The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm.

abstract：:Borrelias that cause Lyme disease lose the ability to infect and cause disease in laboratory animals following 10 to 16 passages of in vitro culture. In this study, clonal populations of the Sh-2-82 (Sh2) and B31 strains of Borrelia burgdorferi were isolated by subsurface plating on BSK-II agar plates and examined for...

journal_title：Infection and immunity

authors： Norris SJ,Howell JK,Garza SA,Ferdows MS,Barbour AG

更新日期：1995-06-01 00:00:00

abstract：:A group of insertion mutants was used to define the genes of plasmid pDC5 required for the expression of mannose-resistant fimbriae. Minicell experiments identified four polypeptides (71,000, 45,000, 27,000, and 17,000 daltons) concerned with fimbrial production, the smallest of these being the fimbrial subunit. The a...

journal_title：Infection and immunity

authors： Clegg S,Pierce JK

更新日期：1983-12-01 00:00:00

abstract：:Adherence of blastoconidia to epidermal corneocytes is an early event in Candida colonization and infection of the skin. Pathogenic species adhere more avidly than nonpathogenic species, transform to hyphal growth, and invade the stratum corneum of the skin. Adherence was studied by scanning electron microscopy of exp...

journal_title：Infection and immunity

authors： Ray TL,Payne CD

更新日期：1988-08-01 00:00:00

abstract：:Many vaccines containing somatic and secreted antigens of Pseudomonas aeruginosa have been reported. The vaccines containing lipopolysaccharide have been found to provide type-specific protection, but the endotoxin content of these vaccines does not make it feasible to use them in patients who are already debilitated....

journal_title：Infection and immunity

authors： Fernandes PB,Kim C,Cundy KR,Haung NN

更新日期：1981-08-01 00:00:00

abstract：:Galectin-3 (Gal-3) is a multifunctional beta-galactoside-binding lectin that senses self-derived and microbial glycoconjugates. Although Gal-3 is important in immune reactions and host defense in some experimental models, the function of Gal-3 during helminthic diseases (e.g., schistosomiasis) is still elusive. We sho...

journal_title：Infection and immunity

authors： Breuilh L,Vanhoutte F,Fontaine J,van Stijn CM,Tillie-Leblond I,Capron M,Faveeuw C,Jouault T,van Die I,Gosset P,Trottein F

更新日期：2007-11-01 00:00:00

abstract：:Shiga toxin type 1 (Stx1) belongs to the Shiga family of bipartite AB toxins that inactivate eukaryotic 60S ribosomes. The A subunit of Stxs are N-glycosidases that share structural and functional features in their catalytic center and in an internal hydrophobic region that shows strong transmembrane propensity. Both ...

journal_title：Infection and immunity

authors： Suhan ML,Hovde CJ

更新日期：1998-11-01 00:00:00

abstract：:The antigenicity of Erysipelothrix rhusiopathiae T28 (serotype 2) was investigated. Antigens were solubilized from the cell surface with detergents. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting it was shown that the molecular weight of the main antigenic component--a nonprot...

journal_title：Infection and immunity

authors： Lachmann PG,Deicher H

更新日期：1986-06-01 00:00:00

abstract：:The adherence of Candida species yeast cells to bovine and human endothelium was measured. The adherence phenomenon is a saturable event which can be altered by the release of prostaglandin I2 (PGI2 or prostacyclin) by endothelial cells. Release of PGI2 by endothelium has a protective effect, reducing Candida albicans...

journal_title：Infection and immunity

authors： Klotz SA

更新日期：1994-04-01 00:00:00

abstract：:Attenuated Yersinia pestis pgm strains, such as KIM5, lack the siderophore yersiniabactin. Strain KIM5 does not induce significant pneumonia when delivered intranasally. In this study, mice were found to develop pneumonia after intranasal challenge with strain KIM5 when they were injected intraperitoneally with iron d...

journal_title：Infection and immunity

authors： Galván EM,Nair MK,Chen H,Del Piero F,Schifferli DM

更新日期：2010-08-01 00:00:00

abstract：:Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4(+) T cells and contain very low numbers of cel...

journal_title：Infection and immunity

authors： San Mateo LR,Toffer KL,Orndorff PE,Kawula TH

更新日期：1999-09-01 00:00:00

abstract：:Improvement of antibody responses to polysaccharides through their linkage to proteins is thought to be mediated by protein-specific T helper (Th) cells. To investigate whether the carrier protein of a conjugate could be substituted by a Th epitope, Streptococcus pneumoniae type 17F polysaccharide (PS) was bromoacetyl...

journal_title：Infection and immunity

authors： de Velasco EA,Merkus D,Anderton S,Verheul AF,Lizzio EF,Van der Zee R,Van Eden W,Hoffman T,Verhoef J,Snippe H

更新日期：1995-03-01 00:00:00

abstract：:Exohemagglutinin was found in the culture medium of Bacteroides gingivalis 381. Exohemagglutinin was purified 3,150-fold from culture fluid by ultracentrifugation followed by gel filtration on Sepharose CL-4B and by affinity chromatography on arginine-agarose. Examination of the final preparation of exohemagglutinin b...

journal_title：Infection and immunity

authors： Inoshita E,Amano A,Hanioka T,Tamagawa H,Shizukuishi S,Tsunemitsu A

更新日期：1986-05-01 00:00:00

abstract：:Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity and the req...

journal_title：Infection and immunity

authors： Carapau D,Mitchell R,Nacer A,Shaw A,Othoro C,Frevert U,Nardin E

更新日期：2013-12-01 00:00:00

abstract：:Mycoplasma pneumoniae is a leading, worldwide cause of death and disability due to pneumonia. Mycoplasma pulmonis infection in mice is an invaluable model for the study of host defenses against respiratory mycoplasmas in vivo. C3H/HeN mice are much more susceptible to acute inflammatory lung disease due to M. pulmonis...

journal_title：Infection and immunity

authors： Cartner SC,Simecka JW,Lindsey JR,Cassell GH,Davis JK

更新日期：1995-10-01 00:00:00

abstract：:Strains of type III group B streptococci isolated from patients with neonatal sepsis are generally resistant to complement-mediated phagocytic killing in the absence of specific antibody. It has been suggested that the resistance of type III group B streptococci to phagocytosis results from inhibition of alternative-c...

journal_title：Infection and immunity

authors： Marques MB,Kasper DL,Pangburn MK,Wessels MR

更新日期：1992-10-01 00:00:00

abstract：:A monoclonal antibody was used to characterize a 135-kDa surface-located membrane protein (Lmp1) generally present in Mycoplasma hominis strains. The monoclonal antibody, 552, was applied to identify the corresponding gene in an expression library of M. hominis PG21 DNA. The M. hominis PG21 lmp1 gene was sequenced, an...

journal_title：Infection and immunity

authors： Ladefoged SA,Birkelund S,Hauge S,Brock B,Jensen LT,Christiansen G

更新日期：1995-01-01 00:00:00

abstract：:Oligopeptides play important roles in bacterial nutrition and signaling. Using sequences from the available genome database for Mycobacterium tuberculosis H37Rv, the oligopeptide permease operon (oppBCDA) of Mycobacterium bovis BCG was cloned from a cosmid library. An opp mutant strain was constructed by homologous re...

journal_title：Infection and immunity

authors： Green RM,Seth A,Connell ND

更新日期：2000-02-01 00:00:00

abstract：:Nasopharyngeal colonization represents the initial interaction between Haemophilus influenzae and its human host. Factors that influence bacterial carriage likely affect transmission and incidence of infection. Therefore, we investigated host factors involved in limiting H. influenzae colonization in BALB/c mice, as c...

journal_title：Infection and immunity

authors： Zola TA,Lysenko ES,Weiser JN

更新日期：2009-08-01 00:00:00

abstract：:A crude complex containing group C polysaccharide, outer membrane proteins, and lipopolysaccharide (LPS) was isolated from the cell-free culture liquid of Neisseria meningitidis serogroup C, serotype 2a. Group C polysaccharide and LPS were removed from this complex, resulting in an outer membrane complex and a purifie...

journal_title：Infection and immunity

authors： Beuvery EC,Miedema F,van Delft RW,Haverkamp J,Leussink AB,te Pas BJ,Teppema KS,Tiesjema RH

更新日期：1983-04-01 00:00:00

abstract：:Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we demonstrated that TLR2...

journal_title：Infection and immunity

authors： Gharaibeh M,Hagedorn M,Lilla S,Hauptmann M,Heine H,Fleischer B,Keller C

更新日期：2016-11-18 00:00:00

abstract：:The possibility that soluble products of Schistosoma mansoni eggs might participate in the pathogenesis of hepatic fibrosis in schistosomiasis was investigated. Both crude saline extracts of eggs (soluble egg antigen [SEA]) and a partially purified SEA fraction contained activity which stimulated guinea pig and human ...

journal_title：Infection and immunity

authors： Wyler DJ,Tracy JW

更新日期：1982-10-01 00:00:00

abstract：:Escherichia coli C25 maintained population levels of 10(9) to 10(10) per g of cecum and translocated to 100% of the middle mesenteric lymph nodes in gnotobiotic mice monoassociated with E. coli C25. Intragastric inoculation of these mice with the cecal contents from specific-pathogen-free mice reduced the population l...

journal_title：Infection and immunity

authors： Berg RD

更新日期：1980-09-01 00:00:00

abstract：:Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since...

journal_title：Infection and immunity

authors： Simonson LG,Rouse RF,Bockowski SW

更新日期：1988-01-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are produced by neutrophils as an innate immune defense mechanism to trap and kill microbial pathogens. NETs are comprised of ejected chromatin that forms a lattice structure enmeshed with numerous antimicrobial proteins. In addition to forming the structural backbone of NETs, ext...

journal_title：Infection and immunity

authors： Wilton M,Halverson TWR,Charron-Mazenod L,Parkins MD,Lewenza S

更新日期：2018-08-22 00:00:00

abstract：:The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin antigen, choleragen, choleragenoid, and Formalin-treated choleragen (formagen). The results indicated that choleragen evoke...

journal_title：Infection and immunity

authors： Finkelstein RA,Hollingsworth RC

更新日期：1970-05-01 00:00:00

abstract：:The microbicidal myeloperoxidase (MPO)-H2O2-chloride system strongly inhibits Escherichia coli DNA synthesis. Also, cell envelopes from MPO-treated E. coli cells lose their ability to interact with hemimethylated DNA sequences of oriC, the chromosomal origin of replication, raising the prospect that suppression of DNA...

journal_title：Infection and immunity

authors： Rosen H,Michel BR,vanDevanter DR,Hughes JP

更新日期：1998-06-01 00:00:00

abstract：:The effects of an ornithine-containing lipid [alpha-N-(3-acyloxyacyl)-ornithine (Orn-L)] or a serine-containing lipid [alpha-N-(3-acyloxyacyl)-serine (Ser-L)] from Flavobacterium meningosepticum on lethal endotoxemia in mice were examined. When 500 micrograms of Orn-L was intravenously administered 1 h before intraven...

journal_title：Infection and immunity

authors： Kawai Y,Kaneda K,Morisawa Y,Akagawa K

更新日期：1991-08-01 00:00:00

abstract：:Although protective immunity in C57BL/6 mice induced by a single dose of the radiation-attenuated schistosome vaccine is believed to be mediated by Th1-type immune responses, we here report that in BALB/c mice protection can also depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs ...

journal_title：Infection and immunity

authors： Mountford AP,Hogg KG,Coulson PS,Brombacher F

更新日期：2001-01-01 00:00:00

abstract：:Larvae of the helminth parasite Schistosoma mansoni are efficiently killed in vitro by lymphokine-activated macrophages, leading to the hypothesis that these cells may participate in the effector mechanism of protective immunity against schistosomiasis. Larvacidal activity has also been demonstrated in the IC-21 macro...

journal_title：Infection and immunity

authors： James SL,Glaven JA

更新日期：1987-12-01 00:00:00

abstract：:Numerous bacterial pathogens use type III secretion systems (T3SSs) or T4SSs to inject or translocate virulence proteins into eukaryotic cells. Several different reporter systems have been developed to measure the translocation of these proteins. In this study, a peptide tag-based reporter system was developed and use...

journal_title：Infection and immunity

authors： Garcia JT,Ferracci F,Jackson MW,Joseph SS,Pattis I,Plano LR,Fischer W,Plano GV

更新日期：2006-10-01 00:00:00