

journal_title：Infection and immunity

authors： Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

更新日期：2003-09-01 00:00:00

abstract：:The antigenicity of Erysipelothrix rhusiopathiae T28 (serotype 2) was investigated. Antigens were solubilized from the cell surface with detergents. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting it was shown that the molecular weight of the main antigenic component--a nonprot...

journal_title：Infection and immunity

authors： Lachmann PG,Deicher H

更新日期：1986-06-01 00:00:00

abstract：:Dendritic cells (DC) suffer a maturation defect following interaction with erythrocytes infected with malaria parasites and become unable to induce protective malaria liver-stage immunity. Here we show that, by contrast, maturation-arrested DC in vitro are capable of the successful induction of antigen-specific gamma ...

journal_title：Infection and immunity

authors： Pouniotis DS,Proudfoot O,Bogdanoska V,Apostolopoulos V,Fifis T,Plebanski M

更新日期：2004-09-01 00:00:00

abstract：:Despite the autotransporter (AT) moniker, AT secretion appears to involve the function of periplasmic chaperones. We identified four periplasmic proteins that specifically bound to plasmid-encoded toxin (Pet), an AT produced by enteroaggregative Escherichia coli (EAEC). These proteins include the 17-kDa Skp chaperone ...

journal_title：Infection and immunity

authors： Tapia-Pastrana G,Chavez-Dueñas L,Lanz-Mendoza H,Teter K,Navarro-García F

更新日期：2012-07-01 00:00:00

abstract：:Bordetella bronchiseptica is closely related to Bordetella pertussis, which produces respiratory disease primarily in mammals other than humans. However, its importance as a human pathogen is being increasingly recognized. Although a large amount of research on Bordetella has been generated regarding protein virulence...

journal_title：Infection and immunity

authors： Sisti F,Fernández J,Rodríguez ME,Lagares A,Guiso N,Hozbor DF

更新日期：2002-04-01 00:00:00

abstract：:Treponema denticola is a cultivable oral spirochete which perturbs the cytoskeleton in cultured cells of oral origin, but intracellular signalling pathways by which it affects actin assembly are largely unknown. As the outer membrane (OM) of Treponema denticola disrupts actin-dependent processes that normally require ...

journal_title：Infection and immunity

authors： Ko KS,Glogauer M,McCulloch CA,Ellen RP

更新日期：1998-02-01 00:00:00

abstract：:Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) and TLR2-deficient (TLR2(-/-)) mice were inoculated with Streptococcus pneumoniae (...

journal_title：Infection and immunity

authors： Han F,Yu H,Tian C,Li S,Jacobs MR,Benedict-Alderfer C,Zheng QY

更新日期：2009-07-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) from three human and four monkey isolates of Campylobacter jejuni was extracted in high yields that revealed ladder-like structures in polyacrylamide gels by direct silver staining. These observations demonstrate that C. jejuni possesses LPS with O-chain repeating units typical of the family E...

journal_title：Infection and immunity

authors： Blake DC Jr,Russell RG

更新日期：1993-12-01 00:00:00

abstract：:Cell wall lytic enzyme (Kyowa lytic no. 2 enzyme) liberated arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. From these cell walls, mutanolysin (peptidoglycan-degrading enzyme) also liberated hydrosoluble peptidoglycans which, however, lacked arthritogenicit...

journal_title：Infection and immunity

authors： Kohashi O,Pearson CM,Watanabe Y,Kotani S

更新日期：1977-06-01 00:00:00

abstract：:Affinity-purified rabbit polyclonal (PAB96-1) and mouse monoclonal (1G9-1C2) antibodies to synthetic H-DDDDDDD-OH, an antimicrobial anionic peptide (AP) originally isolated from ovine pulmonary surfactant, were prepared and used to assess the concentrations of AP-like molecules in human respiratory tract samples. In b...

journal_title：Infection and immunity

authors： Brogden KA,Ackermann MR,McCray PB Jr,Huttner KM

更新日期：1999-08-01 00:00:00

abstract：:A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice w...

journal_title：Infection and immunity

authors： Burns DL,Gould-Kostka JL,Kessel M,Arciniega JL

更新日期：1991-04-01 00:00:00