Abstract:
:Herpes simplex virus (HSV) infection of mouse liver after partial hepatectomy was studied. Partial hepatectomy resulted in the rapid onset of cellular DNA synthesis and the appearance of many mitotic figures (peak, 3 days after surgery). Similar changes were not seen in control animals. After partial hepatectomy, the mice were infected with thymidine kinase-positive (TK+) and -negative (TK-) HSV to investigate virus titers in liver tissue during liver cell replication. In control unoperated mice, liver titers of TK+ HSV (2 X 10(3) PFU/g) were greater than those of mice inoculated with TK HSV (4 X 10(1) to 5 X 10(2) PFU/g). After partial hepatectomy, TK+ and TK- HSV titers increased, and peak TK+ and TK- HSV titers were similar (6 X 10(5) to 8 X 10(5) PFU/g). Hepatic infection was further investigated by infectious center (IC) assays. The numbers of ICs for TK+ HSV increased 50-fold after partial hepatectomy, whereas the increase was less for TK- HSV. From the results of these studies, we hypothesize that the increase in hepatic TK+ HSV after hepatectomy may have been largely due to the increase in ICs, whereas the increase in hepatic TK- HSV was due, in part, to the increase in ICs, but may also have been due to the enhanced synthesis of TK- HSV in replicating liver cells.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Fang ZY,Tenser RB,Rapp Fdoi
10.1128/IAI.42.1.402-408.1983subject
Has Abstractpub_date
1983-10-01 00:00:00pages
402-8issue
1eissn
0019-9567issn
1098-5522journal_volume
42pub_type
杂志文章abstract::The fibronectin-degrading ability of 116, mainly oral, strains was assayed by using plasma-derived fibronectin adsorbed to a polystyrene surface. Ability to degrade fibronectin was revealed in strains of Bacteroides gingivalis, Bacteroides intermedius, Bacteroides loeschii, Staphylococcus aureus, Staphylococcus epider...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.2.707-711.1986
更新日期:1986-02-01 00:00:00
abstract::Platelet microbicidal proteins (PMPs) are small, cationic peptides which possess potent microbicidal activities against common bloodstream pathogens, such as Staphylococcus aureus. We previously showed that S. aureus strains exhibiting resistance to thrombin-induced PMP (tPMP-1) in vitro have an enhanced capacity to c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.6.3548-3553.2000
更新日期:2000-06-01 00:00:00
abstract::After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.27-33.1979
更新日期:1979-07-01 00:00:00
abstract::Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.4.1150-1155.1994
更新日期:1994-04-01 00:00:00
abstract::In this report, we demonstrate that the variable antigens present on the surface of Plasmodium knowlesi-infected erythrocytes could not be found on the surface of merozoites. A number of technical problems had to be solved to make such a comparative study possible, including the purification of merozoites by affinity ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.1.275-284.1981
更新日期:1981-07-01 00:00:00
abstract::Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. The elution was performed with 1 M MgCl2. The component could be isolated from sonicated preparations of whole cells, cell walls, and extrace...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.700-708.1985
更新日期:1985-09-01 00:00:00
abstract::Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.8.4736-4745.2000
更新日期:2000-08-01 00:00:00
abstract::Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, and Na-GST-3, respectively) were isolated ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00848-09
更新日期:2010-04-01 00:00:00
abstract::Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.9.5436-5439.2003
更新日期:2003-09-01 00:00:00
abstract::Antisera were produced by inoculation of mycoplasma cells grown in PPLO broth supplemented with rabbit serum alone or rabbit serum plus Freund complete or incomplete adjuvant. By using an enzyme-linked immunosorbent assay, immunoglobulin G antibodies to cholesterol were detected in antisera to mycoplasmas (Mycoplasma ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.6.2200-2202.1991
更新日期:1991-06-01 00:00:00
abstract::The gene encoding the 56-kDa protein of Orientia tsutsugamushi Shanxi was amplified by a nested PCR and cloned into the expression vector pQE30. The 56-kDa protein of O. tsutsugamushi Shanxi (Sxh56) was expressed as a fusion protein with the His(6)-binding protein of Escherichia coli by deleting the signal peptide-enc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.8.4772-4779.2003
更新日期:2003-08-01 00:00:00
abstract::Effector mechanisms resulting from alternative complement pathway (ACP) activation cannot act efficiently against Yersinia enterocolitica serotype O3, as indicated by poor C3 to C9 consumption and by survival in EGTA (ethyleneglycoldiaminetetraacetic acid) Mg-serum. These results were not influenced by the lack or pre...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.7.1984-1989.1989
更新日期:1989-07-01 00:00:00
abstract::The genes encoding alpha-hemolysin and mannose-resistant hemagglutination were shown to be closely linked in cloned DNA from two Escherichia coli urinary tract isolates of serotypes O4 (J96) and O6 (C1212). DNA hybridization experiments demonstrated that the hly and mrh gene clusters of other E. coli O6 serotypes were...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.1.353-358.1984
更新日期:1984-01-01 00:00:00
abstract::The question of whether Campylobacter jejuni produces a cholera toxin-like toxin (CTLT) has been controversial. The objective of this study was to identify the factor that cross-reacts with CT from C. jejuni. Filtrates of C. jejuni grown in four different liquid media reported to promote CTLT production were tested by...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00139-07
更新日期:2007-06-01 00:00:00
abstract::The gastric spirillum Helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. Studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with H. felis. At 2 weeks postinoculation, the gastric mucosa of germfree rats had ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.3.785-791.1991
更新日期:1991-03-01 00:00:00
abstract::Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric contents of the stomach leak into the esophagus, in many cases resulting in aspiration into the respiratory tract. As such,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00674-13
更新日期:2014-09-01 00:00:00
abstract::Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1289-1296.2000
更新日期:2000-03-01 00:00:00
abstract::Major research efforts are directed towards the development of a better antimycobacterial vaccine. But progress in the field of tuberculosis vaccine development has been hampered by the lack of human in vitro models to assess vaccine immunogenicity and efficacy. New candidate vaccines will have to be evaluated against...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.11.6401-6407.2004
更新日期:2004-11-01 00:00:00
abstract::The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRR) and transduces downstream signaling to activate the host defense. Here we report that in addition to direct PAMP-PRR interactions, live Candida albicans cells can release soluble factors to ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01041-09
更新日期:2010-01-01 00:00:00
abstract::Analysis of major outer membrane protein (MOMP) profiles of various meningococci by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (SDS-PAGE) revealed the presence of 0 to 2 low-molecular-weight, heat-modifiable MOMPs (molecular weight, 25,000 to 32,000) and 1 to 3 high-molecular-weight MOMPs (molecul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Clostridium perfringens type B causes enteritis and enterotoxemia in domestic animals. By definition, these bacteria must produce alpha toxin (CPA), beta toxin (CPB) and epsilon toxin (ETX) although most type B strains also produce perfringolysin O (PFO) and beta2 toxin (CPB2). A recently identified Agr-like quorum-se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00438-12
更新日期:2012-09-01 00:00:00
abstract::While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.5204-5207.2005
更新日期:2005-08-01 00:00:00
abstract::Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of be...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.895-899.1982
更新日期:1982-03-01 00:00:00
abstract::In order to further understand Epstein-Barr virus (EBV)-lymphocyte interactions, we investigated a chain of events including: (i) EBV binding to human lymphocyte subpopulations; (ii) the earliest appearance of EBV-determined nuclear antigen (EBNA) in the lymphocytes after EBV infection; and (iii) establishment of cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.2.303-310.1976
更新日期:1976-02-01 00:00:00
abstract::Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.3.936-942.1997
更新日期:1997-03-01 00:00:00
abstract::The objective of this research was to determine whether gram-negative bacteria frequently isolated from periodontally diseased sites contained polyclonal B-cell activators. Polyclonal B-cell activation, which results in nonspecific activation of multiple B-cell clones was analyzed by a hemolysis-in-gel assay designed ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.1.43-49.1981
更新日期:1981-10-01 00:00:00
abstract::We previously reported that two surface-exposed high-molecular-weight proteins, HMW1 and HMW2, expressed by a prototypic strain of nontypeable Haemophilus influenzae (NTHI) mediate attachment to human epithelial cells. These proteins are members of a family of highly immunogenic proteins common to most nontypeable Hae...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.8.3032-3037.1996
更新日期:1996-08-01 00:00:00
abstract::Pseudomonas aeruginosa elastase rapidly inactivates alpha 1-proteinase inhibitor by splitting its Pro-357-Met-358 peptide bond. The present study was aimed at testing whether this reaction takes place in the presence of leukocyte elastase. To this end was added alpha 1-proteinase inhibitor to a mixture of the two elas...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.12.3793-3797.1989
更新日期:1989-12-01 00:00:00
abstract::At pH 7.4 and in the presence of NaHCO3, human milk and bovine colostrum inhibited the growth of Escherichia coli O111. Adding sufficient iron to saturate the iron-binding capacity of the lactoferrin present in the milk or colostrum prevented bacteriostasis. At pH 6.8 neither molk nor colostrum inhibited E. coli 0111....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.396-401.1977
更新日期:1977-02-01 00:00:00
abstract::Anaplasma phagocytophilum is an obligate intracellular bacterium that infects myeloid cells in the mammalian host. Msp2 (p44) is the major immunodominant outer-membrane protein of these bacteria. We hypothesized that Msp2 acts as an adhesin for A. phagocytophilum entry into granulocytes. This potential role was invest...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.7.4018-4025.2003
更新日期:2003-07-01 00:00:00