Variability of low-molecular-weight, heat-modifiable outer membrane proteins of Neisseria meningitidis.

abstract：:By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...

journal_title：Infection and immunity

authors： Osada Y,Mitsuyama M,Une T,Matsumoto K,Otani T,Satoh M,Ogawa H,Nomoto K

更新日期：1982-07-01 00:00:00

abstract：:A lectin with strong hemagglutinating activity toward erythrocytes of several animal species was isolated from an 18-h culture supernatant of a diarrheagenic strain, V2, of non-O1 Vibrio cholerae. The hemagglutinin (HA) was purified free of lipopolysaccharide by salt fractionation followed by gel filtration, hydrophob...

journal_title：Infection and immunity

authors： Banerjee KK,Ghosh AN,Dutta-Roy K,Pal SC,Ghose AC

更新日期：1990-11-01 00:00:00

abstract：:The extracellular cysteine protease from Streptococcus pyogenes is a virulence factor that plays a significant role in host-pathogen interaction. Streptococcal protease is expressed as an inactive 40-kDa precursor that is autocatalytically converted into a 28-kDa mature (active) enzyme. Replacement of the single cyste...

journal_title：Infection and immunity

authors： Matsuka YV,Pillai S,Gubba S,Musser JM,Olmsted SB

更新日期：1999-09-01 00:00:00

abstract：:Bordetella bronchiseptica is closely related to Bordetella pertussis, which produces respiratory disease primarily in mammals other than humans. However, its importance as a human pathogen is being increasingly recognized. Although a large amount of research on Bordetella has been generated regarding protein virulence...

journal_title：Infection and immunity

authors： Sisti F,Fernández J,Rodríguez ME,Lagares A,Guiso N,Hozbor DF

更新日期：2002-04-01 00:00:00

abstract：:Purified beta-toxin from Clostridium perfringens type C was found to be a single polypeptide chain protein with a molecular weight of approximately 30,000. The toxin was heat labile, with 75% of its activity being inactivated by incubation at 50 degrees C for 5 min. Biological activity of the purified toxin was comple...

journal_title：Infection and immunity

authors： Sakurai J,Duncan CL

更新日期：1978-08-01 00:00:00

abstract：:Investigating the innate immune response mediators released in milk has manifold implications, spanning from elucidation of the role played by mammary epithelial cells (MECs) in fighting microbial infections to the discovery of novel diagnostic markers for monitoring udder health in dairy animals. Here, we investigate...

journal_title：Infection and immunity

authors： Addis MF,Pisanu S,Marogna G,Cubeddu T,Pagnozzi D,Cacciotto C,Campesi F,Schianchi G,Rocca S,Uzzau S

更新日期：2013-09-01 00:00:00

abstract：:The inactivation of Coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (UV) light was studied. The effect of UV treatment on the activity of macrophage organelle marker enzymes and their subsequent equilibration in linear sucrose gradients was also determined. It was sho...

journal_title：Infection and immunity

authors： Little JS,Kishimoto RA,Canonico PG

更新日期：1980-03-01 00:00:00

abstract：:The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and long-term exposures of the cells to muramyl dipeptide (MDP) or lipopolysaccharide (LPS). Neither MDP nor LPS alone induce...

journal_title：Infection and immunity

authors： Yagawa K,Kaku M,Ichinose Y,Nagao S,Tanaka A,Tomoda A

更新日期：1984-07-01 00:00:00

abstract：:Periodontitis is a bacterium-induced chronic inflammation that destroys tissues that attach teeth to jaw bone. Pathologically excessive matrix metalloproteinase 8 (MMP-8) is among the key players in periodontal destruction by initiating type I collagen degradation. We studied MMP-8 in Porphyromonas gingivalis-induced ...

journal_title：Infection and immunity

authors： Kuula H,Salo T,Pirilä E,Tuomainen AM,Jauhiainen M,Uitto VJ,Tjäderhane L,Pussinen PJ,Sorsa T

更新日期：2009-02-01 00:00:00

abstract：:Immunoprecipitation of radiolabeled antigens with bovine antisera indicated that many Babesia bigemina and Babesia bovis merozoite proteins contain isolate-common epitopes, while at least 16 B. bigemina and 8 B. bovis proteins contain species-cross-reactive epitopes. One immunogenic, isolate-common, and species-specif...

journal_title：Infection and immunity

authors： McElwain TF,Palmer GH,Goff WL,McGuire TC

更新日期：1988-06-01 00:00:00

abstract：:Human polymorphonuclear leukocytes from normal subjects produced proinflammatory cytokines in response to stimulation with Cryptococcus neoformans yeast cells. The cytokines released after stimulation of neutrophils included interleukin-1beta (IL-1beta), IL-6, IL-8 and tumor necrosis factor alpha. The magnitude of the...

journal_title：Infection and immunity

authors： Retini C,Vecchiarelli A,Monari C,Tascini C,Bistoni F,Kozel TR

更新日期：1996-08-01 00:00:00

abstract：:Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...

journal_title：Infection and immunity

authors： Sekiya K,Kawahira M,Nakase Y

更新日期：1983-08-01 00:00:00

abstract：:Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...

journal_title：Infection and immunity

authors： Middleton PJ,Petric M,Szymanski MT

更新日期：1975-12-01 00:00:00

abstract：:Female mice infected at birth with 10(7) 50% tissue culture infective doses of polyoma virus were mated when at least 6 weeks old. Polyoma was not detected in any tissues of 27 female mice before mating except for trace amounts in the kidneys of 2 mice, but late in gestation polyoma virus could be found in the kidneys...

journal_title：Infection and immunity

authors： McCance DJ,Mims CA

更新日期：1979-09-01 00:00:00

abstract：:The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic class for treating serious fungal infections is the potential for drug resistance development. In this study we have is...

journal_title：Infection and immunity

authors： Kurtz MB,Abruzzo G,Flattery A,Bartizal K,Marrinan JA,Li W,Milligan J,Nollstadt K,Douglas CM

更新日期：1996-08-01 00:00:00

abstract：:The nucleotide sequences of three previously undescribed Pseudomonas aeruginosa pilin structural genes are presented. Comparisons of deduced pilin primary structure and flanking DNA sequence allowed placement of these and six previously published sequences into one of two groups. Epitope mapping, using overlapping imm...

journal_title：Infection and immunity

authors： Castric PA,Deal CD

更新日期：1994-02-01 00:00:00

abstract：:Repeated immunizations of CF1 mice with irradiated noninfectious Trypanosoma cruzi trypomastigotes resulted in partial protection against infection with live parasites. It also induced a limited number of antibody species that were reactive in Western blots with trypomastigote but not with epimastigote or amastigote p...

journal_title：Infection and immunity

authors： Zweerink HJ,Weston HD,Andersen OF,Garber SS,Hayes EC

更新日期：1984-12-01 00:00:00

abstract：:Knowledge of whether Mycobacterium tuberculosis resides within a relatively impermeable membrane-bound vacuole or is free within the cytoplasm within its host cell is central to an understanding of the immunobiology of this intracellular parasite but is a matter of controversy. To explore this issue, we assessed the a...

journal_title：Infection and immunity

authors： Clemens DL,Lee BY,Horwitz MA

更新日期：2002-10-01 00:00:00

abstract：:Interleukin-10 (IL-10) is associated with inhibition of cell-mediated immunity and downregulation of the expression of costimulatory molecules required for T-cell activation. When IL-10-deficient (IL-10KO) mice are infected with Toxoplasma gondii, they succumb to a T-cell-mediated shock-like reaction characterized by ...

journal_title：Infection and immunity

authors： Villegas EN,Wille U,Craig L,Linsley PS,Rennick DM,Peach R,Hunter CA

更新日期：2000-05-01 00:00:00

abstract：:A 60-kilodalton (kDa) immunodominant antigen of Legionella pneumophila is a heat shock protein (HSP) of the GroEL class of HSPs. The gene (htpB) coding the 60-kDa protein was localized to a 3.2-kilobase DNA fragment of L. pneumophila cloned into pUC19 (pSH16) (P. S. Hoffman, C. A. Butler, and F. D. Quinn, Infect. Immu...

journal_title：Infection and immunity

authors： Hoffman PS,Houston L,Butler CA

更新日期：1990-10-01 00:00:00

abstract：:In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar T...

journal_title：Infection and immunity

authors： Bourgeois JS,Zhou D,Thurston TLM,Gilchrist JJ,Ko DC

更新日期：2018-08-22 00:00:00

abstract：:The coexistence of bacteria in natural environments can often be explained in terms of competition for a growth-limiting substrate(s), and the outcome of such competition depends upon relevant growth parameters such as substrate affinity and yield. Dental plaque bacteria are frequently carbon and energy limited. Growt...

journal_title：Infection and immunity

authors： Rogers AH,de Jong MH,Zilm PS,van der Hoeven JS

更新日期：1986-06-01 00:00:00

abstract：:Borrelia burgdorferi elicits a potent cytokine response through activation of multiple signaling receptors on innate immune cells. Spirochetal lipoproteins initiate expression of NF-κB-dependent cytokines primarily via TLR2, whereas type I interferon (IFN) production is induced through the endosomal receptors TLR7 and...

journal_title：Infection and immunity

authors： Love AC,Schwartz I,Petzke MM

更新日期：2014-06-01 00:00:00

abstract：:Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. The elution was performed with 1 M MgCl2. The component could be isolated from sonicated preparations of whole cells, cell walls, and extrace...

journal_title：Infection and immunity

authors： Espersen F,Clemmensen I,Barkholt V

更新日期：1985-09-01 00:00:00

abstract：:Mice receiving a single injection of cyclophosphamide (150 mg/kg) 1 to 6 days before inoculation with viable Candida albicans showed an increased susceptibility to the challenge accompanied by a reduction in peripheral blood polymorphonuclear leukocytes and lymphocytes as well as in spleen cellularity. Several immunol...

journal_title：Infection and immunity

authors： Bistoni F,Baccarini M,Blasi E,Marconi P,Puccetti P,Garaci E

更新日期：1983-04-01 00:00:00

abstract：:This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...

journal_title：Infection and immunity

authors： Lindbäck T,Hardy SP,Dietrich R,Sødring M,Didier A,Moravek M,Fagerlund A,Bock S,Nielsen C,Casteel M,Granum PE,Märtlbauer E

更新日期：2010-09-01 00:00:00

abstract：:Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produ...

journal_title：Infection and immunity

authors： Selgrade MK,Nedrud JG,Collier AM,Gardner DE

更新日期：1981-09-01 00:00:00

abstract：:Host control of Coxiella burnetii infections is believed to be mediated primarily by activated monocytes/macrophages. The activation of macrophages by cytokines leads to the production of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) that have potent antimicrobial activities. The contri...

journal_title：Infection and immunity

authors： Brennan RE,Russell K,Zhang G,Samuel JE

更新日期：2004-11-01 00:00:00

abstract：:Fifty Borellia burgdorferi strains isolated from humans and ticks in Europe and the United States were analyzed by multilocus enzyme electrophoresis. Eleven genetic loci were characterized on the basis of the electrophoretic mobilities of their products. Ten loci were polymorphic. The average number of alleles per loc...

journal_title：Infection and immunity

authors： Boerlin P,Peter O,Bretz AG,Postic D,Baranton G,Piffaretti JC

更新日期：1992-04-01 00:00:00

abstract：:Pathogenicity of Rickettsia tsutsugamushi for laboratory mice is known to be influenced by at least three factors: (i) route of inoculation, (ii) antigenic strain, and (iii) natural resistance of the host. By using Karp, Gilliam, and Kato strains of R. tsutsugamushi, we examined the effect of these three pathogenicity...

journal_title：Infection and immunity

authors： Groves MG,Kelly DJ

更新日期：1989-05-01 00:00:00