Immune cells are required for cutaneous ulceration in a swine model of chancroid.

abstract：:Conventionally raised suckling mice were injected intragastrically with 10(5) spores of a Clostridium botulinum type A culture. Botulism was not observed, but 80% or more of mice challenged when 8 to 11 days old had botulinum toxin in the large intestine 3 days later. Mice younger than 7 days or older than 15 days wer...

journal_title：Infection and immunity

authors： Sugiyama H,Mills DC

更新日期：1978-07-01 00:00:00

abstract：:There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. conorii, which causes boutonneuse fever. The gene encoding the R. rickettsii...

journal_title：Infection and immunity

authors： Vishwanath S,McDonald GA,Watkins NG

更新日期：1990-03-01 00:00:00

abstract：:To study the specific role of transmembrane tumor necrosis factor (tmTNF) in protective and pathological responses against the gastrointestinal helminth Trichinella spiralis, we compared the immune responses of TNF-alpha/lymphotoxin alpha (LTalpha)(-/-) mice expressing noncleavable transgenic tmTNF to those of TNF-alp...

journal_title：Infection and immunity

authors： Ierna MX,Scales HE,Mueller C,Lawrence CE

更新日期：2009-09-01 00:00:00

abstract：:A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). A severe reduction in peripheral blood neutrophils was induced 4 days after injection with ...

journal_title：Infection and immunity

authors： Matsumoto M,Matsubara S,Matsuno T,Tamura M,Hattori K,Nomura H,Ono M,Yokota T

更新日期：1987-11-01 00:00:00

abstract：:Di-, tri-, and tetrasaccharides, synthesized according to the chemical structure of pneumococcal polysaccharide type 3 (PS3), were coupled to the cross-reactive material (CRM(197)) of modified diphtheria toxin in different molar carbohydrate/protein ratios using the squarate coupling method. To study protective immuni...

journal_title：Infection and immunity

authors： Benaissa-Trouw B,Lefeber DJ,Kamerling JP,Vliegenthart JF,Kraaijeveld K,Snippe H

更新日期：2001-07-01 00:00:00

abstract：:T cell-independent antibody responses develop rapidly, within 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatening infections. The interaction of BAFF, also known as BLyS, with its receptors BAFFR and TACI on B cells is critical for B cell homeostasis and function. Usi...

journal_title：Infection and immunity

authors： Dickinson GS,Sun G,Bram RJ,Alugupalli KR

更新日期：2014-01-01 00:00:00

abstract：:Antisera were produced by inoculation of mycoplasma cells grown in PPLO broth supplemented with rabbit serum alone or rabbit serum plus Freund complete or incomplete adjuvant. By using an enzyme-linked immunosorbent assay, immunoglobulin G antibodies to cholesterol were detected in antisera to mycoplasmas (Mycoplasma ...

journal_title：Infection and immunity

authors： Watanabe T,Kumazawa T

更新日期：1991-06-01 00:00:00

abstract：:Serotype b-specific polysaccharide antigen (SPA) was extracted from whole cells of Actinobacillus actinomycetemcomitans Y4 by autoclaving and purified by chromatography on DEAE-Sephadex A-25 and Sephacryl S-300. SPA induced the release of monocyte and leukocyte chemotactic factors by human monocytes. Polymyxin B had a...

journal_title：Infection and immunity

authors： Yamaguchi N,Yamashita Y,Ikeda D,Koga T

更新日期：1996-07-01 00:00:00

abstract：:The mechanisms for acquisition of iron by Haemophilus influenzae and their role in pathogenesis are not known. Heme and nonheme sources of iron were evaluated for their effect on growth of type b and nontypable strains of H. influenzae in an iron-restricted, defined medium. All 13 strains acquired iron from heme, hemo...

journal_title：Infection and immunity

authors： Pidcock KA,Wooten JA,Daley BA,Stull TL

更新日期：1988-04-01 00:00:00

abstract：:Although nasal vaccination has emerged as an interesting alternative to systemic or oral vaccination, knowledge is scarce about the immune responses after such immunization in humans. In the present study, we have compared the kinetics and organ distribution of the antibody responses after nasal and oral vaccination. ...

journal_title：Infection and immunity

authors： Rudin A,Johansson EL,Bergquist C,Holmgren J

更新日期：1998-07-01 00:00:00

abstract：:Bacterial overgrowth in the small bowel is known to occur in patients with persistent diarrhea, but it has been unclear if colonization alone causes fluid secretion. We studied isogenic, nontoxigenic Escherichia coli strains with colonizing factor antigen II (CFA/II) (1392+) and without CFA/II (1392-) in 18-h rabbit i...

journal_title：Infection and immunity

authors： Wanke CA,Guerrant RL

更新日期：1987-08-01 00:00:00

abstract：:Porphyromonas gingivalis has been implicated as an etiologic agent of adult periodontitis. We have previously shown that P. gingivalis can degrade the epithelial cell-cell junction complexes, thus suggesting that this bacterium can invade the underlying connective tissues via a paracellular pathway. However, the preci...

journal_title：Infection and immunity

authors： Katz J,Yang QB,Zhang P,Potempa J,Travis J,Michalek SM,Balkovetz DF

更新日期：2002-05-01 00:00:00

abstract：:It is proposed that binding of oral streptococci to saliva-coated hydroxylapatite (SHA) surfaces is a multifactorial process involving both specific and nonspecific receptors. In this context, specific binding is described as a high-affinity, saturable interaction between the cell and binding surface. Conversely, nons...

journal_title：Infection and immunity

authors： Staat RH,Peyton JC

更新日期：1984-06-01 00:00:00

abstract：:Recent reports have suggested that oral vaccination of mice against Helicobacter pylori is dependent on a Th1-mediated immune response. However, oral vaccination in mice neither induces sterilizing immunity nor leads to complete protection from disease. Therefore, in this study we investigated whether a systemic subcu...

journal_title：Infection and immunity

authors： Sommer F,Wilken H,Faller G,Lohoff M

更新日期：2004-02-01 00:00:00

abstract：:Nasopharyngeal colonization represents the initial interaction between Haemophilus influenzae and its human host. Factors that influence bacterial carriage likely affect transmission and incidence of infection. Therefore, we investigated host factors involved in limiting H. influenzae colonization in BALB/c mice, as c...

journal_title：Infection and immunity

authors： Zola TA,Lysenko ES,Weiser JN

更新日期：2009-08-01 00:00:00

abstract：:The gram-negative bacterium nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic otitis media with effusion and, with Streptococcus pneumoniae and Moraxella catarrhalis, is a causative agent of acute otitis media. To identify potential virulence determinants, bacterial gene expression was m...

journal_title：Infection and immunity

authors： Mason KM,Munson RS Jr,Bakaletz LO

更新日期：2003-06-01 00:00:00

abstract：:Mycoplasma arthritidis causes acute polyarthritis in rats and chronic proliferative arthritis in mice. M. arthritidis-induced arthritis serves as a model for arthritis caused by infectious agents and as a model for examining the role of the superantigen MAM (M. arthritidis T-cell mitogen) in the development of autoimm...

journal_title：Infection and immunity

authors： Tu AH,Clapper B,Schoeb TR,Elgavish A,Zhang J,Liu L,Yu H,Dybvig K

更新日期：2005-01-01 00:00:00

abstract：:Two extremely oxygen-sensitive strains of Clostridium sp., designated Clostridium E and P, were obtained from digestive microflora of conventional mice and found to constitute a barrier against Shigella flexneri SF-2 when associated in vivo with Escherichia coli K-12. These and other simplified fractions of the conven...

journal_title：Infection and immunity

authors： Ducluzeau R,Ladire M,Callut C,Raibaud P,Abrams GD

更新日期：1977-08-01 00:00:00

abstract：:The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reac...

journal_title：Infection and immunity

authors： Brahimi K,Badell E,Sauzet JP,BenMohamed L,Daubersies P,Guérin-Marchand C,Snounou G,Druilhe P

更新日期：2001-06-01 00:00:00

abstract：:Trichomonas vaginalis is a sexually transmitted protozoan parasite that undergoes phenotypic variation for numerous surface proteins. A monoclonal antibody (MAb) was used to isolate an approximately 400-bp cDNA encoding a fragment of an important phenotypically varying immunogen of T. vaginalis (Mr = 270 kDa; P270). T...

journal_title：Infection and immunity

authors： Dailey DC,Alderete JF

更新日期：1991-06-01 00:00:00

abstract：:Production of group A streptococcal pyrogenic exotoxins (SPE) type A and C was transferred from toxigenic streptococcal strains to nontoxigenic strains by lysogeny. Lysogens were tested for SPE with Ouchterlony immunodiffusion on Todd-Hewitt agar plates; toxin diffusing from isolated colonies reacted with specific hyp...

journal_title：Infection and immunity

authors： Johnson LP,Schlievert PM,Watson DW

更新日期：1980-04-01 00:00:00

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:An immunosuppressed rat model of Pneumocystis carinii pneumonia is described that utilizes simple, noninvasive intratracheal (i.t.) inoculation of cryopreserved parasites and results in development of severe P. carinii pneumonia within 5 weeks. This is an improvement over the most commonly used models of P. carinii pn...

journal_title：Infection and immunity

authors： Boylan CJ,Current WL

更新日期：1992-04-01 00:00:00

abstract：:BCG vaccines are a family of closely related daughter strains of an attenuated isolate of Mycobacterium bovis derived by in vitro passage from 1908 to 1921. During subsequent laboratory propagation of the vaccine strain until its lyophilization in 1961, BCG Pasteur underwent at least seven further genomic mutations. T...

journal_title：Infection and immunity

authors： Belley A,Alexander D,Di Pietrantonio T,Girard M,Jones J,Schurr E,Liu J,Sherman DR,Behr MA

更新日期：2004-05-01 00:00:00

abstract：:The mechanisms by which Mycobacterium tuberculosis elicits disease are complex, involving a large repertoire of bacterial genes that are required for in vivo growth and survival. To identify such genes, we utilized a high-throughput microarray detection method to rapidly screen hundreds of unique, genotypically define...

journal_title：Infection and immunity

authors： Lamichhane G,Tyagi S,Bishai WR

更新日期：2005-04-01 00:00:00

abstract：:In pathogenic bacteria, iron acquisition is important for colonization and proliferation in the host under iron-limited conditions. The ability of Vibrio spp. to acquire iron is often critical to their virulence, causing gastroenteritis or excessive watery diarrhea in humans. In the study described here, we cloned the...

journal_title：Infection and immunity

authors： Ahn SH,Han JH,Lee JH,Park KJ,Kong IS

更新日期：2005-02-01 00:00:00

abstract：:Anti-rabbit alveolar macrophage goat serum (AMS), adsorbed of hemolysins and hemagglutinins, exhibited complement-dependent cytotoxicity for the following rabbit target cells: alveolar macrophages, thymocytes, and kidney (RK-13) cells. The intravenous injection of AMS, sufficient to reduce markedly the dermal tubercul...

journal_title：Infection and immunity

authors： Moore VL,Myrvik QN

更新日期：1970-12-01 00:00:00

abstract：:We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. Wu, J. T. Skare, D. B. Blanco, J. N. Miller, and M. A. Lovett, Infect. Immun. 68:4189-4199, 2000)...

journal_title：Infection and immunity

authors： Shang ES,Wu XY,Lovett MA,Miller JN,Blanco DR

更新日期：2001-01-01 00:00:00

abstract：:Outer membrane protein F (porin) was purified by extraction from polyacrylamide gels of cell envelope proteins of the Pseudomonas aeruginosa PAO1 strain. Rats were immunized intramuscularly with 25 micrograms of protein F on days 1 and 14 and then challenged on day 28 via intratracheal inoculation of bacterium-contain...

journal_title：Infection and immunity

authors： Gilleland HE Jr,Gilleland LB,Matthews-Greer JM

更新日期：1988-05-01 00:00:00

abstract：:The invasion of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocytes (PMNs) and the localization and distribution of tracers were followed during the process by electron microscopy. The seven tracers used were: cationized ferritin, ferritin, thorium dioxide (ThO2), carbon particles, l...

journal_title：Infection and immunity

authors： Rikihisa Y,Ito S

更新日期：1980-10-01 00:00:00