Abstract:
:Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune to reinfection. In contrast, severe combined immunodeficiency (SCID) mice or nude mice had a chronic infection lasting at least 109 days. The development of the C. muris infection appeared to be confined to the gastric epithelium in immunocompetent and immunocompromised mice. SCID mice injected intraperitoneally with histocompatible spleen or mesenteric lymph node cells from uninfected BALB/c mice were able to recover from the C. muris infection. The protective effect of donor spleen cells was not reduced by depletion of the B cell population but was significantly reduced by depletion of Thy.1 cells. Treatment of C57BL/6 or BALB/c mice during infection with a gamma interferon-neutralizing monoclonal antibody, but not a tumor necrosis factor-neutralizing monoclonal antibody, resulted in a significant increase in oocyst production. In the C. parvum model, a severe and eventually fatal chronic infection with a cervine isolate was established in SCID mice, with parasitization occurring in the ileum, cecum, and colon. SCID mice injected with unprimed BALB/c spleen cells prior to inoculation of C. parvum oocysts were resistant to infection. These results suggested that the two animal models should be valuable in the study of immunity to cryptosporidial infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
McDonald V,Deer R,Uni S,Iseki M,Bancroft GJdoi
10.1128/IAI.60.8.3325-3331.1992keywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
3325-31issue
8eissn
0019-9567issn
1098-5522journal_volume
60pub_type
杂志文章abstract::The immunogenic and adjuvant properties of Brucella abortus and Escherichia coli lipopolysaccharides (LPSs) were studied in endotoxin-responsive, athymic, and euthymic BALB/c mice and in responsive C3H/HeAu mice and congenic nonresponsive C3H/HeJ mice. Consistent with previous reports, E. coli LPS did not stimulate si...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.1.74-80.1984
更新日期:1984-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2334-2339.1993
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journal_title:Infection and immunity
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doi:10.1128/IAI.60.8.3033-3041.1992
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abstract::Rabbit lymphoid cells from spleen, peripheral blood, and peritoneal cavity lacked killer (K)-cell activity against cell lines of rabbit and human origin, including virus-infected human tumor cells. This lack of activity was not affected by antibody concentration, source of antibodies, effector/target cell ratio, or le...
journal_title:Infection and immunity
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doi:10.1128/IAI.35.2.489-496.1982
更新日期:1982-02-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.53.3.700-701.1986
更新日期:1986-09-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.9.6.985-990.1974
更新日期:1974-06-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.01515-07
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.2991-2997.1989
更新日期:1989-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.4.1258-1266.1997
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.8.4716-4720.2002
更新日期:2002-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.3.1112-1118.1982
更新日期:1982-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.5559-5566.1999
更新日期:1999-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.422-430.2005
更新日期:2005-01-01 00:00:00
abstract::Infection of resistant or susceptible mice with Trichuris muris provokes mesenteric lymph node responses which are polarized towards Th2 or Th1, respectively. These responses are well documented in the literature. In contrast, little is known about the local responses occurring within the infected intestine. Through m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.7.4025-4033.2005
更新日期:2005-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1647-1655.1989
更新日期:1989-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.11.4147-4153.1991
更新日期:1991-11-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.40.2.529-533.1983
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.67.6.3055-3060.1999
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journal_title:Infection and immunity
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doi:10.1128/IAI.69.2.640-649.2001
更新日期:2001-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.636-644.1998
更新日期:1998-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.6.3.355-363.1972
更新日期:1972-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.2.478-483.1997
更新日期:1997-02-01 00:00:00
abstract::Capsular types 5 and 8, which account for about 70% of Staphylococcus aureus strains isolated from the blood of patients, resisted in vitro phagocytosis by human polymorphonuclear leukocytes (PMN). Antisera and monoclonal antibody to type 5 and 8 capsular polysaccharides (CPS) induced type-specific in vitro phagocytos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.5.1090-1095.1988
更新日期:1988-05-01 00:00:00
abstract::The Burkholderia cepacia epidemic strain marker (BCESM) is a useful epidemiological marker for virulent B. cenocepacia strains that infect patients with cystic fibrosis. However, there was no evidence that the original marker, identified by random amplified polymorphic DNA fingerprinting, contributed to pathogenicity....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.3.1537-1547.2004
更新日期:2004-03-01 00:00:00
abstract::Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.4.2408-2411.2004
更新日期:2004-04-01 00:00:00
abstract::Hamster (Mesocricetus auratus) neutrophil granules contain at least four microbicidal peptides belonging to the defensin family. These compounds were purified from granule acid extracts by reverse-phase chromatography and termed HaNP-1 to -4 (hamster neutrophil peptide). HaNP-1 and HaNP-3 revealed the most bactericida...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.11.4444-4449.1996
更新日期:1996-11-01 00:00:00
abstract::We have previously demonstrated that protection from allergic inflammation by Ascaris suum infection was characterized by a global increase in interleukin-10 (IL-10) and the development of protective CD4(+)/CD25(+) T cells (L. Schopf, S. Luccioli, V. Bundoc, P. Justice, C. C. Chan, B. J. Wetzel, H. H. Norris, J. F. Ur...
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pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00